BGC0000018 - 1 region(s) - antiSMASH results

Identified secondary metabolite regions using strictness 'relaxed'

BGC0000018 (Streptomyces eurythermus)

Region	Type	From	To	Most similar known cluster		Similarity
Region 1	T1PKS	1	42,960	chalcomycin A	Polyketide	12%

BGC0000018 - Region 1 - T1PKS

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Location: 1 - 42,960 nt. (total: 42,960 nt) Show pHMM detection rules used

Region on contig edge.

T1PKS: cds(PKS_AT and (PKS_KS or ene_KS or mod_KS or hyb_KS or itr_KS or tra_KS))

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core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

TTA codons

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Gene details

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MIBiG

NRPS/PKS domains

MIBiG comparison

KnownClusterBlast

NRPS/PKS modules

External annotation

Name		MIBiG
Version		3.0

Type		Subregion
Location		1 - 42,961
Label		BGC0000018

Detailed domain annotation

Selected features only

Show module domains

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000018.1	0.75	Polyketide	angolamycin	Streptomyces eurythermus
BGC0000113.1	0.37	Polyketide	niddamycin	Streptomyces caelestis
BGC0000041.1	0.36	Polyketide	oronofacic acid	Pseudomonas syringae
BGC0002086.1	0.32	Polyketide	rosamicin	Micromonospora carbonacea
BGC0001812.1	0.28	Polyketide	tylactone	Micromonospora chalcea subsp. izumensis
BGC0001164.1	0.28	Polyketide	1-heptadecene	Cyanothece sp. PCC 7822
BGC0000067.1	0.27	Polyketide	geldanamycin	Streptomyces hygroscopicus subsp. duamyceticus
BGC0000080.1	0.26	Polyketide	jerangolid A, jerangolid D	Sorangium cellulosum
BGC0000072.1	0.25	Polyketide	gulmirecin A	Pyxidicoccus fallax
BGC0001653.1	0.25	Polyketide	linfuranone B, linfuranone C	Microbispora sp. GMKU363

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000018.1	0.91	Polyketide	angolamycin	Streptomyces eurythermus
BGC0000113.1	0.70	Polyketide	niddamycin	Streptomyces caelestis
BGC0000041.1	0.69	Polyketide	oronofacic acid	Pseudomonas syringae
BGC0002086.1	0.66	Polyketide	rosamicin	Micromonospora carbonacea
BGC0001812.1	0.62	Polyketide	tylactone	Micromonospora chalcea subsp. izumensis
BGC0001164.1	0.62	Polyketide	1-heptadecene	Cyanothece sp. PCC 7822
BGC0000067.1	0.61	Polyketide	geldanamycin	Streptomyces hygroscopicus subsp. duamyceticus
BGC0000080.1	0.60	Polyketide	jerangolid A, jerangolid D	Sorangium cellulosum
BGC0000072.1	0.59	Polyketide	gulmirecin A	Pyxidicoccus fallax
BGC0001653.1	0.58	Polyketide	linfuranone B, linfuranone C	Microbispora sp. GMKU363

Similar known gene clusters

Module view

Legend

NRPS/PKS products

NRPS/PKS monomers

Predicted core structure(s)

For candidate cluster 1, location 0 - 42960:

Rough prediction of core scaffold based on assumed PKS linker matching; tailoring reactions not taken into account

Polymer prediction:: (Me-mal - Me-ohmal - Me-ccmal) + (ccmal) + (Me-ccmal) + (Me-ohmal - redemal) + (ohmal)
Non-colinear ordering:: angAI + angAII + angAIV + angAIII + angAV

Direct lookup in NORINE database: strict or relaxed

Link to NORINE database query form

NRPS/PKS monomer predictions

angAI

PKS_AT (595..889): mmal

ATSignature: Methylmalonyl-CoA

Top 3 matches:: Methylmalonyl-CoA: 100.0%; Methoxymalonyl-CoA: 95.8%; Ethylmalonyl-CoA: 91.7%

minowa: Methylmalonyl-CoA

Prediction, score:

Methylmalonyl-CoA: 222.8
Ethylmalonyl-CoA: 215.6
Methoxymalonyl-CoA: 179.0
2-Methylbutyryl-CoA: 143.1
trans-1,2-CPDA: 126.9
Propionyl-CoA: 106.9
CHC-CoA: 97.5
Malonyl-CoA: 89.5
Isobutyryl-CoA: 85.5
Benzoyl-CoA: 81.0
Acetyl-CoA: 43.3
fatty_acid: 30.8
3-Methylbutyryl-CoA: 30.5
inactive: 25.8

PKS_AT (1594..1888): mmal

ATSignature: Methylmalonyl-CoA

Top 3 matches:: Methylmalonyl-CoA: 100.0%; Methoxymalonyl-CoA: 95.8%; Ethylmalonyl-CoA: 91.7%

minowa: Methylmalonyl-CoA

Prediction, score:

Methylmalonyl-CoA: 221.1
Ethylmalonyl-CoA: 217.9
Methoxymalonyl-CoA: 177.9
2-Methylbutyryl-CoA: 141.3
trans-1,2-CPDA: 125.9
Propionyl-CoA: 106.9
CHC-CoA: 99.5
Malonyl-CoA: 88.8
Isobutyryl-CoA: 81.0
Benzoyl-CoA: 80.4
Acetyl-CoA: 44.2
fatty_acid: 32.2
3-Methylbutyryl-CoA: 29.2
inactive: 25.5

PKS_AT (3078..3340): mmal

ATSignature: Ethylmalonyl-CoA, Methylmalonyl-CoA, Methoxymalonyl-CoA

Top 3 matches:: Ethylmalonyl-CoA: 79.2%; Methylmalonyl-CoA: 79.2%; Methoxymalonyl-CoA: 79.2%

minowa: Methylmalonyl-CoA

Prediction, score:

Methylmalonyl-CoA: 172.4
Methoxymalonyl-CoA: 150.0
Ethylmalonyl-CoA: 134.4
2-Methylbutyryl-CoA: 112.5
trans-1,2-CPDA: 104.6
Propionyl-CoA: 83.6
CHC-CoA: 82.0
Malonyl-CoA: 64.2
Benzoyl-CoA: 51.9
Isobutyryl-CoA: 44.7
Acetyl-CoA: 19.1
inactive: 17.9
fatty_acid: 16.3
3-Methylbutyryl-CoA: 14.1

angAII

PKS_AT (641..983): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 95.8%; inactive: 87.5%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 219.5
inactive: 120.8
Methoxymalonyl-CoA: 80.4
Methylmalonyl-CoA: 70.4
Isobutyryl-CoA: 42.3
Ethylmalonyl-CoA: 30.7
Propionyl-CoA: 28.1
Acetyl-CoA: 24.8
Benzoyl-CoA: 19.2
CHC-CoA: 18.6
2-Methylbutyryl-CoA: 17.5
fatty_acid: 13.3
3-Methylbutyryl-CoA: 10.9
trans-1,2-CPDA: 10.6

angAIII

PKS_AT (569..863): mmal

ATSignature: Methylmalonyl-CoA

Top 3 matches:: Methylmalonyl-CoA: 100.0%; Methoxymalonyl-CoA: 95.8%; Ethylmalonyl-CoA: 91.7%

minowa: Methylmalonyl-CoA

Prediction, score:

Methylmalonyl-CoA: 222.9
Ethylmalonyl-CoA: 214.6
Methoxymalonyl-CoA: 179.8
2-Methylbutyryl-CoA: 149.1
trans-1,2-CPDA: 126.5
Propionyl-CoA: 108.0
CHC-CoA: 95.2
Malonyl-CoA: 89.9
Isobutyryl-CoA: 87.5
Benzoyl-CoA: 78.4
Acetyl-CoA: 44.3
fatty_acid: 33.3
3-Methylbutyryl-CoA: 31.0
inactive: 29.0

PKS_AT (2148..2445): emal

ATSignature: Ethylmalonyl-CoA

Top 3 matches:: Ethylmalonyl-CoA: 100.0%; Methoxymalonyl-CoA: 91.7%; Methylmalonyl-CoA: 91.7%

minowa: Ethylmalonyl-CoA

Prediction, score:

Ethylmalonyl-CoA: 234.6
Methylmalonyl-CoA: 207.6
Methoxymalonyl-CoA: 182.0
trans-1,2-CPDA: 159.6
2-Methylbutyryl-CoA: 148.7
Propionyl-CoA: 118.4
CHC-CoA: 107.5
Malonyl-CoA: 83.9
Isobutyryl-CoA: 71.9
Benzoyl-CoA: 61.6
Acetyl-CoA: 56.1
fatty_acid: 46.5
3-Methylbutyryl-CoA: 36.2
inactive: 17.4

angAIV

PKS_AT (557..851): mmal

ATSignature: Methylmalonyl-CoA

Top 3 matches:: Methylmalonyl-CoA: 100.0%; Methoxymalonyl-CoA: 95.8%; Ethylmalonyl-CoA: 91.7%

minowa: Methylmalonyl-CoA

Prediction, score:

Methylmalonyl-CoA: 222.3
Ethylmalonyl-CoA: 214.0
Methoxymalonyl-CoA: 176.0
2-Methylbutyryl-CoA: 140.7
trans-1,2-CPDA: 121.9
Propionyl-CoA: 103.4
CHC-CoA: 94.7
Malonyl-CoA: 88.3
Benzoyl-CoA: 76.9
Isobutyryl-CoA: 73.9
Acetyl-CoA: 42.7
fatty_acid: 33.5
3-Methylbutyryl-CoA: 23.6
inactive: 21.2

angAV

PKS_AT (599..899): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 91.7%; inactive: 79.2%; Methylmalonyl-CoA: 54.2%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 204.4
inactive: 94.0
Methoxymalonyl-CoA: 59.5
Methylmalonyl-CoA: 51.3
Propionyl-CoA: 34.8
Acetyl-CoA: 25.4
Ethylmalonyl-CoA: 19.1
CHC-CoA: 16.7
Isobutyryl-CoA: 14.9
Benzoyl-CoA: 14.0
2-Methylbutyryl-CoA: 12.6
fatty_acid: 10.7
trans-1,2-CPDA: 0.0
3-Methylbutyryl-CoA: 0.0