BGC0000446: tilivalline biosynthetic gene cluster from Klebsiella oxytoca
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Location: 1 - 25,846 nt. (total: 25,846 nt).
This entry is originally from NCBI GenBank HG425356.1.

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core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
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Gene details
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General
Compounds
Genes
Biosynthesis
History
NRPS/PKS domains
KnownClusterBlast
General information about the BGC
MIBiG accession BGC0000446
Short description tilivalline biosynthetic gene cluster from Klebsiella oxytoca
Status Quality: questionable
The quality level of this entry.

Status: active
The status of this entry.

Completeness: complete
Whether the entry covers everything needed for the pathway producing the compound(s)
Biosynthetic class(es)
  • NRPS (Type I)
Loci
HG425356.1
via Gene expression correlated with compound production
Compounds
  • tilivalline
  • 9-deoxy tilivalline
  • dihydroxy tilivalline
  • dehydro tilivalline
  • dihydroxy-dehydro tilivalline
Species Klebsiella oxytoca [taxonomy]
References
Chemical products information
tilivalline Evidence: Mass spectrometry
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C20H19N3O2
Chemical database entries
PubCHEM
9-deoxy tilivalline Evidence: Mass spectrometry
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C20H19N3O1
dihydroxy tilivalline Evidence: Mass spectrometry
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C20H19N3O3
dehydro tilivalline Evidence: Mass spectrometry
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C20H17N3O2
dihydroxy-dehydro tilivalline Evidence: Mass spectrometry
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C20H17N3O3
List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Extra
  • CDG76945.1
 405 - 1322 (+) Nitrogen assimilation regulatory protein Nac
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    • CDG76946.1
    		 1429 - 2379 (+) Alkanesulfonate utilization operon LysR-family regulator CbI
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      • CDG76947.1
      		 2458 - 3381 (+) L,D-transpeptidase ErfK
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        • pseudo3498_4106
        		 3499 - 4106 (-) Glutathione S-transferase, unnamed subgroup 2
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          • CDG76949.1
          		 4283 - 5188 (+) Glycine cleavage system transcriptional activator GcvA
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            • CDG76950.1
            • mfsX
            		 5613 - 6845 (+) permease of the major facilitator superfamily protein
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              • CDG76951.1
              • uvrX
              		 6850 - 9072 (+) Excinuclease ABC subunit A paralog of unknown function
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                • CDG76952.1
                • hmoX
                		 9195 - 10712 (-) 4-hydroxyphenylacetate 3-monooxygenase
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                  • CDG76953.1
                  • adsX
                  		 10751 - 12700 (-) 2-Amino-2-deoxy-isochorismate synthase
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                    • CDG76954.1
                    • icmX
                    		 12730 - 13362 (-) Isochorismatase of siderophore biosynthesis
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                      • CDG76955.1
                      • dhbX
                      		 13381 - 14166 (-) 2,3-dihydro-2,3-dihydroxybenzoate dehydrogenase
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                        • CDG76956.1
                        • aroX
                        		 14156 - 15325 (-) 2-keto-3-deoxy-D-arabino-heptulosonate-7- phosphate synthase II
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                          • CDG76957.1
                          • npsA
                          		 15783 - 17303 (+) non-ribosomal peptide synthetase
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                            • CDG76958.1
                            		 17306 - 17536 (+) PCP domain
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                              • CDG76959.1
                              • npsB
                              		 17602 - 21972 (+) non-ribosomal peptide synthetase, terminal component
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                                • CDG76960.1
                                		 22516 - 23013 (+) transcriptional regulator, MarR family
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                                  • CDG76961.1
                                  		 24005 - 24184 (+) hypothetical protein
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                                    • CDG76962.1
                                    		 24193 - 25644 (+) Putative inner membrane protein
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                                      Biosynthesis information

                                      Biosynthetic modules

                                      Name
                                      0
                                      Type
                                      nrps-type1
                                      Genes
                                      npsA
                                      Substrates
                                      2,3-dihydroxybenzoic acid (evidence: Feeding study)
                                      Integrated Monomers
                                      Domains
                                      adenylation
                                      Name
                                      1
                                      Type
                                      nrps-type1
                                      Genes
                                      npsB
                                      Substrates
                                      proline (evidence: Feeding study)
                                      Integrated Monomers
                                      Domains
                                      condensation (LCL), adenylation
                                      Annotation changelog

                                      Entry version: 4

                                      Date
                                      Changes
                                      Submitters
                                      Reviewers
                                      2022-10-07
                                      Update chemical activity to schema version 2.11
                                      • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                      • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                                      Entry version: 3

                                      Date
                                      Changes
                                      Submitters
                                      Reviewers
                                      2022-09-15
                                      Corrected NRP module activity
                                      • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                      • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                      2022-09-15
                                      Removed annotation for duplicate of pseudogene
                                      • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                      • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                      2022-09-15
                                      Updated bioactivity data
                                      • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                      • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                      2022-09-15
                                      Updated NRP substrate specificities
                                      • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                      • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                                      Entry version: 2

                                      Date
                                      Changes
                                      Submitters
                                      Reviewers
                                      2019-10-16
                                      Migrated from v1.4
                                      • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                      • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                                      Entry version: 1

                                      Date
                                      Changes
                                      Submitters
                                      Reviewers
                                      2015-06-12
                                      Submitted
                                      • (ID: O7W664GPYKX3NUS2LLMP5XCG)
                                      • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                      Detailed domain annotation
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