BGC0001433 - 1 region(s) - antiSMASH results

Identified secondary metabolite regions using strictness 'relaxed'

BGC0001433 (Streptomyces argillaceus)

Region	Type	From	To	Most similar known cluster		Similarity
Region 1	T1PKS	1	68,295	streptazone E	Polyketide	100%

BGC0001433 - Region 1 - T1PKS

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Location: 1 - 68,295 nt. (total: 68,295 nt) Show pHMM detection rules used

Region on contig edge.

T1PKS: cds(PKS_AT and (PKS_KS or ene_KS or mod_KS or hyb_KS or itr_KS or tra_KS))

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core biosynthetic genes

additional biosynthetic genes

transport-related genes

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TTA codons

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Gene details

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MIBiG

NRPS/PKS domains

MIBiG comparison

KnownClusterBlast

NRPS/PKS modules

External annotation

Name		MIBiG
Version		3.0

Type		Subregion
Location		1 - 68,296
Label		BGC0001433

Detailed domain annotation

Selected features only

Show module domains

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001433.1	0.93	Polyketide	argimycin PI, argimycin PII, nigrifactin, argimycin PIV, argimycin PV, argimycin PVI, argimycin PIX	Streptomyces argillaceus
BGC0001296.1	0.58	Polyketide	streptazone E	Streptomyces sp. MSC090213JE08
BGC0000068.1	0.36	Polyketide	geldanamycin	Streptomyces hygroscopicus
BGC0000041.1	0.35	Polyketide	oronofacic acid	Pseudomonas syringae
BGC0001273.1	0.29	Polyketide	asperlactone	Aspergillus ochraceus
BGC0001280.1	0.29	Polyketide	betaenone C, betaenone A	Phoma betae
BGC0001264.1	0.29	Polyketide	betaenone A, betaenone B, betaenone C	Phoma betae
BGC0001276.1	0.29	Polyketide	6-methylsalicyclic acid	Aspergillus terreus
BGC0001275.1	0.29	Polyketide	6-methylsalicyclic acid	Glarea lozoyensis
BGC0000067.1	0.29	Polyketide	geldanamycin	Streptomyces hygroscopicus subsp. duamyceticus

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001433.1	0.98	Polyketide	argimycin PI, argimycin PII, nigrifactin, argimycin PIV, argimycin PV, argimycin PVI, argimycin PIX	Streptomyces argillaceus
BGC0001296.1	0.83	Polyketide	streptazone E	Streptomyces sp. MSC090213JE08
BGC0000068.1	0.69	Polyketide	geldanamycin	Streptomyces hygroscopicus
BGC0000041.1	0.68	Polyketide	oronofacic acid	Pseudomonas syringae
BGC0001273.1	0.63	Polyketide	asperlactone	Aspergillus ochraceus
BGC0001280.1	0.62	Polyketide	betaenone C, betaenone A	Phoma betae
BGC0001264.1	0.62	Polyketide	betaenone A, betaenone B, betaenone C	Phoma betae
BGC0001276.1	0.62	Polyketide	6-methylsalicyclic acid	Aspergillus terreus
BGC0001275.1	0.62	Polyketide	6-methylsalicyclic acid	Glarea lozoyensis
BGC0000067.1	0.62	Polyketide	geldanamycin	Streptomyces hygroscopicus subsp. duamyceticus

Similar known gene clusters

Module view

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NRPS/PKS products

NRPS/PKS monomers

Predicted core structure(s)

For candidate cluster 1, location 0 - 67456:

Rough prediction of core scaffold based on assumed PKS linker matching; tailoring reactions not taken into account

Polymer prediction:: (mal - ccmal - ccmal) + (ccmal - ccmal) + (ccmal)
Non-colinear ordering:: arpPI + arpPII + arpPIII

Direct lookup in NORINE database: strict or relaxed

Link to NORINE database query form

NRPS/PKS monomer predictions

arpPI

PKS_AT (586..879): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 91.7%; inactive: 70.8%; Methylmalonyl-CoA: 58.3%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 202.3
inactive: 80.0
Methoxymalonyl-CoA: 66.6
Methylmalonyl-CoA: 62.6
Ethylmalonyl-CoA: 33.1
Isobutyryl-CoA: 31.8
Propionyl-CoA: 30.0
Acetyl-CoA: 25.3
2-Methylbutyryl-CoA: 20.9
Benzoyl-CoA: 13.5
trans-1,2-CPDA: 13.1
CHC-CoA: 10.3
fatty_acid: 0.0
3-Methylbutyryl-CoA: 0.0

PKS_AT (1612..1910): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 95.8%; inactive: 79.2%; Methylmalonyl-CoA: 58.3%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 205.4
inactive: 93.6
Methoxymalonyl-CoA: 73.1
Methylmalonyl-CoA: 66.6
Isobutyryl-CoA: 30.7
Propionyl-CoA: 29.6
Ethylmalonyl-CoA: 27.8
2-Methylbutyryl-CoA: 21.3
Acetyl-CoA: 17.9
fatty_acid: 14.5
Benzoyl-CoA: 9.6
trans-1,2-CPDA: 6.4
3-Methylbutyryl-CoA: 5.5
CHC-CoA: 2.9

PKS_AT (3376..3677): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 95.8%; inactive: 87.5%; 2-Rhyd-Malonyl-CoA: 54.2%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 207.8
inactive: 116.7
Methoxymalonyl-CoA: 65.9
Methylmalonyl-CoA: 57.6
Propionyl-CoA: 35.0
2-Methylbutyryl-CoA: 27.5
Isobutyryl-CoA: 24.2
Ethylmalonyl-CoA: 21.5
Benzoyl-CoA: 17.7
CHC-CoA: 14.5
Acetyl-CoA: 13.4
fatty_acid: 12.6
trans-1,2-CPDA: 0.0
3-Methylbutyryl-CoA: 0.0

arpPII

PKS_AT (592..883): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 95.8%; inactive: 70.8%; Methylmalonyl-CoA: 58.3%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 193.3
inactive: 74.7
Methoxymalonyl-CoA: 71.7
Methylmalonyl-CoA: 69.4
Propionyl-CoA: 49.5
Isobutyryl-CoA: 39.1
Ethylmalonyl-CoA: 33.0
2-Methylbutyryl-CoA: 25.1
Acetyl-CoA: 21.7
Benzoyl-CoA: 19.0
fatty_acid: 17.8
CHC-CoA: 17.7
trans-1,2-CPDA: 10.8
3-Methylbutyryl-CoA: 0.0

PKS_AT (2291..2583): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 95.8%; inactive: 70.8%; Methylmalonyl-CoA: 58.3%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 191.4
inactive: 73.3
Methylmalonyl-CoA: 72.1
Methoxymalonyl-CoA: 70.0
Propionyl-CoA: 40.0
Isobutyryl-CoA: 35.7
Ethylmalonyl-CoA: 30.5
Acetyl-CoA: 23.6
CHC-CoA: 19.9
2-Methylbutyryl-CoA: 19.6
Benzoyl-CoA: 18.6
fatty_acid: 14.5
trans-1,2-CPDA: 8.3
3-Methylbutyryl-CoA: 8.0

arpPIII

PKS_AT (579..871): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 95.8%; inactive: 70.8%; Methylmalonyl-CoA: 58.3%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 191.9
inactive: 69.9
Methoxymalonyl-CoA: 69.5
Methylmalonyl-CoA: 69.2
Propionyl-CoA: 43.4
Isobutyryl-CoA: 34.4
Ethylmalonyl-CoA: 28.1
Acetyl-CoA: 23.8
2-Methylbutyryl-CoA: 22.1
CHC-CoA: 19.5
Benzoyl-CoA: 18.6
fatty_acid: 13.7
trans-1,2-CPDA: 8.1
3-Methylbutyryl-CoA: 0.0

orf11

CAL_domain (152..468): pk

minowa: NH2

Prediction, score:

NH2: 69.4
fatty_acid: 27.8
Acetyl-CoA: 19.6
shikimic_acid: 0.0
AHBA: 0.0