BGC0000003 - 1 region(s) - antiSMASH results

Identified secondary metabolite regions using strictness 'relaxed'

BGC0000003 (Alternaria alternata)

Region	Type	From	To	Most similar known cluster		Similarity
Region 1	T1PKS	1	37,168	AK-toxin I	Polyketide	33%

BGC0000003 - Region 1 - T1PKS

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Location: 1 - 37,168 nt. (total: 37,168 nt) Show pHMM detection rules used

Region on contig edge.

T1PKS: cds(PKS_AT and (PKS_KS or ene_KS or mod_KS or hyb_KS or itr_KS or tra_KS))

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core biosynthetic genes

additional biosynthetic genes

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Gene details

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MIBiG

NRPS/PKS domains

MIBiG comparison

KnownClusterBlast

NRPS/PKS modules

External annotation

Name		MIBiG
Version		3.0

Type		Subregion
Location		1 - 37,169
Label		BGC0000003

Detailed domain annotation

Selected features only

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Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000003.1	1.00	Polyketide	AF-toxin	Alternaria alternata
BGC0001068.1	0.28	Terpene, Polyketide	pyripyropene A	unidentified unclassified sequences.
BGC0001280.1	0.24	Polyketide	betaenone C, betaenone A	Phoma betae
BGC0001264.1	0.24	Polyketide	betaenone A, betaenone B, betaenone C	Phoma betae
BGC0000046.1	0.23	Polyketide	depudecin	Alternaria brassicicola
BGC0001262.1	0.20	Polyketide	AK-toxin I	Alternaria alternata
BGC0001124.1	0.19	Polyketide	pyranonigrin E	Aspergillus niger ATCC 1015
BGC0001141.1	0.19	Polyketide	4-epi-15-epi-brefeldin A	Penicillium brefeldianum
BGC0001252.1	0.18	Polyketide	UNII-YC2Q1O94PT	Alternaria alternata
BGC0001858.1	0.18	Polyketide	alternapyrone B, alternapyrone C, alternapyrone D, alternapyrone E, alternapyrone F	Parastagonospora nodorum SN15

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000003.1	1.00	Polyketide	AF-toxin	Alternaria alternata
BGC0001068.1	0.62	Terpene, Polyketide	pyripyropene A	unidentified unclassified sequences.
BGC0001280.1	0.58	Polyketide	betaenone C, betaenone A	Phoma betae
BGC0001264.1	0.58	Polyketide	betaenone A, betaenone B, betaenone C	Phoma betae
BGC0000046.1	0.56	Polyketide	depudecin	Alternaria brassicicola
BGC0001262.1	0.53	Polyketide	AK-toxin I	Alternaria alternata
BGC0001124.1	0.52	Polyketide	pyranonigrin E	Aspergillus niger ATCC 1015
BGC0001141.1	0.51	Polyketide	4-epi-15-epi-brefeldin A	Penicillium brefeldianum
BGC0001252.1	0.50	Polyketide	UNII-YC2Q1O94PT	Alternaria alternata
BGC0001858.1	0.50	Polyketide	alternapyrone B, alternapyrone C, alternapyrone D, alternapyrone E, alternapyrone F	Parastagonospora nodorum SN15

Similar known gene clusters

Module view

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NRPS/PKS products

NRPS/PKS monomers

Predicted core structure(s)

For candidate cluster 1, location 0 - 37168:

Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:: (Me-pk)

Direct lookup in NORINE database: strict or relaxed

Link to NORINE database query form

NRPS/PKS monomer predictions

AFT9-1

PKS_AT (436..750): pk

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 83.3%; Methylmalonyl-CoA: 62.5%; Ethylmalonyl-CoA: 58.3%

minowa: Methylmalonyl-CoA

Prediction, score:

Methylmalonyl-CoA: 92.1
Methoxymalonyl-CoA: 85.0
Isobutyryl-CoA: 54.1
Malonyl-CoA: 49.4
Ethylmalonyl-CoA: 49.3
Benzoyl-CoA: 26.8
Acetyl-CoA: 25.5
trans-1,2-CPDA: 21.5
2-Methylbutyryl-CoA: 18.7
fatty_acid: 18.3
CHC-CoA: 17.5
3-Methylbutyryl-CoA: 17.0
Propionyl-CoA: 11.7
inactive: 0.0