BGC0001033: paenilamicin biosynthetic gene cluster from Paenibacillus larvae subsp. larvae DSM 25430
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Location: 1,729,923 - 1,788,675 nt. (total: 58,753 nt).
This entry is originally from NCBI GenBank CP003355.1.

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core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
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General
Compounds
Genes
Biosynthesis
History
NRPS/PKS domains
KnownClusterBlast
General information about the BGC
MIBiG accession BGC0001033
Short description paenilamicin biosynthetic gene cluster from Paenibacillus larvae subsp. larvae DSM 25430
Status Quality: questionable
The quality level of this entry.

Status: active
The status of this entry.

Completeness: unknown
Whether the entry covers everything needed for the pathway producing the compound(s)
Biosynthetic class(es)
  • NRPS (Type I)
  • PKS (Unknown)
Loci
CP003355.1
1729923 - 1788675
via
Compounds
  • paenilamicin
  • paenilamicin A2
  • paenilamicin B1
  • paenilamicin B2
Species Paenibacillus larvae subsp. larvae DSM 25430 [taxonomy]
References
Chemical products information
paenilamicin Evidence:
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C43H88N14O13
paenilamicin A2 Evidence:
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C42H86N14O13
paenilamicin B1 Evidence:
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C43H88N16O13
paenilamicin B2 Evidence:
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C42H86N16O13
List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Extra
  • ERIC2_c18040
  • AHD05614.1
 1729923 - 1737689 (+) putative non-ribosomal peptide ligase/ polyketide synthase hybrid
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    • ERIC2_c18050
    • AHD05615.1
    		 1737728 - 1746766 (+) putative non-ribosomal peptide ligase/ polyketide synthase hybrid
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      • ERIC2_c18060
      • AHD05616.1
      		 1746763 - 1752078 (+) putative non-ribosomal peptide ligase domain protein
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        • ERIC2_c18070
        • AHD05617.1
        		 1752098 - 1756096 (+) putative non-ribosomal peptide ligase domain protein
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          • ERIC2_c18080
          • AHD05618.1
          		 1756143 - 1759442 (+) putative non-ribosomal peptide ligase domain protein
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            • ERIC2_c18090
            • AHD05619.1
            		 1759625 - 1764208 (+) putative polyketide synthase subunit
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              • ERIC2_c18100
              • AHD05620.1
              		 1764209 - 1769791 (+) putative polyketide synthase subunit
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                • ERIC2_c18110
                • AHD05621.1
                		 1769806 - 1778028 (+) non-ribosomal peptide ligase domain protein
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                  • ERIC2_c18120
                  • AHD05622.1
                  		 1778104 - 1778985 (+) hypothetical protein
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                    • ERIC2_c18130
                    • AHD05623.1
                    		 1778996 - 1782103 (+) cyclic peptide transporter
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                      • ERIC2_c18140
                      • AHD05624.1
                      		 1782135 - 1782992 (+) 3-hydroxybutyryl-CoA dehydrogenase
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                        • ERIC2_c18150
                        • AHD05625.1
                        		 1783021 - 1783290 (+) phosphopantetheine-binding protein
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                          • ERIC2_c18160
                          • AHD05626.1
                          • nusG1
                          		 1783305 - 1783835 (-) transcription antitermination protein NusG
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                            • ERIC2_c18170
                            • AHD05627.1
                            		 1784182 - 1788675 (+) putative non-ribosomal peptide ligase domain protein
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                              Biosynthesis information

                              Biosynthetic modules

                              Name
                              Unk01
                              Type
                              nrps-type1
                              Genes
                              ERIC2_c18040
                              Substrates
                              lysine, arginine (evidence: Structure-based inference, Mass spectrometry)
                              Integrated Monomers
                              Domains
                              adenylation
                              Name
                              Unk02
                              Type
                              nrps-type1
                              Genes
                              ERIC2_c18050
                              Substrates
                              D-alanine (evidence: Structure-based inference [1], [2])
                              Integrated Monomers
                              Domains
                              adenylation
                              Name
                              Unk03
                              Type
                              nrps-type1
                              Genes
                              ERIC2_c18060
                              Substrates
                              2,3-diaminopropionic acid (evidence: Structure-based inference [1], [2])
                              Integrated Monomers
                              Domains
                              adenylation
                              Name
                              Unk04
                              Type
                              nrps-type1
                              Genes
                              ERIC2_c18070
                              Substrates
                              lysine, ornithine (evidence: Structure-based inference, Mass spectrometry)
                              Integrated Monomers
                              Domains
                              adenylation
                              Name
                              Unk05
                              Type
                              nrps-type1
                              Genes
                              ERIC2_c18080
                              Substrates
                              serine (evidence: Structure-based inference [1], [2])
                              Integrated Monomers
                              Domains
                              adenylation
                              Name
                              Unk06
                              Type
                              nrps-type1
                              Genes
                              ERIC2_c18110
                              Substrates
                              Integrated Monomers
                              Domains
                              adenylation
                              Name
                              Unk07
                              Type
                              nrps-type1
                              Genes
                              ERIC2_c18110
                              Substrates
                              2,3-diaminopropionic acid (evidence: Structure-based inference [1], [2])
                              Integrated Monomers
                              Domains
                              adenylation
                              Name
                              Unk08
                              Type
                              nrps-type1
                              Genes
                              ERIC2_c18110
                              Substrates
                              glycine (evidence: Structure-based inference [1], [2])
                              Integrated Monomers
                              Domains
                              adenylation
                              Name
                              Unk09
                              Type
                              nrps-type1
                              Genes
                              ERIC2_c18170
                              Substrates
                              asparagine (evidence: Sequence-based prediction, Homology)
                              Integrated Monomers
                              Domains
                              adenylation
                              Annotation changelog

                              Entry version: 4

                              Date
                              Changes
                              Submitters
                              Reviewers
                              2022-10-07
                              Update chemical activity to schema version 2.11
                              • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                              • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                              Entry version: 3

                              Date
                              Changes
                              Submitters
                              Reviewers
                              2022-09-15
                              Add new compound structure (SMILES) for paenilamicin
                              • (ID: 5UL74VURKJ25VSPPPO3H2NYB)
                              • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                              2022-09-15
                              Add new compound: paenilamicin A2
                              • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                              • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                              2022-09-15
                              Add new compound: paenilamicin B1
                              • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                              • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                              2022-09-15
                              Add new compound: paenilamicin B2
                              • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                              • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                              2022-09-15
                              Fixed incorrect publication
                              • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                              • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                              2022-09-15
                              Updated bioactivity data
                              • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                              • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                              2022-09-15
                              Added NRP substrate specificities
                              • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                              • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                              Entry version: 2

                              Date
                              Changes
                              Submitters
                              Reviewers
                              2019-10-16
                              Migrated from v1.4
                              • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                              • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                              Entry version: 1

                              Date
                              Changes
                              Submitters
                              Reviewers
                              2015-06-12
                              Submitted
                              • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                              • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                              Detailed domain annotation
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