BGC0000102 - 1 region(s) - antiSMASH results

Identified secondary metabolite regions using strictness 'relaxed'

BGC0000102 (Micromonospora griseorubida)

Region	Type	From	To	Most similar known cluster		Similarity
Region 1	T1PKS	1	58,343	10,11-dihydro-8-deoxy-12,13-deepoxy-12,13-dihydrochalcomycin	Polyketide	54%

BGC0000102 - Region 1 - T1PKS

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Location: 1 - 58,343 nt. (total: 58,343 nt) Show pHMM detection rules used

Region on contig edge.

T1PKS: cds(PKS_AT and (PKS_KS or ene_KS or mod_KS or hyb_KS or itr_KS or tra_KS))

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core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

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resistance

TTA codons

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Gene details

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MIBiG

NRPS/PKS domains

MIBiG comparison

KnownClusterBlast

NRPS/PKS modules

External annotation

Name		MIBiG
Version		3.0

Type		Subregion
Location		1 - 58,344
Label		BGC0000102

Detailed domain annotation

Selected features only

Show module domains

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000102.1	0.67	Polyketide	mycinamicin II	Micromonospora griseorubida
BGC0000018.1	0.37	Polyketide	angolamycin	Streptomyces eurythermus
BGC0001909.1	0.32	Polyketide	strobilurin	Strobilurus tenacellus
BGC0001280.1	0.29	Polyketide	betaenone C, betaenone A	Phoma betae
BGC0001264.1	0.29	Polyketide	betaenone A, betaenone B, betaenone C	Phoma betae
BGC0000041.1	0.28	Polyketide	oronofacic acid	Pseudomonas syringae
BGC0001858.1	0.28	Polyketide	alternapyrone B, alternapyrone C, alternapyrone D, alternapyrone E, alternapyrone F	Parastagonospora nodorum SN15
BGC0000113.1	0.28	Polyketide	niddamycin	Streptomyces caelestis
BGC0001104.1	0.27	NRP, Polyketide	myxovirescin A1	Myxococcus xanthus DK 1622
BGC0000201.1	0.27	Polyketide, Saccharide	auricin	Streptomyces aureofaciens

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000102.1	0.87	Polyketide	mycinamicin II	Micromonospora griseorubida
BGC0000018.1	0.70	Polyketide	angolamycin	Streptomyces eurythermus
BGC0001909.1	0.65	Polyketide	strobilurin	Strobilurus tenacellus
BGC0001280.1	0.63	Polyketide	betaenone C, betaenone A	Phoma betae
BGC0001264.1	0.63	Polyketide	betaenone A, betaenone B, betaenone C	Phoma betae
BGC0000041.1	0.62	Polyketide	oronofacic acid	Pseudomonas syringae
BGC0001858.1	0.61	Polyketide	alternapyrone B, alternapyrone C, alternapyrone D, alternapyrone E, alternapyrone F	Parastagonospora nodorum SN15
BGC0000113.1	0.61	Polyketide	niddamycin	Streptomyces caelestis
BGC0001104.1	0.61	NRP, Polyketide	myxovirescin A1	Myxococcus xanthus DK 1622
BGC0000201.1	0.61	Polyketide, Saccharide	auricin	Streptomyces aureofaciens

Similar known gene clusters

Module view

Legend

NRPS/PKS products

NRPS/PKS monomers

Predicted core structure(s)

For candidate cluster 1, location 0 - 58343:

Rough prediction of core scaffold based on assumed PKS linker matching; tailoring reactions not taken into account

Polymer prediction:: (pk - Me-ohmal - ccmal) + (ccmal) + (Me-ohmal) + (Me-ccmal - Me-redmal) + (ccmal)
Non-colinear ordering:: mycAI + mycAII + mycAIV + mycAIII + mycAV

Direct lookup in NORINE database: strict or relaxed

Link to NORINE database query form

NRPS/PKS monomer predictions

mycAI

PKS_AT (507..806): pk

ATSignature: Methylmalonyl-CoA

Top 3 matches:: Methylmalonyl-CoA: 100.0%; Methoxymalonyl-CoA: 87.5%; Malonyl-CoA: 87.5%

minowa: Ethylmalonyl-CoA

Prediction, score:

Ethylmalonyl-CoA: 208.3
Methylmalonyl-CoA: 208.2
Methoxymalonyl-CoA: 163.7
2-Methylbutyryl-CoA: 130.6
trans-1,2-CPDA: 122.9
Propionyl-CoA: 94.7
Malonyl-CoA: 91.0
Isobutyryl-CoA: 87.0
CHC-CoA: 85.5
Benzoyl-CoA: 70.3
Acetyl-CoA: 48.8
fatty_acid: 27.7
inactive: 21.6
3-Methylbutyryl-CoA: 16.8

PKS_AT (1530..1817): mmal

ATSignature: Methylmalonyl-CoA

Top 3 matches:: Methylmalonyl-CoA: 100.0%; Methoxymalonyl-CoA: 79.2%; Malonyl-CoA: 79.2%

minowa: Methylmalonyl-CoA

Prediction, score:

Methylmalonyl-CoA: 168.2
Ethylmalonyl-CoA: 134.0
Methoxymalonyl-CoA: 117.9
2-Methylbutyryl-CoA: 91.5
trans-1,2-CPDA: 86.3
CHC-CoA: 82.3
Propionyl-CoA: 71.8
Malonyl-CoA: 53.3
Isobutyryl-CoA: 41.8
Benzoyl-CoA: 25.0
fatty_acid: 23.4
Acetyl-CoA: 21.4
3-Methylbutyryl-CoA: 20.1
inactive: 0.0

PKS_AT (3006..3306): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 100.0%; inactive: 83.3%; 2-Rhyd-Malonyl-CoA: 58.3%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 209.0
inactive: 107.7
Methoxymalonyl-CoA: 68.4
Methylmalonyl-CoA: 65.6
Propionyl-CoA: 45.7
Isobutyryl-CoA: 25.3
Ethylmalonyl-CoA: 22.6
2-Methylbutyryl-CoA: 21.8
CHC-CoA: 18.7
Acetyl-CoA: 17.8
fatty_acid: 15.3
Benzoyl-CoA: 13.6
trans-1,2-CPDA: 13.1
3-Methylbutyryl-CoA: 4.9

mycAII

PKS_AT (574..869): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 100.0%; inactive: 79.2%; 2-Rhyd-Malonyl-CoA: 58.3%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 195.0
inactive: 92.8
Methoxymalonyl-CoA: 73.4
Methylmalonyl-CoA: 64.7
Isobutyryl-CoA: 37.3
Ethylmalonyl-CoA: 31.2
Propionyl-CoA: 30.2
Acetyl-CoA: 22.0
2-Methylbutyryl-CoA: 21.7
CHC-CoA: 19.9
Benzoyl-CoA: 19.2
trans-1,2-CPDA: 11.8
fatty_acid: 11.1
3-Methylbutyryl-CoA: 0.0

mycAIII

PKS_AT (592..892): mmal

ATSignature: Methylmalonyl-CoA

Top 3 matches:: Methylmalonyl-CoA: 100.0%; Methoxymalonyl-CoA: 79.2%; Malonyl-CoA: 79.2%

minowa: Methylmalonyl-CoA

Prediction, score:

Methylmalonyl-CoA: 175.9
Ethylmalonyl-CoA: 151.5
Methoxymalonyl-CoA: 129.8
CHC-CoA: 98.3
2-Methylbutyryl-CoA: 89.3
trans-1,2-CPDA: 88.4
Propionyl-CoA: 77.6
Malonyl-CoA: 58.3
Isobutyryl-CoA: 46.6
Benzoyl-CoA: 37.0
3-Methylbutyryl-CoA: 28.9
Acetyl-CoA: 28.0
fatty_acid: 25.0
inactive: 9.4

PKS_AT (2037..2337): mmal

ATSignature: Methylmalonyl-CoA

Top 3 matches:: Methylmalonyl-CoA: 100.0%; Methoxymalonyl-CoA: 79.2%; Malonyl-CoA: 79.2%

minowa: Methylmalonyl-CoA

Prediction, score:

Methylmalonyl-CoA: 174.0
Ethylmalonyl-CoA: 146.4
Methoxymalonyl-CoA: 128.5
CHC-CoA: 96.6
2-Methylbutyryl-CoA: 87.5
trans-1,2-CPDA: 87.4
Propionyl-CoA: 77.1
Malonyl-CoA: 63.0
Isobutyryl-CoA: 44.5
Benzoyl-CoA: 32.8
3-Methylbutyryl-CoA: 29.3
fatty_acid: 26.3
Acetyl-CoA: 21.5
inactive: 0.0

mycAIV

PKS_AT (579..880): mmal

ATSignature: Methylmalonyl-CoA

Top 3 matches:: Methylmalonyl-CoA: 100.0%; Methoxymalonyl-CoA: 79.2%; Malonyl-CoA: 79.2%

minowa: Methylmalonyl-CoA

Prediction, score:

Methylmalonyl-CoA: 168.4
Ethylmalonyl-CoA: 139.3
Methoxymalonyl-CoA: 124.3
CHC-CoA: 88.3
trans-1,2-CPDA: 87.1
2-Methylbutyryl-CoA: 86.9
Propionyl-CoA: 78.4
Malonyl-CoA: 61.3
Isobutyryl-CoA: 43.8
Benzoyl-CoA: 28.9
Acetyl-CoA: 28.0
fatty_acid: 25.3
3-Methylbutyryl-CoA: 22.7
inactive: 10.7

mycAV

PKS_AT (570..869): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 100.0%; inactive: 75.0%; 2-Rhyd-Malonyl-CoA: 54.2%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 206.8
inactive: 104.2
Methoxymalonyl-CoA: 69.3
Methylmalonyl-CoA: 60.0
Propionyl-CoA: 40.2
2-Methylbutyryl-CoA: 22.5
Ethylmalonyl-CoA: 21.8
Acetyl-CoA: 18.8
CHC-CoA: 14.3
Benzoyl-CoA: 13.9
Isobutyryl-CoA: 11.1
fatty_acid: 10.7
trans-1,2-CPDA: 0.0
3-Methylbutyryl-CoA: 0.0