BGC0000134 - 1 region(s) - antiSMASH results

Identified secondary metabolite regions using strictness 'relaxed'

BGC0000134 (Pochonia chlamydosporia (Metacordyceps chlamydosporia))

Region	Type	From	To	Similarity Confidence	Most similar known cluster
Region 1	T1PKS	1	31,332	High	radicicol	PKS

BGC0000134 - Region 1 - T1PKS

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Location: 1 - 31,332 nt. (total: 31,332 nt) Show pHMM detection rules used

Region on contig edge.

T1PKS: cds(PKS_AT and (PKS_KS or ene_KS or mod_KS or hyb_KS or itr_KS or tra_KS))

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core biosynthetic genes

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Gene details

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Gene overview

MIBiG

Tailoring

MIBiG comparison

KnownClusterBlast

NRPS/PKS modules

NRPS/PKS domains

Gene/CDS overview

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Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

External annotation

Name		MIBiG
Version		4.0alpha

Type		Subregion
Location		1 - 31,333
Label		BGC0000134

Tailoring functions

Oxidoreductases: oxygenase

Rdc4: cytochrome P450

smcogs: SMCOG1034: cytochrome P450

Transferases: halogenase

Rdc2: conventional flavin-dependent halogenase

halogenases: conventional flavin-dependent halogenase
smcogs: SMCOG1119: halogenase

Ligases: synthase

Rdc1: Beta-ketoacyl synthase

smcogs: SMCOG1093: Beta-ketoacyl synthase

Rdc5: Beta-ketoacyl synthase

smcogs: SMCOG1093: Beta-ketoacyl synthase

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000134.3	1.00	PKS	radicicol	Pochonia chlamydosporia
BGC0002187.3	0.90	PKS	monorden D, monocillin IV, monocillin VI, monocillin VII, pochonin M, monocillin V, monocillin II	Pochonia chlamydosporia 170
BGC0002608.2	0.79	NRPS, PKS	ochratoxin A	Aspergillus steynii
BGC0001258.3	0.66	PKS	1,3,6,8-tetrahydroxynaphthalene	Glarea lozoyensis
BGC0002154.2	0.66	PKS	1,3,5,8-tetrahydroxynapthalene, 1-(alpha-l-(2-O-methyl)-6-deoxymannopyranosyloxy)-3,6,8-trimethoxynaphthalene	Pyricularia oryzae 70-15
BGC0002175.3	0.66	PKS	YWA1	Aspergillus oryzae RIB40
BGC0001257.3	0.66	PKS	1,3,6,8-tetrahydroxynaphthalene	Nodulisporium sp. ATCC74245
BGC0000107.3	0.66	PKS	naphthopyrone	Aspergillus nidulans FGSC A4
BGC0002191.2	0.66	PKS	prolipyrone B, gibepyrone D	Fusarium graminearum PH-1
BGC0001284.4	0.66	PKS	alternariol	Parastagonospora nodorum SN15

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000134.3	1.00	PKS	radicicol	Pochonia chlamydosporia
BGC0002187.3	0.90	PKS	monorden D, monocillin IV, monocillin VI, monocillin VII, pochonin M, monocillin V, monocillin II	Pochonia chlamydosporia 170
BGC0002608.2	0.79	NRPS, PKS	ochratoxin A	Aspergillus steynii
BGC0001258.3	0.66	PKS	1,3,6,8-tetrahydroxynaphthalene	Glarea lozoyensis
BGC0002154.2	0.66	PKS	1,3,5,8-tetrahydroxynapthalene, 1-(alpha-l-(2-O-methyl)-6-deoxymannopyranosyloxy)-3,6,8-trimethoxynaphthalene	Pyricularia oryzae 70-15
BGC0002175.3	0.66	PKS	YWA1	Aspergillus oryzae RIB40
BGC0001257.3	0.66	PKS	1,3,6,8-tetrahydroxynaphthalene	Nodulisporium sp. ATCC74245
BGC0000107.3	0.66	PKS	naphthopyrone	Aspergillus nidulans FGSC A4
BGC0002191.2	0.66	PKS	prolipyrone B, gibepyrone D	Fusarium graminearum PH-1
BGC0001284.4	0.66	PKS	alternariol	Parastagonospora nodorum SN15

Similar known clusters from MIBiG 4.0

Module view

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Detailed domain annotation

Selected features only

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NRPS/PKS products

NRPS/PKS substrates

Predicted core structure(s)

For candidate cluster 1, location 0 - 31332:

Rough prediction of core scaffold based on assumed PKS linker matching; tailoring reactions not taken into account

Polymer prediction:: (pk) + (mal)
Non-colinear ordering:: Rdc5 + Rdc1

Direct lookup in NORINE database: strict or relaxed

Link to NORINE database query form

NRPS/PKS substrate predictions

Rdc1: mal

PKS_AT (913..1209): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 62.5%; Methylmalonyl-CoA: 58.3%; inactive: 54.2%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 95.8
Methoxymalonyl-CoA: 62.5
inactive: 58.9
Methylmalonyl-CoA: 48.6
Isobutyryl-CoA: 43.4
Benzoyl-CoA: 30.7
Propionyl-CoA: 25.6
2-Methylbutyryl-CoA: 23.9
Acetyl-CoA: 22.7
Ethylmalonyl-CoA: 21.9
CHC-CoA: 20.6
fatty_acid: 20.5
3-Methylbutyryl-CoA: 19.0
trans-1,2-CPDA: 17.1

Rdc5: pk

PKS_AT (550..862): pk

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 87.5%; Methylmalonyl-CoA: 70.8%; 2-Methylbutyryl-CoA: 62.5%

minowa: Methylmalonyl-CoA

Prediction, score:

Methylmalonyl-CoA: 91.4
Methoxymalonyl-CoA: 79.3
Malonyl-CoA: 61.7
Ethylmalonyl-CoA: 60.3
Isobutyryl-CoA: 53.5
Benzoyl-CoA: 48.1
Propionyl-CoA: 30.6
2-Methylbutyryl-CoA: 27.8
CHC-CoA: 26.3
trans-1,2-CPDA: 25.5
3-Methylbutyryl-CoA: 17.9
fatty_acid: 16.8
inactive: 15.4
Acetyl-CoA: 7.0

Link to PARAS substrate predictor