BGC0001213 - 1 region(s) - antiSMASH results

Identified secondary metabolite regions using strictness 'relaxed'

BGC0001213 (Streptomyces sp. Tu 6176)

Region	Type	From	To	Most similar known cluster		Similarity
Region 1	PKS-like,T1PKS,hglE-KS	1	45,517	A33853	Other	56%

BGC0001213 - Region 1 - PKS-like,T1PKS,hglE-KS

Download region GenBank file

Download region SVG

Location: 1 - 45,517 nt. (total: 45,517 nt) Show pHMM detection rules used

Region on contig edge.

PKS-like: (t2pks2 or ksIII)
T1PKS: cds(PKS_AT and (PKS_KS or ene_KS or mod_KS or hyb_KS or itr_KS or tra_KS))
hglE-KS: (hglE or hglD)

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

TTA codons

reset view

zoom to selection

Gene details

Select a gene to view the details available for it

MIBiG

NRPS/PKS domains

MIBiG comparison

KnownClusterBlast

NRPS/PKS modules

External annotation

Name		MIBiG
Version		3.0

Type		Subregion
Location		1 - 45,518
Label		BGC0001213

Detailed domain annotation

Selected features only

Show module domains

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001213.1	1.71	Polyketide	nataxazole	Streptomyces sp. Tu 6176
BGC0001444.1	0.96	Other	caboxamycin	Streptomyces sp. NTK 937
BGC0001909.1	0.94	Polyketide	strobilurin	Strobilurus tenacellus
BGC0001538.1	0.94	NRP, Polyketide	caboxamycin	Streptomyces sp. NTK 937
BGC0000889.1	0.85	Other	bagremycin A, bagremycin B	Streptomyces sp. WK-5344
BGC0001592.1	0.84	Other	ferroverdin	Streptomyces lunaelactis
BGC0002029.1	0.84	Other	bagremycin A, bagremycin B, bagremycin C, bagremycin E, bagremycin F, bagremycin G, ferroverdin A, ferroverdin B, ferroverdin C	Streptomyces lunaelactis
BGC0000046.1	0.79	Polyketide	depudecin	Alternaria brassicicola
BGC0000056.1	0.74	Polyketide	esperamicin	Actinomadura verrucosospora
BGC0001858.1	0.74	Polyketide	alternapyrone B, alternapyrone C, alternapyrone D, alternapyrone E, alternapyrone F	Parastagonospora nodorum SN15

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001213.1	0.87	Polyketide	nataxazole	Streptomyces sp. Tu 6176
BGC0001444.1	0.71	Other	caboxamycin	Streptomyces sp. NTK 937
BGC0001538.1	0.68	NRP, Polyketide	caboxamycin	Streptomyces sp. NTK 937
BGC0001909.1	0.65	Polyketide	strobilurin	Strobilurus tenacellus
BGC0002081.1	0.62	Polyketide	streptoketide A, streptoketide B, streptoketide C, S2502, S2507, UWM5	Streptomyces sp. Tue6314
BGC0000889.1	0.62	Other	bagremycin A, bagremycin B	Streptomyces sp. WK-5344
BGC0001592.1	0.62	Other	ferroverdin	Streptomyces lunaelactis
BGC0002029.1	0.62	Other	bagremycin A, bagremycin B, bagremycin C, bagremycin E, bagremycin F, bagremycin G, ferroverdin A, ferroverdin B, ferroverdin C	Streptomyces lunaelactis
BGC0000046.1	0.60	Polyketide	depudecin	Alternaria brassicicola
BGC0000218.1	0.59	Polyketide	doxorubicin	Streptomyces peucetius

Similar known gene clusters

Module view

Legend

NRPS/PKS products

NRPS/PKS monomers

Predicted core structure(s)

For candidate cluster 1, location 6287 - 45517:

Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:: (pk)

Direct lookup in NORINE database: strict or relaxed

For candidate cluster 2, location 9937 - 45517:

Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:: (pk)

Direct lookup in NORINE database: strict or relaxed

For candidate cluster 3, location 22644 - 45517:

Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:: (pk)

Direct lookup in NORINE database: strict or relaxed

Link to NORINE database query form

NRPS/PKS monomer predictions

CF54_07370

Search NORINE for peptide: strict or relaxed

AMP-binding (31..439): pip

NRPSPredictor2: pip

SVM prediction details:

NOTE: outside applicability domain

Predicted physicochemical class:: hydrophobic-aliphatic
Large clusters prediction:: pro, pip
Small clusters prediction:: dhb, sal
Single AA prediction:: pip

Stachelhaus prediction details:

Stachelhaus sequence:: aFPaQGVLTK
Nearest Stachelhaus code:: pip
Stachelhaus code match:: 80% (moderate)

CF54_07380

Search NORINE for peptide: strict or relaxed

AMP-binding (65..248): X

NRPSPredictor2: (unknown)

SVM prediction details:

NOTE: outside applicability domain

Predicted physicochemical class:: hydrophobic-aliphatic
Large clusters prediction:: N/A
Small clusters prediction:: N/A
Single AA prediction:: N/A

Stachelhaus prediction details:

Stachelhaus sequence:: vILW-----K
Nearest Stachelhaus code:: tcl
Stachelhaus code match:: 40% (weak)

CF54_07385

PKS_AT (504..794): pk

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 87.5%; Methylmalonyl-CoA: 70.8%; Propionyl-CoA: 62.5%

minowa: Methylmalonyl-CoA

Prediction, score:

Methylmalonyl-CoA: 125.9
Methoxymalonyl-CoA: 103.8
Ethylmalonyl-CoA: 103.8
Malonyl-CoA: 91.8
2-Methylbutyryl-CoA: 60.5
Propionyl-CoA: 56.8
Isobutyryl-CoA: 55.6
trans-1,2-CPDA: 51.9
CHC-CoA: 45.8
fatty_acid: 32.9
3-Methylbutyryl-CoA: 32.9
Acetyl-CoA: 24.4
inactive: 23.9
Benzoyl-CoA: 23.1

CF54_07415

PKS_AT (570..870): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 75.0%; inactive: 66.7%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 93.1
Methoxymalonyl-CoA: 48.8
inactive: 40.4
Methylmalonyl-CoA: 37.0
trans-1,2-CPDA: 16.1
Propionyl-CoA: 14.6
fatty_acid: 13.3
Isobutyryl-CoA: 10.3
Ethylmalonyl-CoA: 5.8
Benzoyl-CoA: 0.0
Acetyl-CoA: 0.0
3-Methylbutyryl-CoA: 0.0
2-Methylbutyryl-CoA: 0.0
CHC-CoA: -2.1