BGC0000200 - 1 region(s) - antiSMASH results

Identified secondary metabolite regions using strictness 'relaxed'

BGC0000200 (uncultured bacterium)

Region	Type	From	To	Similarity Confidence	Most similar known cluster
Region 1	T2PKS	1	31,965	High	arixanthomycin A/arixanthomycin B/arixanthomycin C	PKS:Type II+saccharide:hybrid/tailoring

BGC0000200 - Region 1 - T2PKS

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Location: 1 - 31,965 nt. (total: 31,965 nt) Show pHMM detection rules used

Region on contig edge.

T2PKS: (t2ks and t2clf)

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

TTA codons

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Gene details

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Gene overview

MIBiG

Tailoring

MIBiG comparison

KnownClusterBlast

NRPS/PKS domains

Gene/CDS overview

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Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

External annotation

Name		MIBiG
Version		4.0alpha

Type		Subregion
Location		1 - 31,966
Label		BGC0000200

Tailoring functions

Oxidoreductases: dehydrogenase oxidoreductase oxygenase

arx10: monooxygenase FAD-binding

smcogs: SMCOG1050: monooxygenase FAD-binding

arx13: 3-hydroxyisobutyrate dehydrogenase

smcogs: SMCOG1100: 3-hydroxyisobutyrate dehydrogenase

arx21: short-chain dehydrogenase/reductase SDR

smcogs: SMCOG1001: short-chain dehydrogenase/reductase SDR

arx27: short-chain dehydrogenase/reductase SDR

smcogs: SMCOG1001: short-chain dehydrogenase/reductase SDR

arx30: monooxygenase FAD-binding

smcogs: SMCOG1050: monooxygenase FAD-binding

arx33: oxidoreductase

smcogs: SMCOG1083: oxidoreductase

arx4: short-chain dehydrogenase/reductase SDR

smcogs: SMCOG1001: short-chain dehydrogenase/reductase SDR

Transferases: glycosyltransferase methyltransferase

arx12: O-methyltransferase

smcogs: SMCOG1042: O-methyltransferase

arx2: methyltransferase

smcogs: SMCOG1089: methyltransferase

arx3: glycosyltransferase, MGT family

smcogs: SMCOG1062: glycosyltransferase, MGT family

arx34: O-methyltransferase

smcogs: SMCOG1042: O-methyltransferase

arx6: O-methyltransferase

smcogs: SMCOG1042: O-methyltransferase

arx9: glycosyltransferase, MGT family

smcogs: SMCOG1062: glycosyltransferase, MGT family

Hydrolases: hydrolase

arx5: asparagine synthase (glutamine-hydrolyzing)

smcogs: SMCOG1177: asparagine synthase (glutamine-hydrolyzing)

Lyases: cyclase dehydratase

arx1: NAD-dependent epimerase/dehydratase

smcogs: SMCOG1010: NAD-dependent epimerase/dehydratase

arx14: Polyketide synthesis cyclase

smcogs: SMCOG1225: Polyketide synthesis cyclase

arx19: cyclase/dehydrase

smcogs: SMCOG1128: cyclase/dehydrase

arx24: NAD-dependent epimerase/dehydratase

smcogs: SMCOG1010: NAD-dependent epimerase/dehydratase

Ligases: synthase

arx16: Beta-ketoacyl synthase

smcogs: SMCOG1022: Beta-ketoacyl synthase

arx17: Beta-ketoacyl synthase

smcogs: SMCOG1093: Beta-ketoacyl synthase

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000200.5	1.00	PKS, saccharide	arixanthomycin A, arixanthomycin B, arixanthomycin C	uncultured bacterium
BGC0000231.5	0.71	PKS	griseusin A, griseusin B	Streptomyces griseus
BGC0000272.3	0.67	PKS	spore pigment	Streptomyces collinus
BGC0001197.5	0.63	PKS	frankiamicin	Frankia sp. EAN1pec
BGC0001513.3	0.62	PKS	anthrabenzoxocinone	Actinobacteria bacterium
BGC0000234.5	0.59	PKS	jadomycin	Streptomyces venezuelae ATCC 10712
BGC0001366.5	0.57	PKS	BE-24566B, zunyimycin A	Streptomyces sp. FJS31-2
BGC0000215.5	0.57	PKS	curamycin	Streptomyces cyaneus
BGC0001723.5	0.56	PKS	oviedomycin	Streptomyces antibioticus
BGC0000275.4	0.56	PKS	tetracenomycin C	Streptomyces glaucescens

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000200.5	1.00	PKS, saccharide	arixanthomycin A, arixanthomycin B, arixanthomycin C	uncultured bacterium
BGC0000231.5	0.71	PKS	griseusin A, griseusin B	Streptomyces griseus
BGC0000272.3	0.67	PKS	spore pigment	Streptomyces collinus
BGC0001197.5	0.63	PKS	frankiamicin	Frankia sp. EAN1pec
BGC0001513.3	0.62	PKS	anthrabenzoxocinone	Actinobacteria bacterium
BGC0000234.5	0.59	PKS	jadomycin	Streptomyces venezuelae ATCC 10712
BGC0001366.5	0.57	PKS	BE-24566B, zunyimycin A	Streptomyces sp. FJS31-2
BGC0000215.5	0.57	PKS	curamycin	Streptomyces cyaneus
BGC0001723.5	0.56	PKS	oviedomycin	Streptomyces antibioticus
BGC0000275.4	0.56	PKS	tetracenomycin C	Streptomyces glaucescens

Similar known clusters from MIBiG 4.0

Detailed domain annotation

Selected features only

Show module domains

Type II PKS

Type II PKS gene cluster prediction details

Cluster section:: 0 to 31965
Starter unit(s):: malonamyl-CoA (Score: 526.0; E-value: 0)
Malonyl elongations:: 11|12 (Score: 702.6; E-value: 2.8e-214)
Product class(es):: pentangular polyphenol
Product molecular weight(s):: malonamyl-CoA_11: 942 Da
malonamyl-CoA_12: 985 Da

arx10: OXY (Score: 277.1; E-value: 6.9e-85)
arx12: MET (Score: 282.7; E-value: 9.1e-87)
arx14: CYC C4-C21/C2-C23|C2-C19 (Score: 174.1; E-value: 1.4e-54)
arx15: CYC C5-C18 (Score: 222.0; E-value: 4.4e-69)
arx16: KS (Score: 758.5; E-value: 3.8e-231)
arx17: CLF 11|12 (Score: 702.6; E-value: 2.8e-214)
arx18: ACP (Score: 108.7; E-value: 2.5e-34)
arx19: CYC C9-C14 (Score: 236.6; E-value: 2e-73)
arx2: MET (Score: 27.1; E-value: 5e-09)
arx21: KR C19 (Score: 426.4; E-value: 8.1e-131)
arx27: KR C11 (Score: 455.0; E-value: 1.3e-139)
arx3: GT (Score: 391.7; E-value: 1.1e-119)
arx30: OXY (Score: 309.4; E-value: 1.1e-94)
arx34: MET C13O|C17O (Score: 493.8; E-value: 4.8e-151)
arx4: KR (Score: 105.0; E-value: 1.2e-32)
arx5: AMID (Score: 693.2; E-value: 5.8e-211); AMID CAM34350.1_Lysolipin_malonamyl-CoA (Score: 526.0; E-value: 0.0)
arx6: MET C11O (Score: 520.8; E-value: 3.1e-159)
arx9: GT (Score: 435.0; E-value: 7.8e-133)