BGC0000397 - 1 region(s) - antiSMASH results

Identified secondary metabolite regions using strictness 'relaxed'

BGC0000397 (Nostoc sp. ATCC 53789)

Region	Type	From	To	Most similar known cluster		Similarity
Region 1	NRPS	1	34,328	nostopeptolide A2	Polyketide + NRP:Cyclic depsipeptide	87%

BGC0000397 - Region 1 - NRPS

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Location: 1 - 34,328 nt. (total: 34,328 nt) Show pHMM detection rules used

Region on contig edge.

NRPS: cds(Condensation and (AMP-binding or A-OX))

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core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

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Gene details

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MIBiG

NRPS/PKS domains

MIBiG comparison

KnownClusterBlast

NRPS/PKS modules

External annotation

Name		MIBiG
Version		3.0

Type		Subregion
Location		1 - 34,329
Label		BGC0000397

Detailed domain annotation

Selected features only

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Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000397.1	0.95	NRP	nostocyclopeptide A2	Nostoc sp. ATCC 53789
BGC0000389.1	0.41	NRP	massetolide A	Pseudomonas fluorescens SS101
BGC0002071.1	0.40	NRP	Virginiafactin	Pseudomonas sp. QS1027
BGC0001844.1	0.34	NRP	holrhizin	Paraburkholderia rhizoxinica HKI 454
BGC0001131.1	0.33	NRP	ambactin	Xenorhabdus miraniensis
BGC0000331.1	0.32	NRP	cyanopeptin	Planktothrix agardhii NIVA-CYA 116
BGC0001758.1	0.32	NRP	rhizomide A, rhizomide B, rhizomide C	Paraburkholderia rhizoxinica HKI 454
BGC0001135.1	0.32	NRP	bicornutin A1, bicornutin A2	Xenorhabdus budapestensis
BGC0001399.1	0.31	NRP	fellutamide B	Aspergillus nidulans FGSC A4
BGC0001833.1	0.30	NRP	icosalide A, icosalide B	Burkholderia gladioli

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000397.1	0.98	NRP	nostocyclopeptide A2	Nostoc sp. ATCC 53789
BGC0000389.1	0.73	NRP	massetolide A	Pseudomonas fluorescens SS101
BGC0002071.1	0.72	NRP	Virginiafactin	Pseudomonas sp. QS1027
BGC0001844.1	0.67	NRP	holrhizin	Paraburkholderia rhizoxinica HKI 454
BGC0001131.1	0.66	NRP	ambactin	Xenorhabdus miraniensis
BGC0000331.1	0.66	NRP	cyanopeptin	Planktothrix agardhii NIVA-CYA 116
BGC0001758.1	0.65	NRP	rhizomide A, rhizomide B, rhizomide C	Paraburkholderia rhizoxinica HKI 454
BGC0001135.1	0.65	NRP	bicornutin A1, bicornutin A2	Xenorhabdus budapestensis
BGC0001399.1	0.64	NRP	fellutamide B	Aspergillus nidulans FGSC A4
BGC0001833.1	0.64	NRP	icosalide A, icosalide B	Burkholderia gladioli

Similar known gene clusters

Module view

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NRPS/PKS products

NRPS/PKS monomers

Predicted core structure(s)

For candidate cluster 1, location 0 - 34328:

Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:: (tyr - gly - D-gln) + (ile - ser - pro - phe)

Direct lookup in NORINE database: strict or relaxed

Link to NORINE database query form

NRPS/PKS monomer predictions

ncpA

Search NORINE for peptide: strict or relaxed

AMP-binding (535..936): tyr

NRPSPredictor2: tyr

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aromatic
Large clusters prediction:: phe, trp, phg, tyr, bht
Small clusters prediction:: tyr, bht
Single AA prediction:: tyr

Stachelhaus prediction details:

Stachelhaus sequence:: DASTVAAVCK
Nearest Stachelhaus code:: tyr
Stachelhaus code match:: 100% (strong)

AMP-binding (1596..1997): gly

NRPSPredictor2: gly

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic
Large clusters prediction:: gly, ala, val, leu, ile, abu, iva
Small clusters prediction:: gly, ala
Single AA prediction:: gly

Stachelhaus prediction details:

Stachelhaus sequence:: DILQLGLIWK
Nearest Stachelhaus code:: gly
Stachelhaus code match:: 100% (strong)

AMP-binding (2671..3080): gln

NRPSPredictor2: gln

SVM prediction details:

Predicted physicochemical class:: hydrophilic
Large clusters prediction:: asp, asn, glu, gln, aad
Small clusters prediction:: glu, gln
Single AA prediction:: gln

Stachelhaus prediction details:

Stachelhaus sequence:: DAWQFGLIDK
Nearest Stachelhaus code:: gln
Stachelhaus code match:: 100% (strong)

ncpB

Search NORINE for peptide: strict or relaxed

AMP-binding (486..913): ile

NRPSPredictor2: ile

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic
Large clusters prediction:: gly, ala, val, leu, ile, abu, iva
Small clusters prediction:: val, leu, ile, abu, iva
Single AA prediction:: ile

Stachelhaus prediction details:

Stachelhaus sequence:: DAFFLGVTFK
Nearest Stachelhaus code:: ile
Stachelhaus code match:: 100% (strong)

AMP-binding (1587..2010): ser

NRPSPredictor2: ser

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic
Large clusters prediction:: ser, thr, dhpg, hpg
Small clusters prediction:: ser
Single AA prediction:: ser

Stachelhaus prediction details:

Stachelhaus sequence:: DVWHISLIDK
Nearest Stachelhaus code:: ser
Stachelhaus code match:: 100% (strong)

AMP-binding (2674..3142): pro

NRPSPredictor2: pro

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic
Large clusters prediction:: pro, pip
Small clusters prediction:: pro
Single AA prediction:: pro

Stachelhaus prediction details:

Stachelhaus sequence:: DVQFIAHVaK
Nearest Stachelhaus code:: pro
Stachelhaus code match:: 90% (moderate)

AMP-binding (3804..4217): phe

NRPSPredictor2: phe

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aromatic
Large clusters prediction:: phe, trp, phg, tyr, bht
Small clusters prediction:: phe, trp
Single AA prediction:: N/A

Stachelhaus prediction details:

Stachelhaus sequence:: DAWTIgGVCK
Nearest Stachelhaus code:: phe
Stachelhaus code match:: 90% (moderate)