BGC0001062 - 1 region(s) - antiSMASH results

Identified secondary metabolite regions using strictness 'relaxed'

BGC0001062 (Micromonospora echinospora subsp. challisensis)

Region	Type	From	To	Most similar known cluster		Similarity
Region 1	T2PKS,PKS-like,T1PKS	1	39,835	WS79089A / hexaricin B / hexaricin C	Polyketide	45%

BGC0001062 - Region 1 - PKS-like,T1PKS,T2PKS

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Location: 1 - 39,835 nt. (total: 39,835 nt) Show pHMM detection rules used

Region on contig edge.

T2PKS: (t2ks and t2clf)
PKS-like: (t2pks2 or ksIII)
T1PKS: cds(PKS_AT and (PKS_KS or ene_KS or mod_KS or hyb_KS or itr_KS or tra_KS))

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core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

TTA codons

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Gene details

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MIBiG

NRPS/PKS domains

MIBiG comparison

KnownClusterBlast

NRPS/PKS modules

External annotation

Name		MIBiG
Version		3.0

Type		Subregion
Location		1 - 39,836
Label		BGC0001062

Detailed domain annotation

Selected features only

Show module domains

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001062.1	1.90	Polyketide	TLN-05220	Micromonospora echinospora subsp. challisensis
BGC0000248.1	1.26	Polyketide	naphtocyclinone	Streptomyces arenae
BGC0000228.1	1.00	Polyketide	granaticin	Streptomyces violaceoruber
BGC0000041.1	1.00	Polyketide	oronofacic acid	Pseudomonas syringae
BGC0001444.1	0.96	Other	caboxamycin	Streptomyces sp. NTK 937
BGC0000215.1	0.94	Polyketide	curamycin	Streptomyces cyaneus
BGC0000234.1	0.93	Polyketide	jadomycin	Streptomyces venezuelae ATCC 10712
BGC0000231.1	0.93	Polyketide	griseusin	Streptomyces griseus
BGC0000885.1	0.85	Other	4-hydroxy-3-nitrosobenzamide	Streptomyces murayamaensis
BGC0001197.1	0.85	Polyketide	frankiamicin	Frankia sp. EAN1pec

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001062.1	0.87	Polyketide	TLN-05220	Micromonospora echinospora subsp. challisensis
BGC0000248.1	0.73	Polyketide	naphtocyclinone	Streptomyces arenae
BGC0000041.1	0.67	Polyketide	oronofacic acid	Pseudomonas syringae
BGC0000228.1	0.66	Polyketide	granaticin	Streptomyces violaceoruber
BGC0001444.1	0.65	Other	caboxamycin	Streptomyces sp. NTK 937
BGC0000215.1	0.65	Polyketide	curamycin	Streptomyces cyaneus
BGC0000234.1	0.65	Polyketide	jadomycin	Streptomyces venezuelae ATCC 10712
BGC0000231.1	0.65	Polyketide	griseusin	Streptomyces griseus
BGC0001197.1	0.62	Polyketide	frankiamicin	Frankia sp. EAN1pec
BGC0000885.1	0.62	Other	4-hydroxy-3-nitrosobenzamide	Streptomyces murayamaensis

Similar known gene clusters

Module view

Legend

NRPS/PKS products

NRPS/PKS monomers

Type II PKS

Predicted core structure(s)

For candidate cluster 1, location 0 - 39835:

Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:: (Me-mal - Me-redmal)

Direct lookup in NORINE database: strict or relaxed

For candidate cluster 2, location 4220 - 39835:

Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:: (Me-mal - Me-redmal)

Direct lookup in NORINE database: strict or relaxed

For candidate cluster 3, location 10698 - 39835:

Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:: (Me-mal - Me-redmal)

Direct lookup in NORINE database: strict or relaxed

Link to NORINE database query form

NRPS/PKS monomer predictions

ADB23379.1

PKS_AT (294..583): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 66.7%; inactive: 54.2%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 45.5
Methylmalonyl-CoA: 25.8
Methoxymalonyl-CoA: 23.3
Propionyl-CoA: 21.1
CHC-CoA: 13.8
2-Methylbutyryl-CoA: 13.4
fatty_acid: 12.5
Ethylmalonyl-CoA: 12.0
inactive: 11.7
Isobutyryl-CoA: 6.0
trans-1,2-CPDA: 0.0
Benzoyl-CoA: 0.0
Acetyl-CoA: 0.0
3-Methylbutyryl-CoA: 0.0

ADB23403.1

PKS_AT (88..382): mmal

ATSignature: Methylmalonyl-CoA

Top 3 matches:: Methylmalonyl-CoA: 95.8%; Methoxymalonyl-CoA: 91.7%; Malonyl-CoA: 83.3%

minowa: Methylmalonyl-CoA

Prediction, score:

Methylmalonyl-CoA: 207.6
Ethylmalonyl-CoA: 194.2
Methoxymalonyl-CoA: 163.9
2-Methylbutyryl-CoA: 133.2
trans-1,2-CPDA: 132.2
Malonyl-CoA: 105.4
Isobutyryl-CoA: 101.2
Propionyl-CoA: 90.3
CHC-CoA: 89.4
Benzoyl-CoA: 65.5
3-Methylbutyryl-CoA: 44.5
Acetyl-CoA: 36.9
inactive: 19.5
fatty_acid: 16.9

PKS_AT (1109..1404): mmal

ATSignature: Methylmalonyl-CoA

Top 3 matches:: Methylmalonyl-CoA: 100.0%; Methoxymalonyl-CoA: 91.7%; Ethylmalonyl-CoA: 87.5%

minowa: Methylmalonyl-CoA

Prediction, score:

Methylmalonyl-CoA: 210.7
Ethylmalonyl-CoA: 194.1
Methoxymalonyl-CoA: 169.9
2-Methylbutyryl-CoA: 155.2
trans-1,2-CPDA: 136.9
CHC-CoA: 103.8
Malonyl-CoA: 101.9
Propionyl-CoA: 99.6
Isobutyryl-CoA: 90.3
Benzoyl-CoA: 52.4
3-Methylbutyryl-CoA: 47.8
Acetyl-CoA: 31.9
inactive: 28.4
fatty_acid: 25.5

Type II PKS gene cluster prediction details

Cluster section:: 0 to 39835
Starter unit(s):: 2-methylbutyryl-CoA (Score: 1938.0; E-value: 0)
malonamyl-CoA (Score: 583.0; E-value: 0)
propionyl-CoA (Score: 111.0; E-value: 3.91e-29)
Malonyl elongations:: 11|12 (Score: 698.3; E-value: 5.7e-213)
Product class(es):: pentangular polyphenol
Product molecular weight(s):: 2-methylbutyryl-CoA_11: 518.60 Da
2-methylbutyryl-CoA_12: 560.63 Da
malonamyl-CoA_11: 519.54 Da
malonamyl-CoA_12: 561.58 Da
propionyl-CoA_11: 490.54 Da
propionyl-CoA_12: 532.58 Da

ADB23379.1: AT (Score: 606.1; E-value: 4e-185); AT ADB23379.1_TLN-05220/TLN-05223_2-methylbutyryl-CoA (Score: 1215.0; E-value: 0.0)
ADB23384.1: AMID (Score: 790.3; E-value: 2.4e-240); AMID ADE34521.1_SF2575_malonamyl-CoA (Score: 583.0; E-value: 0.0)
ADB23385.1: MET C13O|C17O (Score: 505.0; E-value: 1.9e-154)
ADB23387.1: KR C11 (Score: 332.4; E-value: 3.6e-102)
ADB23389.1: CYC C4-C21/C2-C23|C2-C19 (Score: 182.4; E-value: 4e-57)
ADB23390.1: CYC C5-C18 (Score: 222.0; E-value: 4.2e-69)
ADB23391.1: KS (Score: 744.6; E-value: 6.6e-227)
ADB23392.1: CLF 11|12 (Score: 698.3; E-value: 5.7e-213)
ADB23393.1: ACP (Score: 109.2; E-value: 1.8e-34)
ADB23394.1: CYC C9-C14 (Score: 244.6; E-value: 6.8e-76)
ADB23395.1: KR C19 (Score: 405.1; E-value: 2.5e-124)
ADB23398.1: KSIII (Score: 532.4; E-value: 1e-162); KSIII ADB23398.1_TLN-05220/TLN-05223_2-methylbutyryl-CoA (Score: 723.0; E-value: 0.0)
ADB23401.1: OXY (Score: 297.1; E-value: 6.1e-91)
ADB23403.1: AT (Score: 164.1; E-value: 9.9e-51); AT AAF70110.1_Aclacinomycin_propionyl-CoA (Score: 111.0; E-value: 3.91e-29)