BGC0000087 - 1 region(s) - antiSMASH results

Identified secondary metabolite regions using strictness 'relaxed'

BGC0000087 (Streptomyces lasalocidi)

Region	Type	From	To	Most similar known cluster		Similarity
Region 1	T1PKS	1	110,927	lasalocid	Polyketide	75%

BGC0000087 - Region 1 - T1PKS

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Location: 1 - 110,927 nt. (total: 110,927 nt) Show pHMM detection rules used

Region on contig edge.

T1PKS: cds(PKS_AT and (PKS_KS or ene_KS or mod_KS or hyb_KS or itr_KS or tra_KS))

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core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

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TTA codons

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Gene details

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MIBiG

NRPS/PKS domains

MIBiG comparison

KnownClusterBlast

NRPS/PKS modules

External annotation

Name		MIBiG
Version		3.0

Type		Subregion
Location		1 - 110,928
Label		BGC0000087

Detailed domain annotation

Selected features only

Show module domains

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000087.1	0.68	Polyketide	lasalocid	Streptomyces lasaliensis
BGC0000086.1	0.57	Polyketide	lasalocid	Streptomyces lasaliensis
BGC0001735.1	0.39	Other	pentostatine, vidarabine	Streptomyces antibioticus
BGC0000041.1	0.35	Polyketide	oronofacic acid	Pseudomonas syringae
BGC0001648.1	0.34	Polyketide	lasalocid	Streptomyces sp.
BGC0001913.1	0.31	Polyketide	phomoidride	fungal sp. ATCC 74256
BGC0001273.1	0.31	Polyketide	asperlactone	Aspergillus ochraceus
BGC0001244.1	0.31	Polyketide	(-)-Mellein	Parastagonospora nodorum
BGC0001276.1	0.30	Polyketide	6-methylsalicyclic acid	Aspergillus terreus
BGC0000122.1	0.30	Polyketide	phenylnannolone A, phenylnannolone B, phenylnannolone C	Nannocystis pusilla

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000087.1	0.91	Polyketide	lasalocid	Streptomyces lasaliensis
BGC0000086.1	0.83	Polyketide	lasalocid	Streptomyces lasaliensis
BGC0000041.1	0.68	Polyketide	oronofacic acid	Pseudomonas syringae
BGC0001648.1	0.67	Polyketide	lasalocid	Streptomyces sp.
BGC0001913.1	0.64	Polyketide	phomoidride	fungal sp. ATCC 74256
BGC0001273.1	0.64	Polyketide	asperlactone	Aspergillus ochraceus
BGC0001244.1	0.64	Polyketide	(-)-Mellein	Parastagonospora nodorum
BGC0001276.1	0.64	Polyketide	6-methylsalicyclic acid	Aspergillus terreus
BGC0000122.1	0.64	Polyketide	phenylnannolone A, phenylnannolone B, phenylnannolone C	Nannocystis pusilla
BGC0001340.1	0.64	Polyketide	byssochlamic acid	Byssochlamys fulva

Similar known gene clusters

Module view

Legend

NRPS/PKS products

NRPS/PKS monomers

Predicted core structure(s)

For candidate cluster 1, location 0 - 100106:

Rough prediction of core scaffold based on assumed PKS linker matching; tailoring reactions not taken into account

Polymer prediction:: (mal - pk - redmal) + (pk - Me-redmal - pk) + (Me-ohmal) + (redmal - ohmal) + (Me-ccmal) + (Me-mal) + (mal)
Non-colinear ordering:: lasAI + lasAII + lasAIV + lasAV + lasAVI + lasAIII + lasAVII

Direct lookup in NORINE database: strict or relaxed

Link to NORINE database query form

NRPS/PKS monomer predictions

lasAI

PKS_AT (536..835): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 100.0%; inactive: 87.5%; 2-Rhyd-Malonyl-CoA: 58.3%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 232.3
inactive: 106.5
Methoxymalonyl-CoA: 83.3
Methylmalonyl-CoA: 66.9
Propionyl-CoA: 52.9
Isobutyryl-CoA: 43.2
Ethylmalonyl-CoA: 30.0
2-Methylbutyryl-CoA: 29.3
Benzoyl-CoA: 22.7
fatty_acid: 20.6
Acetyl-CoA: 20.3
CHC-CoA: 14.7
3-Methylbutyryl-CoA: 13.0
trans-1,2-CPDA: 0.0

PKS_AT (1582..1873): pk

ATSignature: Ethylmalonyl-CoA

Top 3 matches:: Ethylmalonyl-CoA: 100.0%; Methoxymalonyl-CoA: 87.5%; Methylmalonyl-CoA: 79.2%

minowa: Methylmalonyl-CoA

Prediction, score:

Methylmalonyl-CoA: 185.3
Ethylmalonyl-CoA: 173.6
Methoxymalonyl-CoA: 150.1
2-Methylbutyryl-CoA: 119.3
trans-1,2-CPDA: 115.1
CHC-CoA: 106.5
Malonyl-CoA: 98.8
Propionyl-CoA: 90.6
Isobutyryl-CoA: 67.7
Benzoyl-CoA: 34.3
fatty_acid: 31.4
inactive: 30.3
Acetyl-CoA: 27.2
3-Methylbutyryl-CoA: 24.8

PKS_AT (3385..3671): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 100.0%; inactive: 83.3%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 189.8
inactive: 87.2
Methoxymalonyl-CoA: 49.0
Methylmalonyl-CoA: 34.4
Propionyl-CoA: 27.2
Acetyl-CoA: 17.7
fatty_acid: 17.5
Benzoyl-CoA: 14.7
trans-1,2-CPDA: 14.0
Isobutyryl-CoA: 12.3
2-Methylbutyryl-CoA: 9.4
CHC-CoA: 7.1
Ethylmalonyl-CoA: 6.0
3-Methylbutyryl-CoA: 0.0

lasAII

PKS_AT (566..857): pk

ATSignature: Ethylmalonyl-CoA

Top 3 matches:: Ethylmalonyl-CoA: 100.0%; Methoxymalonyl-CoA: 87.5%; Methylmalonyl-CoA: 79.2%

minowa: Methylmalonyl-CoA

Prediction, score:

Methylmalonyl-CoA: 187.0
Ethylmalonyl-CoA: 175.0
Methoxymalonyl-CoA: 152.0
2-Methylbutyryl-CoA: 118.5
trans-1,2-CPDA: 116.8
CHC-CoA: 105.1
Malonyl-CoA: 97.8
Propionyl-CoA: 90.6
Isobutyryl-CoA: 64.8
Benzoyl-CoA: 34.7
fatty_acid: 30.8
inactive: 30.6
Acetyl-CoA: 27.0
3-Methylbutyryl-CoA: 26.9

PKS_AT (2323..2620): mmal

ATSignature: Methylmalonyl-CoA

Top 3 matches:: Methylmalonyl-CoA: 100.0%; Methoxymalonyl-CoA: 95.8%; Ethylmalonyl-CoA: 91.7%

minowa: Methylmalonyl-CoA

Prediction, score:

Methylmalonyl-CoA: 200.7
Ethylmalonyl-CoA: 186.2
Methoxymalonyl-CoA: 160.7
2-Methylbutyryl-CoA: 133.6
trans-1,2-CPDA: 124.5
CHC-CoA: 97.3
Propionyl-CoA: 95.5
Malonyl-CoA: 80.7
Isobutyryl-CoA: 58.1
Benzoyl-CoA: 45.4
3-Methylbutyryl-CoA: 23.5
Acetyl-CoA: 17.5
fatty_acid: 16.4
inactive: 13.9

PKS_AT (4389..4680): pk

ATSignature: Ethylmalonyl-CoA

Top 3 matches:: Ethylmalonyl-CoA: 100.0%; Methoxymalonyl-CoA: 87.5%; Methylmalonyl-CoA: 79.2%

minowa: Methylmalonyl-CoA

Prediction, score:

Methylmalonyl-CoA: 186.2
Ethylmalonyl-CoA: 174.2
Methoxymalonyl-CoA: 151.1
2-Methylbutyryl-CoA: 123.7
trans-1,2-CPDA: 111.6
CHC-CoA: 106.7
Malonyl-CoA: 99.3
Propionyl-CoA: 90.6
Isobutyryl-CoA: 68.0
Benzoyl-CoA: 34.2
inactive: 32.8
fatty_acid: 31.2
Acetyl-CoA: 24.8
3-Methylbutyryl-CoA: 24.5

lasAIII

PKS_AT (564..861): mmal

ATSignature: Methylmalonyl-CoA

Top 3 matches:: Methylmalonyl-CoA: 100.0%; Methoxymalonyl-CoA: 95.8%; Ethylmalonyl-CoA: 91.7%

minowa: Methylmalonyl-CoA

Prediction, score:

Methylmalonyl-CoA: 197.1
Ethylmalonyl-CoA: 183.6
Methoxymalonyl-CoA: 156.0
2-Methylbutyryl-CoA: 131.7
trans-1,2-CPDA: 122.6
Propionyl-CoA: 94.1
CHC-CoA: 93.9
Malonyl-CoA: 78.9
Isobutyryl-CoA: 58.2
Benzoyl-CoA: 44.5
3-Methylbutyryl-CoA: 22.0
Acetyl-CoA: 18.9
fatty_acid: 15.4
inactive: 12.3

lasAIV

PKS_AT (567..864): mmal

ATSignature: Methylmalonyl-CoA

Top 3 matches:: Methylmalonyl-CoA: 100.0%; Methoxymalonyl-CoA: 95.8%; Ethylmalonyl-CoA: 91.7%

minowa: Methylmalonyl-CoA

Prediction, score:

Methylmalonyl-CoA: 192.4
Ethylmalonyl-CoA: 178.6
Methoxymalonyl-CoA: 152.3
2-Methylbutyryl-CoA: 131.3
trans-1,2-CPDA: 119.9
Propionyl-CoA: 94.2
CHC-CoA: 91.8
Malonyl-CoA: 77.0
Isobutyryl-CoA: 54.5
Benzoyl-CoA: 46.6
Acetyl-CoA: 22.4
3-Methylbutyryl-CoA: 21.6
fatty_acid: 17.1
inactive: 11.4

lasAV

PKS_AT (564..850): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 100.0%; inactive: 83.3%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 180.5
inactive: 81.5
Methoxymalonyl-CoA: 43.8
Methylmalonyl-CoA: 29.9
Propionyl-CoA: 22.4
Acetyl-CoA: 15.2
fatty_acid: 12.5
2-Methylbutyryl-CoA: 12.1
Benzoyl-CoA: 11.9
Isobutyryl-CoA: 11.7
trans-1,2-CPDA: 9.8
CHC-CoA: 0.5
Ethylmalonyl-CoA: 0.0
3-Methylbutyryl-CoA: 0.0

PKS_AT (2654..2939): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 100.0%; inactive: 83.3%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 180.2
inactive: 81.2
Methoxymalonyl-CoA: 42.4
Methylmalonyl-CoA: 30.7
Propionyl-CoA: 23.0
Acetyl-CoA: 15.2
fatty_acid: 12.5
2-Methylbutyryl-CoA: 12.1
CHC-CoA: 12.0
Benzoyl-CoA: 11.9
Isobutyryl-CoA: 11.7
trans-1,2-CPDA: 11.3
Ethylmalonyl-CoA: 0.0
3-Methylbutyryl-CoA: 0.0

lasAVI

PKS_AT (578..875): mmal

ATSignature: Methylmalonyl-CoA

Top 3 matches:: Methylmalonyl-CoA: 100.0%; Methoxymalonyl-CoA: 95.8%; Ethylmalonyl-CoA: 91.7%

minowa: Methylmalonyl-CoA

Prediction, score:

Methylmalonyl-CoA: 196.4
Ethylmalonyl-CoA: 182.0
Methoxymalonyl-CoA: 155.0
2-Methylbutyryl-CoA: 138.1
trans-1,2-CPDA: 121.6
Propionyl-CoA: 96.9
CHC-CoA: 93.7
Malonyl-CoA: 81.3
Isobutyryl-CoA: 55.4
Benzoyl-CoA: 50.2
3-Methylbutyryl-CoA: 25.4
fatty_acid: 21.6
Acetyl-CoA: 18.1
inactive: 14.7

lasAVII

PKS_AT (566..845): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 100.0%; inactive: 83.3%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 184.5
inactive: 82.7
Methoxymalonyl-CoA: 43.7
Methylmalonyl-CoA: 30.1
Propionyl-CoA: 23.1
Acetyl-CoA: 14.9
fatty_acid: 13.9
Benzoyl-CoA: 12.1
Isobutyryl-CoA: 12.0
trans-1,2-CPDA: 9.7
2-Methylbutyryl-CoA: 8.9
CHC-CoA: 6.0
Ethylmalonyl-CoA: 0.0
3-Methylbutyryl-CoA: 0.0