BGC0001000 - 1 region(s) - antiSMASH results

Identified secondary metabolite regions using strictness 'relaxed'

BGC0001000 (Lyngbya majuscula)

Region	Type	From	To	Most similar known cluster		Similarity
Region 1	NRPS,T1PKS	1	41,964	nocuolin A	Other	18%

BGC0001000 - Region 1 - NRPS,T1PKS

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Location: 1 - 41,964 nt. (total: 41,964 nt) Show pHMM detection rules used

Region on contig edge.

NRPS: cds(Condensation and (AMP-binding or A-OX))
T1PKS: cds(PKS_AT and (PKS_KS or ene_KS or mod_KS or hyb_KS or itr_KS or tra_KS))

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core biosynthetic genes

additional biosynthetic genes

transport-related genes

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Gene details

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MIBiG

NRPS/PKS domains

MIBiG comparison

KnownClusterBlast

NRPS/PKS modules

External annotation

Name		MIBiG
Version		3.0

Type		Subregion
Location		1 - 41,965
Label		BGC0001000

Detailed domain annotation

Selected features only

Show module domains

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001000.1	1.36	NRP, Polyketide	hectochlorin	Lyngbya majuscula
BGC0001068.1	0.53	Terpene, Polyketide	pyripyropene A	unidentified unclassified sequences.
BGC0001163.1	0.49	Polyketide	1-heptadecene	Moorea producens 3L
BGC0001162.1	0.49	Polyketide	1-heptadecene	Moorea producens JHB
BGC0001161.1	0.49	Polyketide	1-heptadecene	Moorea bouillonii PNG
BGC0001909.1	0.46	Polyketide	strobilurin	Strobilurus tenacellus
BGC0001164.1	0.45	Polyketide	1-heptadecene	Cyanothece sp. PCC 7822
BGC0001160.1	0.43	Polyketide	1-nonadecene, (14Z)-1,14-nonadecadiene	Synechococcus sp. PCC 7002
BGC0000979.1	0.43	NRP, Polyketide	cylindrospermopsin	Aphanizomenon sp. 10E9
BGC0000980.1	0.43	NRP, Polyketide	cylindrospermopsin	Aphanizomenon sp. 22D11

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001000.1	0.94	NRP, Polyketide	hectochlorin	Lyngbya majuscula
BGC0001068.1	0.62	Terpene, Polyketide	pyripyropene A	unidentified unclassified sequences.
BGC0001280.1	0.59	Polyketide	betaenone C, betaenone A	Phoma betae
BGC0001264.1	0.59	Polyketide	betaenone A, betaenone B, betaenone C	Phoma betae
BGC0001163.1	0.59	Polyketide	1-heptadecene	Moorea producens 3L
BGC0001162.1	0.59	Polyketide	1-heptadecene	Moorea producens JHB
BGC0001161.1	0.59	Polyketide	1-heptadecene	Moorea bouillonii PNG
BGC0001831.1	0.57	Polyketide	alkylpyrone-407, alkylpyrone-393	Myxococcus xanthus DK 1622
BGC0001104.1	0.57	NRP, Polyketide	myxovirescin A1	Myxococcus xanthus DK 1622
BGC0001629.1	0.57	NRP	Jessenipeptin	Pseudomonas sp. QS1027

Similar known gene clusters

Module view

Legend

NRPS/PKS products

NRPS/PKS monomers

Predicted core structure(s)

For candidate cluster 1, location 0 - 41964:

Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:: (Me-ohmal) + (cys) + (cys)

Direct lookup in NORINE database: strict or relaxed

Link to NORINE database query form

NRPS/PKS monomer predictions

AAY42393.1

CAL_domain (167..488): pk

minowa: NH2

Prediction, score:

NH2: 149.6
Acetyl-CoA: 58.1
fatty_acid: 37.5
AHBA: 19.1
shikimic_acid: 0.0

AAY42396.1

PKS_AT (529..832): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 100.0%; inactive: 95.8%; 2-Rhyd-Malonyl-CoA: 54.2%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 197.9
inactive: 175.4
Methoxymalonyl-CoA: 65.2
Methylmalonyl-CoA: 61.3
Isobutyryl-CoA: 38.4
Propionyl-CoA: 32.8
Ethylmalonyl-CoA: 24.2
2-Methylbutyryl-CoA: 19.1
CHC-CoA: 16.4
Acetyl-CoA: 16.4
Benzoyl-CoA: 15.5
trans-1,2-CPDA: 13.6
3-Methylbutyryl-CoA: 10.6
fatty_acid: 0.0

AAY42397.1

Search NORINE for peptide: strict or relaxed

CAL_domain (850..1267): pk

minowa: fatty_acid

Prediction, score:

fatty_acid: 51.8
NH2: 10.8
Acetyl-CoA: 8.5
shikimic_acid: 0.0
AHBA: -2.8

AMP-binding (2502..2902): cys

NRPSPredictor2: cys

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic
Large clusters prediction:: cys
Small clusters prediction:: cys
Single AA prediction:: cys

Stachelhaus prediction details:

Stachelhaus sequence:: DLYNLSLIWK
Nearest Stachelhaus code:: cys
Stachelhaus code match:: 100% (strong)

AAY42398.1

Search NORINE for peptide: strict or relaxed

AMP-binding (542..926): X

NRPSPredictor2: (unknown)

SVM prediction details:

NOTE: outside applicability domain

Predicted physicochemical class:: hydrophilic
Large clusters prediction:: N/A
Small clusters prediction:: N/A
Single AA prediction:: N/A

Stachelhaus prediction details:

Stachelhaus sequence:: eswNLSageK
Nearest Stachelhaus code:: cys
Stachelhaus code match:: 40% (weak)

CAL_domain (1142..1560): pk

minowa: fatty_acid

Prediction, score:

fatty_acid: 51.8
NH2: 10.8
Acetyl-CoA: 8.5
shikimic_acid: 0.0
AHBA: -2.8

AMP-binding (2796..3198): cys

NRPSPredictor2: cys

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic
Large clusters prediction:: cys
Small clusters prediction:: cys
Single AA prediction:: cys

Stachelhaus prediction details:

Stachelhaus sequence:: DLYNLSLIWK
Nearest Stachelhaus code:: cys
Stachelhaus code match:: 100% (strong)