BGC0000208 - 1 region(s) - antiSMASH results

Identified secondary metabolite regions using strictness 'relaxed'

BGC0000208 (Amycolatopsis sulphurea)

Region	Type	From	To	Most similar known cluster		Similarity
Region 1	T2PKS	1	26,101	chlortetracycline	Polyketide	31%

BGC0000208 - Region 1 - T2PKS

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Location: 1 - 26,101 nt. (total: 26,101 nt) Show pHMM detection rules used

Region on contig edge.

T2PKS: (t2ks and t2clf)

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core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

TTA codons

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Gene details

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MIBiG

NRPS/PKS domains

MIBiG comparison

KnownClusterBlast

NRPS/PKS modules

External annotation

Name		MIBiG
Version		3.0

Type		Subregion
Location		1 - 26,102
Label		BGC0000208

Detailed domain annotation

Selected features only

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Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000208.1	0.83	Polyketide	chelocardin	Amycolatopsis sulphurea
BGC0000231.1	0.41	Polyketide	griseusin	Streptomyces griseus
BGC0000248.1	0.39	Polyketide	naphtocyclinone	Streptomyces arenae
BGC0000234.1	0.29	Polyketide	jadomycin	Streptomyces venezuelae ATCC 10712
BGC0000272.1	0.28	Polyketide	spore pigment	Streptomyces collinus
BGC0001444.1	0.28	Other	caboxamycin	Streptomyces sp. NTK 937
BGC0001723.1	0.26	Polyketide	oviedomycin	Streptomyces antibioticus
BGC0000215.1	0.25	Polyketide	curamycin	Streptomyces cyaneus
BGC0000836.1	0.23	Other	APE Ec	Escherichia coli CFT073
BGC0001831.1	0.23	Polyketide	alkylpyrone-407, alkylpyrone-393	Myxococcus xanthus DK 1622

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000208.1	0.94	Polyketide	chelocardin	Amycolatopsis sulphurea
BGC0000231.1	0.72	Polyketide	griseusin	Streptomyces griseus
BGC0000248.1	0.71	Polyketide	naphtocyclinone	Streptomyces arenae
BGC0000234.1	0.63	Polyketide	jadomycin	Streptomyces venezuelae ATCC 10712
BGC0000272.1	0.61	Polyketide	spore pigment	Streptomyces collinus
BGC0001444.1	0.61	Other	caboxamycin	Streptomyces sp. NTK 937
BGC0001723.1	0.60	Polyketide	oviedomycin	Streptomyces antibioticus
BGC0000215.1	0.59	Polyketide	curamycin	Streptomyces cyaneus
BGC0000836.1	0.57	Other	APE Ec	Escherichia coli CFT073
BGC0001831.1	0.56	Polyketide	alkylpyrone-407, alkylpyrone-393	Myxococcus xanthus DK 1622

Similar known gene clusters

Module view

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NRPS/PKS products

NRPS/PKS monomers

Type II PKS

Predicted core structure(s)

For candidate cluster 1, location 0 - 26101:

Rough prediction of core scaffold based on assumed PKS linker matching; tailoring reactions not taken into account

Polymer prediction:: (mal)
Non-colinear ordering:: chdK + chdS

Direct lookup in NORINE database: strict or relaxed

Link to NORINE database query form

NRPS/PKS monomer predictions

chdL-chdOIII

Search NORINE for peptide: strict or relaxed

AMP-binding (35..435): X

NRPSPredictor2: hydrophilic

SVM prediction details:

Predicted physicochemical class:: hydrophilic
Large clusters prediction:: N/A
Small clusters prediction:: N/A
Single AA prediction:: N/A

Stachelhaus prediction details:

Stachelhaus sequence:: h-myLGGpsK
Nearest Stachelhaus code:: leu
Stachelhaus code match:: 40% (weak)

Type II PKS gene cluster prediction details

Cluster section:: 0 to 26101
Starter unit(s):: malonamyl-CoA (Score: 654.0; E-value: 0)
Malonyl elongations:: 8|9 (Score: 690.7; E-value: 1.2e-210)
Product class(es):: anthracycline
aureolic acid
tetracycline
Product molecular weight(s):: malonamyl-CoA_8: 586.61 Da
malonamyl-CoA_9: 628.64 Da

chdGIV: GT (Score: 324.7; E-value: 2.5e-99)
chdK: CLF 8|9 (Score: 690.7; E-value: 1.2e-210)
chdL-chdOIII: LIG (Score: 671.6; E-value: 1.4e-204); LIG ELQ83297.1_Oxytetracycline_malonamyl-CoA (Score: 654.0; E-value: 0.0)
chdMI: MET C6|C8 (Score: 582.3; E-value: 5.8e-178)
chdMII: MET C10 (Score: 648.4; E-value: 4.6e-198)
chdN: AMIN (Score: 567.2; E-value: 3.1e-173)
chdOI: OXY (Score: 217.7; E-value: 7.4e-67)
chdOII-chdY: OXY (Score: 428.8; E-value: 6.9e-131); CYC C5-C14/C3-C16 (Score: 417.0; E-value: 6.3e-128)
chdP: KS (Score: 751.1; E-value: 6.7e-229)
chdQI: CYC C7-C12 (Score: 285.5; E-value: 9.4e-88)
chdQII: CYC C7-C12 (Score: 450.1; E-value: 7.2e-138)
chdS: ACP (Score: 117.4; E-value: 4.8e-37)
chdT: KR C9 (Score: 463.0; E-value: 5.8e-142)
chdX: CYC C1-C18|C2-C19 (Score: 228.0; E-value: 7.7e-71)