BGC0001755 - 1 region(s) - antiSMASH results

Identified secondary metabolite regions using strictness 'relaxed'

BGC0001755 (Streptomyces sp)

Region	Type	From	To	Most similar known cluster		Similarity
Region 1	T1PKS	1	103,914	lydicamycin	NRP + Polyketide:Modular type I	20%

BGC0001755 - Region 1 - T1PKS

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Location: 1 - 103,914 nt. (total: 103,914 nt) Show pHMM detection rules used

Region on contig edge.

T1PKS: cds(PKS_AT and (PKS_KS or ene_KS or mod_KS or hyb_KS or itr_KS or tra_KS))

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core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

TTA codons

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Gene details

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MIBiG

NRPS/PKS domains

MIBiG comparison

KnownClusterBlast

NRPS/PKS modules

External annotation

Name		MIBiG
Version		3.0

Type		Subregion
Location		1 - 103,915
Label		BGC0001755

Detailed domain annotation

Selected features only

Show module domains

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001755.1	0.84	Polyketide	reedsmycins	Streptomyces sp.
BGC0000067.1	0.31	Polyketide	geldanamycin	Streptomyces hygroscopicus subsp. duamyceticus
BGC0001275.1	0.29	Polyketide	6-methylsalicyclic acid	Glarea lozoyensis
BGC0001244.1	0.29	Polyketide	(-)-Mellein	Parastagonospora nodorum
BGC0001164.1	0.28	Polyketide	1-heptadecene	Cyanothece sp. PCC 7822
BGC0001012.1	0.27	NRP, Polyketide	meridamycin	Streptomyces violaceusniger
BGC0000122.1	0.26	Polyketide	phenylnannolone A, phenylnannolone B, phenylnannolone C	Nannocystis pusilla
BGC0000353.1	0.25	NRP	tacrolimus	Streptomyces sp. MA6548
BGC0001162.1	0.24	Polyketide	1-heptadecene	Moorea producens JHB
BGC0001235.1	0.23	NRP, Polyketide	antalid	Polyangium spumosum

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001755.1	0.94	Polyketide	reedsmycins	Streptomyces sp.
BGC0000067.1	0.65	Polyketide	geldanamycin	Streptomyces hygroscopicus subsp. duamyceticus
BGC0001275.1	0.63	Polyketide	6-methylsalicyclic acid	Glarea lozoyensis
BGC0001244.1	0.62	Polyketide	(-)-Mellein	Parastagonospora nodorum
BGC0001164.1	0.62	Polyketide	1-heptadecene	Cyanothece sp. PCC 7822
BGC0001012.1	0.61	NRP, Polyketide	meridamycin	Streptomyces violaceusniger
BGC0000122.1	0.60	Polyketide	phenylnannolone A, phenylnannolone B, phenylnannolone C	Nannocystis pusilla
BGC0000353.1	0.58	NRP	tacrolimus	Streptomyces sp. MA6548
BGC0001162.1	0.57	Polyketide	1-heptadecene	Moorea producens JHB
BGC0001235.1	0.57	NRP, Polyketide	antalid	Polyangium spumosum

Similar known gene clusters

Module view

Legend

NRPS/PKS products

NRPS/PKS monomers

Predicted core structure(s)

For candidate cluster 1, location 0 - 103914:

Rough prediction of core scaffold based on assumed PKS linker matching; tailoring reactions not taken into account

Polymer prediction:: (pk - Me-redmal - Me-ccmal) + (ccmal - ohmal - ohmal - ohmal) + (ohmal - ohmal - ohmal - ohmal - ohmal - ccmal) + (ccmal - ccmal - ccmal - ccmal)
Non-colinear ordering:: rdmG + rdmH + rdmI + rdmJ

Direct lookup in NORINE database: strict or relaxed

Link to NORINE database query form

NRPS/PKS monomer predictions

rdmG

PKS_AT (551..848): pk

ATSignature: Methylmalonyl-CoA, Methoxymalonyl-CoA

Top 3 matches:: Methylmalonyl-CoA: 91.7%; Methoxymalonyl-CoA: 91.7%; Ethylmalonyl-CoA: 87.5%

minowa: Ethylmalonyl-CoA

Prediction, score:

Ethylmalonyl-CoA: 191.3
Methylmalonyl-CoA: 181.9
Methoxymalonyl-CoA: 162.4
trans-1,2-CPDA: 135.4
2-Methylbutyryl-CoA: 123.1
Propionyl-CoA: 103.2
CHC-CoA: 97.5
Malonyl-CoA: 93.9
Isobutyryl-CoA: 76.7
Benzoyl-CoA: 57.9
Acetyl-CoA: 47.8
fatty_acid: 39.8
inactive: 25.3
3-Methylbutyryl-CoA: 20.7

PKS_AT (1570..1867): mmal

ATSignature: Methylmalonyl-CoA

Top 3 matches:: Methylmalonyl-CoA: 95.8%; Methoxymalonyl-CoA: 87.5%; Ethylmalonyl-CoA: 83.3%

minowa: Methylmalonyl-CoA

Prediction, score:

Methylmalonyl-CoA: 193.4
Ethylmalonyl-CoA: 163.5
Methoxymalonyl-CoA: 158.5
2-Methylbutyryl-CoA: 129.6
CHC-CoA: 119.5
Propionyl-CoA: 108.0
trans-1,2-CPDA: 105.4
Malonyl-CoA: 85.6
Isobutyryl-CoA: 63.7
Benzoyl-CoA: 49.9
Acetyl-CoA: 40.9
3-Methylbutyryl-CoA: 39.8
fatty_acid: 37.6
inactive: 21.5

PKS_AT (3686..3983): mmal

ATSignature: Methylmalonyl-CoA

Top 3 matches:: Methylmalonyl-CoA: 100.0%; Methoxymalonyl-CoA: 91.7%; Ethylmalonyl-CoA: 87.5%

minowa: Methylmalonyl-CoA

Prediction, score:

Methylmalonyl-CoA: 200.5
Ethylmalonyl-CoA: 186.4
Methoxymalonyl-CoA: 163.4
2-Methylbutyryl-CoA: 144.3
trans-1,2-CPDA: 131.6
Propionyl-CoA: 117.8
Malonyl-CoA: 103.3
CHC-CoA: 97.2
Isobutyryl-CoA: 66.2
Benzoyl-CoA: 62.7
Acetyl-CoA: 60.0
fatty_acid: 46.9
3-Methylbutyryl-CoA: 42.5
inactive: 29.8

rdmH

PKS_AT (572..853): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 91.7%; inactive: 75.0%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 206.7
inactive: 86.7
Methoxymalonyl-CoA: 51.2
Methylmalonyl-CoA: 45.6
Propionyl-CoA: 31.3
Acetyl-CoA: 24.2
Isobutyryl-CoA: 19.8
Benzoyl-CoA: 14.3
fatty_acid: 11.2
CHC-CoA: 7.7
Ethylmalonyl-CoA: 2.9
trans-1,2-CPDA: 0.0
3-Methylbutyryl-CoA: 0.0
2-Methylbutyryl-CoA: 0.0

PKS_AT (2287..2574): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 91.7%; inactive: 75.0%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 210.6
inactive: 91.5
Methoxymalonyl-CoA: 55.0
Methylmalonyl-CoA: 51.2
Acetyl-CoA: 27.9
Isobutyryl-CoA: 26.5
Propionyl-CoA: 24.7
fatty_acid: 15.6
Ethylmalonyl-CoA: 14.4
Benzoyl-CoA: 12.1
CHC-CoA: 7.1
2-Methylbutyryl-CoA: 4.8
trans-1,2-CPDA: 0.0
3-Methylbutyryl-CoA: 0.0

PKS_AT (3831..4118): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 91.7%; inactive: 75.0%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 206.4
inactive: 102.7
Methoxymalonyl-CoA: 52.1
Methylmalonyl-CoA: 47.1
Propionyl-CoA: 25.0
Isobutyryl-CoA: 24.4
Acetyl-CoA: 19.7
fatty_acid: 13.1
Benzoyl-CoA: 11.7
CHC-CoA: 9.0
trans-1,2-CPDA: 0.0
Ethylmalonyl-CoA: 0.0
3-Methylbutyryl-CoA: 0.0
2-Methylbutyryl-CoA: 0.0

PKS_AT (5370..5657): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 91.7%; inactive: 75.0%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 208.5
inactive: 94.9
Methoxymalonyl-CoA: 52.1
Methylmalonyl-CoA: 44.9
Isobutyryl-CoA: 28.7
Acetyl-CoA: 24.7
Propionyl-CoA: 21.5
fatty_acid: 11.1
Ethylmalonyl-CoA: 9.4
Benzoyl-CoA: 8.2
CHC-CoA: 5.9
trans-1,2-CPDA: 0.0
3-Methylbutyryl-CoA: 0.0
2-Methylbutyryl-CoA: 0.0

rdmI

PKS_AT (569..849): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 91.7%; inactive: 75.0%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 214.5
inactive: 95.4
Methoxymalonyl-CoA: 53.5
Methylmalonyl-CoA: 49.8
Isobutyryl-CoA: 37.3
Acetyl-CoA: 27.9
Propionyl-CoA: 23.7
fatty_acid: 12.3
Benzoyl-CoA: 11.1
CHC-CoA: 8.0
Ethylmalonyl-CoA: 7.4
trans-1,2-CPDA: 0.0
3-Methylbutyryl-CoA: 0.0
2-Methylbutyryl-CoA: 0.0

PKS_AT (2093..2373): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 91.7%; inactive: 75.0%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 213.5
inactive: 94.7
Methoxymalonyl-CoA: 54.4
Methylmalonyl-CoA: 48.1
Isobutyryl-CoA: 29.4
Propionyl-CoA: 27.6
Acetyl-CoA: 22.2
Benzoyl-CoA: 12.3
fatty_acid: 11.5
2-Methylbutyryl-CoA: 8.9
Ethylmalonyl-CoA: 5.1
trans-1,2-CPDA: 0.0
CHC-CoA: 0.0
3-Methylbutyryl-CoA: 0.0

PKS_AT (3633..3920): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 91.7%; inactive: 75.0%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 212.6
inactive: 93.0
Methoxymalonyl-CoA: 52.4
Methylmalonyl-CoA: 48.2
Isobutyryl-CoA: 33.0
Propionyl-CoA: 26.1
Acetyl-CoA: 24.4
fatty_acid: 12.9
Benzoyl-CoA: 10.9
Ethylmalonyl-CoA: 9.9
2-Methylbutyryl-CoA: 7.6
CHC-CoA: 5.8
trans-1,2-CPDA: 0.0
3-Methylbutyryl-CoA: 0.0

PKS_AT (5167..5454): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 91.7%; inactive: 75.0%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 215.7
inactive: 100.6
Methoxymalonyl-CoA: 57.2
Methylmalonyl-CoA: 49.8
Isobutyryl-CoA: 28.8
Acetyl-CoA: 27.0
Propionyl-CoA: 25.8
2-Methylbutyryl-CoA: 14.0
Benzoyl-CoA: 12.4
Ethylmalonyl-CoA: 8.9
fatty_acid: 8.3
CHC-CoA: 7.8
trans-1,2-CPDA: 0.0
3-Methylbutyryl-CoA: 0.0

PKS_AT (6701..6988): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 91.7%; inactive: 75.0%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 204.5
inactive: 102.5
Methoxymalonyl-CoA: 47.6
Methylmalonyl-CoA: 41.2
Isobutyryl-CoA: 34.3
Propionyl-CoA: 19.2
Acetyl-CoA: 19.0
fatty_acid: 12.9
Benzoyl-CoA: 11.3
2-Methylbutyryl-CoA: 10.2
CHC-CoA: 8.0
Ethylmalonyl-CoA: 5.5
trans-1,2-CPDA: 0.0
3-Methylbutyryl-CoA: 0.0

PKS_AT (8228..8515): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 91.7%; inactive: 75.0%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 207.3
inactive: 106.6
Methoxymalonyl-CoA: 50.1
Methylmalonyl-CoA: 42.9
Isobutyryl-CoA: 32.9
Propionyl-CoA: 19.8
Acetyl-CoA: 17.3
fatty_acid: 15.0
Benzoyl-CoA: 12.9
CHC-CoA: 7.2
2-Methylbutyryl-CoA: 5.3
Ethylmalonyl-CoA: 4.3
trans-1,2-CPDA: 0.0
3-Methylbutyryl-CoA: 0.0

rdmJ

PKS_AT (588..870): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 91.7%; inactive: 75.0%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 214.4
inactive: 90.6
Methoxymalonyl-CoA: 56.0
Methylmalonyl-CoA: 50.1
Isobutyryl-CoA: 34.4
Propionyl-CoA: 30.8
Acetyl-CoA: 28.2
fatty_acid: 14.0
Ethylmalonyl-CoA: 13.5
Benzoyl-CoA: 11.0
CHC-CoA: 5.3
trans-1,2-CPDA: 0.0
3-Methylbutyryl-CoA: 0.0
2-Methylbutyryl-CoA: 0.0

PKS_AT (2308..2588): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 91.7%; inactive: 79.2%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 207.2
inactive: 93.2
Methoxymalonyl-CoA: 52.8
Methylmalonyl-CoA: 45.6
Isobutyryl-CoA: 32.3
Propionyl-CoA: 26.5
Acetyl-CoA: 25.8
Benzoyl-CoA: 11.8
fatty_acid: 11.7
Ethylmalonyl-CoA: 5.8
trans-1,2-CPDA: 0.0
CHC-CoA: 0.0
3-Methylbutyryl-CoA: 0.0
2-Methylbutyryl-CoA: 0.0

PKS_AT (4030..4311): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 91.7%; inactive: 79.2%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 207.1
inactive: 99.1
Methoxymalonyl-CoA: 51.7
Methylmalonyl-CoA: 43.6
Isobutyryl-CoA: 30.6
Acetyl-CoA: 25.7
Propionyl-CoA: 24.8
Benzoyl-CoA: 11.4
fatty_acid: 8.9
2-Methylbutyryl-CoA: 4.9
CHC-CoA: 4.0
Ethylmalonyl-CoA: 3.2
trans-1,2-CPDA: 0.0
3-Methylbutyryl-CoA: 0.0

PKS_AT (5746..6030): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 91.7%; inactive: 79.2%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 216.0
inactive: 100.4
Methoxymalonyl-CoA: 56.4
Methylmalonyl-CoA: 45.5
Isobutyryl-CoA: 26.7
Propionyl-CoA: 25.1
Acetyl-CoA: 20.2
Benzoyl-CoA: 12.3
fatty_acid: 11.7
2-Methylbutyryl-CoA: 10.4
CHC-CoA: 8.4
Ethylmalonyl-CoA: 5.3
trans-1,2-CPDA: 0.0
3-Methylbutyryl-CoA: 0.0

rdmN

Search NORINE for peptide: strict or relaxed

AMP-binding (26..468): X

NRPSPredictor2: (unknown)

SVM prediction details:

NOTE: outside applicability domain

Predicted physicochemical class:: hydrophobic-aliphatic
Large clusters prediction:: N/A
Small clusters prediction:: N/A
Single AA prediction:: N/A

Stachelhaus prediction details:

Stachelhaus sequence:: DmgALGvlAK
Nearest Stachelhaus code:: leu
Stachelhaus code match:: 60% (weak)