BGC0000200: arixanthomycin A biosynthetic gene cluster from uncultured bacterium
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Location: 1 - 31,965 nt. (total: 31,965 nt).
This entry is originally from NCBI GenBank KF931341.1.

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core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
TTA codons
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General
Compounds
Genes
Biosynthesis
History
KnownClusterBlast
NRPS/PKS domains
General information about the BGC
MIBiG accession BGC0000200
Short description arixanthomycin A biosynthetic gene cluster from uncultured bacterium
Status Quality: questionable
The quality level of this entry.

Status: active
The status of this entry.

Completeness: complete
Whether the entry covers everything needed for the pathway producing the compound(s)
Biosynthetic class(es)
  • PKS (Type II)
  • saccharide (hybrid/tailoring)
Loci
KF931341.1
via Heterologous expression
Compounds
  • arixanthomycin A
  • arixanthomycin B
  • arixanthomycin C
Species uncultured bacterium [taxonomy]
References
Chemical products information
arixanthomycin A Evidence:
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C37H37N1O14
arixanthomycin B Evidence:
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C29H23N1O9
arixanthomycin C Evidence:
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C28H21N1O9
List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Extra
  • arx1
  • AHX24686.1
 1 - 1059 (-) NAD-dependent epimerase/dehydratase
  • Tailoring
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  • arx2
  • AHX24687.1
 1062 - 1796 (-) hypothetical protein
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    • arx3
    • AHX24688.1
    		 1822 - 2988 (-) glycosyltransferase
    • Tailoring
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    • arx4
    • AHX24689.1
    		 3207 - 3887 (+) short-chain dehydrogenase/reductase SDR
    • Precursor biosynthesis
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    • arx5
    • AHX24690.1
    		 3911 - 5761 (+) amidotransferase
    • Tailoring
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    • arx6
    • AHX24691.1
    		 5791 - 6855 (+) O-methyltransferase
    • Tailoring
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    • arx7
    • AHX24692.1
    		 6917 - 7744 (-) ABC transporter
    • Transport
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    • arx8
    • AHX24693.1
    		 7741 - 8697 (-) ABC transporter ATP-binding protein
    • Transport
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    • arx9
    • AHX24694.1
    		 8694 - 9872 (-) glycosyltransferase
    • Tailoring
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    • arx10
    • AHX24695.1
    		 9874 - 11460 (-) FAD-binding monooxygenase
    • Tailoring
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    • arx11
    • AHX24696.1
    		 12253 - 13065 (-) hypothetical protein
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      • arx12
      • AHX24697.1
      		 13091 - 14125 (-) O-methyltransferase
      • Tailoring
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      • arx13
      • AHX24698.1
      		 14331 - 15218 (+) dehydrogenase
      • Tailoring
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      • arx14
      • AHX24699.1
      		 15240 - 15575 (+) cyclase
      • Scaffold biosynthesis
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      • arx15
      • AHX24700.1
      		 15572 - 16003 (+) cyclase
      • Scaffold biosynthesis
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      • arx16
      • AHX24701.1
      		 16000 - 17268 (+) beta-ketoacyl synthase alpha
      • Scaffold biosynthesis
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      • arx17
      • AHX24702.1
      		 17272 - 18510 (+) beta-ketoacyl synthase beta
      • Scaffold biosynthesis
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      • arx18
      • AHX24703.1
      		 18510 - 18773 (+) acyl carrier protein
      • Scaffold biosynthesis
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      • arx19
      • AHX24704.1
      		 18775 - 19236 (+) cyclase
      • Scaffold biosynthesis
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      • arx20
      • AHX24705.1
      		 19243 - 19701 (+) monooxygenase
      • Tailoring
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      • arx21
      • AHX24706.1
      		 19725 - 20483 (+) 3-oxoacyl-ACP reductase
      • Tailoring
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      • arx22
      • AHX24707.1
      		 20483 - 20836 (+) monooxygenase
      • Tailoring
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      • arx23
      • AHX24708.1
      		 20833 - 21144 (+) monooxygenase
      • Tailoring
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      • arx24
      • AHX24709.1
      		 21158 - 21961 (+) NDP-4-ketoreductase
      • Tailoring
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      • arx25
      • AHX24710.1
      		 22020 - 22475 (-) hypothetical protein
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        • arx26
        • AHX24711.1
        		 22478 - 22858 (-) hypothetical protein
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          • arx27
          • AHX24712.1
          		 22858 - 23595 (-) 3-oxoacyl-ACP reductase
          • Tailoring
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          • arx28
          • AHX24713.1
          		 23592 - 25082 (-) putative peptide transporter
          • Transport
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          • arx29
          • AHX24714.1
          		 25098 - 25478 (-) CurD-like protein
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            • arx30
            • AHX24715.1
            		 25490 - 27076 (-) FAD-binding monooxygenase
            • Tailoring
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            • arx31
            • AHX24716.1
            		 27260 - 27943 (-) LuxR family transcriptional regulator
            • Regulation
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            • arx32
            • AHX24717.1
            		 27940 - 29121 (-) two-component system histidine kinase
            • Regulation
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            • arx33
            • AHX24718.1
            		 29300 - 30136 (+) F420-dependent reductase
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              • arx34
              • AHX24719.1
              		 30183 - 31214 (+) putative methyltransferase
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                • arx35
                • AHX24720.1
                		 31436 - 31963 (+) biotin carboxyl carrier protein
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                  Biosynthesis information

                  No biosynthesis information available for this record.

                  Annotation changelog

                  Entry version: 4

                  Date
                  Changes
                  Submitters
                  Reviewers
                  2022-10-07
                  Update chemical activity to schema version 2.11
                  • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                  • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                  Entry version: 3

                  Date
                  Changes
                  Submitters
                  Reviewers
                  2022-09-15
                  Removed gene names of 'No gene ID'
                  • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                  • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                  2022-09-15
                  Updated bioactivity data
                  • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                  • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                  Entry version: 2

                  Date
                  Changes
                  Submitters
                  Reviewers
                  2019-10-16
                  Migrated from v1.4
                  • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                  • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                  Entry version: 1

                  Date
                  Changes
                  Submitters
                  Reviewers
                  2015-06-12
                  Submitted
                  • (ID: V5OJFE3GCDVKSA62LSGPW5E6)
                  • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
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