BGC0000051 - 1 region(s) - antiSMASH results

Identified secondary metabolite regions using strictness 'relaxed'

BGC0000051 (Kitasatospora aburaviensis)

Region	Type	From	To	Most similar known cluster		Similarity
Region 1	T1PKS	1	37,060	ebelactone	Polyketide	22%

BGC0000051 - Region 1 - T1PKS

Download region GenBank file

Download region SVG

Location: 1 - 37,060 nt. (total: 37,060 nt) Show pHMM detection rules used

Region on contig edge.

T1PKS: cds(PKS_AT and (PKS_KS or ene_KS or mod_KS or hyb_KS or itr_KS or tra_KS))

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

TTA codons

reset view

zoom to selection

Gene details

Select a gene to view the details available for it

MIBiG

NRPS/PKS domains

MIBiG comparison

KnownClusterBlast

NRPS/PKS modules

External annotation

Name		MIBiG
Version		3.0

Type		Subregion
Location		1 - 37,061
Label		BGC0000051

Detailed domain annotation

Selected features only

Show module domains

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000051.1	0.73	Polyketide	ebelactone A, ebelactone B	Kitasatospora aburaviensis
BGC0001580.1	0.36	Polyketide	ebelactone	Kitasatospora aburaviensis
BGC0000041.1	0.30	Polyketide	oronofacic acid	Pseudomonas syringae
BGC0001258.1	0.29	Polyketide	1,3,6,8-tetrahydroxynaphthalene	Glarea lozoyensis
BGC0000107.1	0.29	Polyketide	naphthopyrone	Aspergillus nidulans FGSC A4
BGC0000156.1	0.29	Polyketide	TAN-1612, 1-(2,3,5,10-tetrahydroxy-7-methoxy-4-oxo-1,2,3,4-tetrahydroanthracen-2-yl)pentane-2,4-dione, desmethyl TAN-1612	Aspergillus niger
BGC0000057.1	0.29	Polyketide	F9775A, F9775B, orsellinic acid	Aspergillus nidulans FGSC A4
BGC0001906.1	0.29	Polyketide	naphthalene	Daldinia eschscholzii IFB-TL01
BGC0001284.1	0.29	Terpene	alternariol	Parastagonospora nodorum SN15
BGC0001257.1	0.29	Polyketide	1,3,6,8-tetrahydroxynaphthalene	Nodulisporium sp. ATCC74245

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000051.1	0.90	Polyketide	ebelactone A, ebelactone B	Kitasatospora aburaviensis
BGC0001580.1	0.69	Polyketide	ebelactone	Kitasatospora aburaviensis
BGC0000041.1	0.63	Polyketide	oronofacic acid	Pseudomonas syringae
BGC0001258.1	0.63	Polyketide	1,3,6,8-tetrahydroxynaphthalene	Glarea lozoyensis
BGC0000107.1	0.63	Polyketide	naphthopyrone	Aspergillus nidulans FGSC A4
BGC0000156.1	0.62	Polyketide	TAN-1612, 1-(2,3,5,10-tetrahydroxy-7-methoxy-4-oxo-1,2,3,4-tetrahydroanthracen-2-yl)pentane-2,4-dione, desmethyl TAN-1612	Aspergillus niger
BGC0000057.1	0.62	Polyketide	F9775A, F9775B, orsellinic acid	Aspergillus nidulans FGSC A4
BGC0001906.1	0.62	Polyketide	naphthalene	Daldinia eschscholzii IFB-TL01
BGC0001284.1	0.62	Terpene	alternariol	Parastagonospora nodorum SN15
BGC0001257.1	0.62	Polyketide	1,3,6,8-tetrahydroxynaphthalene	Nodulisporium sp. ATCC74245

Similar known gene clusters

Module view

Legend

NRPS/PKS products

NRPS/PKS monomers

Predicted core structure(s)

For candidate cluster 1, location 0 - 37060:

Rough prediction of core scaffold based on assumed PKS linker matching; tailoring reactions not taken into account

Polymer prediction:: (mal) + (Me-redmal) + (Me-ohmal) + (Me-redmal) + (Me-ohmal)
Non-colinear ordering:: ebeA + ebeB + ebeC + ebeF + ebeG

Direct lookup in NORINE database: strict or relaxed

Link to NORINE database query form

NRPS/PKS monomer predictions

ebeA

PKS_AT (441..755): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 91.7%; inactive: 70.8%; Methylmalonyl-CoA: 58.3%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 201.8
inactive: 76.8
Methoxymalonyl-CoA: 64.0
Methylmalonyl-CoA: 60.0
Propionyl-CoA: 30.7
Acetyl-CoA: 22.0
Ethylmalonyl-CoA: 21.1
Benzoyl-CoA: 20.5
Isobutyryl-CoA: 18.0
fatty_acid: 10.9
2-Methylbutyryl-CoA: 9.6
CHC-CoA: 7.6
trans-1,2-CPDA: 0.0
3-Methylbutyryl-CoA: 0.0

ebeB

PKS_AT (571..869): mmal

ATSignature: Methylmalonyl-CoA

Top 3 matches:: Methylmalonyl-CoA: 100.0%; Methoxymalonyl-CoA: 95.8%; Ethylmalonyl-CoA: 91.7%

minowa: Methylmalonyl-CoA

Prediction, score:

Methylmalonyl-CoA: 220.4
Ethylmalonyl-CoA: 208.8
Methoxymalonyl-CoA: 182.1
2-Methylbutyryl-CoA: 136.4
trans-1,2-CPDA: 122.7
Propionyl-CoA: 112.7
Isobutyryl-CoA: 100.4
Malonyl-CoA: 97.0
CHC-CoA: 97.0
Benzoyl-CoA: 74.9
3-Methylbutyryl-CoA: 52.7
Acetyl-CoA: 51.2
inactive: 33.4
fatty_acid: 28.8

ebeC

PKS_AT (568..866): mmal

ATSignature: Methylmalonyl-CoA

Top 3 matches:: Methylmalonyl-CoA: 100.0%; Methoxymalonyl-CoA: 95.8%; Ethylmalonyl-CoA: 91.7%

minowa: Methylmalonyl-CoA

Prediction, score:

Methylmalonyl-CoA: 222.3
Ethylmalonyl-CoA: 210.7
Methoxymalonyl-CoA: 184.2
2-Methylbutyryl-CoA: 141.8
trans-1,2-CPDA: 126.7
Propionyl-CoA: 115.0
Malonyl-CoA: 100.6
Isobutyryl-CoA: 100.2
CHC-CoA: 97.3
Benzoyl-CoA: 74.1
3-Methylbutyryl-CoA: 57.0
Acetyl-CoA: 50.9
inactive: 34.6
fatty_acid: 29.7

ebeF

PKS_AT (824..1121): mmal

ATSignature: Methylmalonyl-CoA

Top 3 matches:: Methylmalonyl-CoA: 100.0%; Methoxymalonyl-CoA: 91.7%; Ethylmalonyl-CoA: 87.5%

minowa: Methylmalonyl-CoA

Prediction, score:

Methylmalonyl-CoA: 217.3
Ethylmalonyl-CoA: 216.0
Methoxymalonyl-CoA: 184.0
2-Methylbutyryl-CoA: 152.7
trans-1,2-CPDA: 146.2
Propionyl-CoA: 115.1
CHC-CoA: 108.1
Isobutyryl-CoA: 92.1
Malonyl-CoA: 88.4
Benzoyl-CoA: 79.1
Acetyl-CoA: 56.4
3-Methylbutyryl-CoA: 53.1
fatty_acid: 43.9
inactive: 30.6

ebeG

PKS_AT (564..861): mmal

ATSignature: Methylmalonyl-CoA, Ethylmalonyl-CoA, Methoxymalonyl-CoA

Top 3 matches:: Methylmalonyl-CoA: 87.5%; Ethylmalonyl-CoA: 87.5%; Methoxymalonyl-CoA: 87.5%

minowa: Methylmalonyl-CoA

Prediction, score:

Methylmalonyl-CoA: 199.1
Ethylmalonyl-CoA: 199.1
Methoxymalonyl-CoA: 173.9
2-Methylbutyryl-CoA: 140.8
trans-1,2-CPDA: 126.4
Propionyl-CoA: 106.3
CHC-CoA: 102.6
Malonyl-CoA: 99.2
Isobutyryl-CoA: 93.5
Benzoyl-CoA: 78.9
fatty_acid: 43.4
Acetyl-CoA: 39.7
inactive: 35.1
3-Methylbutyryl-CoA: 27.7

orf1

Search NORINE for peptide: strict or relaxed

AMP-binding (19..457): X

NRPSPredictor2: (unknown)

SVM prediction details:

NOTE: outside applicability domain

Predicted physicochemical class:: hydrophobic-aliphatic
Large clusters prediction:: N/A
Small clusters prediction:: val, leu, ile, abu, iva
Single AA prediction:: N/A

Stachelhaus prediction details:

Stachelhaus sequence:: --WfVAApiK
Nearest Stachelhaus code:: phe
Stachelhaus code match:: 50% (weak)