BGC0000397: nostocyclopeptide A2 biosynthetic gene cluster from Nostoc sp. ATCC 53789
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Location: 1 - 34,328 nt. (total: 34,328 nt).
This entry is originally from NCBI GenBank AY167420.1.

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core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
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General
Compounds
Genes
Biosynthesis
History
NRPS/PKS domains
KnownClusterBlast
General information about the BGC
MIBiG accession BGC0000397
Short description nostocyclopeptide A2 biosynthetic gene cluster from Nostoc sp. ATCC 53789
Status Quality: questionable
The quality level of this entry.

Status: active
The status of this entry.

Completeness: unknown
Whether the entry covers everything needed for the pathway producing the compound(s)
Biosynthetic class(es)
  • NRPS (Type I)
Loci
AY167420.1
via
Compounds
  • nostocyclopeptide A2
Species Nostoc sp. ATCC 53789 [taxonomy]
References
Chemical products information
nostocyclopeptide A2 Evidence:
Copy SMILES
C40H54N8O9
Chemical database entries
NPAtlas
List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Extra
  • AAO23328.1
  • ncpE
1175 - 1996 (-) NcpE
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    • AAO23329.1
    • ncpD
    2036 - 3142 (-) NcpD
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      • AAO23330.1
      3191 - 3988 (-) unknown
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        • AAO23331.1
        4090 - 5694 (-) penicillin-binding protein-like protein
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          • AAO23332.1
          • ncpC
          5793 - 7811 (-) NcpC
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            • AAO23333.1
            • ncpA
            8496 - 19703 (+) NcpA
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              • AAO23334.1
              • ncpB
              19700 - 34111 (+) NcpB
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                Biosynthesis information

                Biosynthetic modules

                Name
                Unk01
                Type
                nrps-type1
                Genes
                ncpA
                Substrates
                tyrosine, leucine, phenylalanine, alanine (evidence: ATP-PPi exchange assay [1])
                Integrated Monomers
                Domains
                adenylation
                Name
                Unk02
                Type
                nrps-type1
                Genes
                ncpA
                Substrates
                glycine (evidence: Structure-based inference [1])
                Integrated Monomers
                Domains
                adenylation
                Name
                Unk03
                Type
                nrps-type1
                Genes
                ncpA
                Substrates
                glutamine (evidence: Structure-based inference [1])
                Integrated Monomers
                Domains
                adenylation
                Name
                Unk04
                Type
                nrps-type1
                Genes
                ncpB
                Substrates
                isoleucine, methionine (evidence: ATP-PPi exchange assay [1])
                Integrated Monomers
                Domains
                adenylation
                Name
                Unk05
                Type
                nrps-type1
                Genes
                ncpB
                Substrates
                serine (evidence: Structure-based inference [1])
                Integrated Monomers
                Domains
                adenylation
                Name
                Unk06
                Type
                nrps-type1
                Genes
                ncpB
                Substrates
                4S-methylproline (evidence: Structure-based inference [1])
                Integrated Monomers
                Domains
                adenylation
                Name
                Unk07
                Type
                nrps-type1
                Genes
                ncpB
                Substrates
                leucine, phenylalanine (evidence: Structure-based inference [1])
                Integrated Monomers
                Domains
                adenylation
                Annotation changelog

                Entry version: 4

                Date
                Changes
                Submitters
                Reviewers
                Update chemical activity to schema version 2.11
                • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                Entry version: 3

                Date
                Changes
                Submitters
                Reviewers
                Updated bioactivity data
                • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                Added NRP substrate specificities
                • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                Entry version: 2

                Date
                Changes
                Submitters
                Reviewers
                Migrated from v1.4
                • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                Updated compound(s) information (NPAtlas curation)
                • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                Entry version: 1

                Date
                Changes
                Submitters
                Reviewers
                Submitted
                • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                Detailed domain annotation
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