BGC0001246 - 1 region(s) - antiSMASH results

Identified secondary metabolite regions using strictness 'relaxed'

BGC0001246 (Sarocladium zeae)

Region	Type	From	To	Most similar known cluster		Similarity
Region 1	T1PKS	1	28,428	dehydrocurvularin	Polyketide	50%

BGC0001246 - Region 1 - T1PKS

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Location: 1 - 28,428 nt. (total: 28,428 nt) Show pHMM detection rules used

Region on contig edge.

T1PKS: cds(PKS_AT and (PKS_KS or ene_KS or mod_KS or hyb_KS or itr_KS or tra_KS))

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core biosynthetic genes

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Gene details

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MIBiG

NRPS/PKS domains

MIBiG comparison

KnownClusterBlast

NRPS/PKS modules

External annotation

Name		MIBiG
Version		3.0

Type		Subregion
Location		1 - 28,429
Label		BGC0001246

Detailed domain annotation

Selected features only

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Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001246.1	0.67	Polyketide	trans-resorcylide	Sarocladium zeae
BGC0000045.1	0.26	Polyketide	dehydrocurvularin	Aspergillus terreus
BGC0000056.1	0.23	Polyketide	esperamicin	Actinomadura verrucosospora
BGC0000046.1	0.22	Polyketide	depudecin	Alternaria brassicicola
BGC0001124.1	0.21	Polyketide	pyranonigrin E	Aspergillus niger ATCC 1015
BGC0000041.1	0.21	Polyketide	oronofacic acid	Pseudomonas syringae
BGC0001244.1	0.21	Polyketide	(-)-Mellein	Parastagonospora nodorum
BGC0001275.1	0.21	Polyketide	6-methylsalicyclic acid	Glarea lozoyensis
BGC0001273.1	0.21	Polyketide	asperlactone	Aspergillus ochraceus
BGC0000107.1	0.21	Polyketide	naphthopyrone	Aspergillus nidulans FGSC A4

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001246.1	0.87	Polyketide	trans-resorcylide	Sarocladium zeae
BGC0000045.1	0.60	Polyketide	dehydrocurvularin	Aspergillus terreus
BGC0000056.1	0.56	Polyketide	esperamicin	Actinomadura verrucosospora
BGC0000046.1	0.55	Polyketide	depudecin	Alternaria brassicicola
BGC0001124.1	0.54	Polyketide	pyranonigrin E	Aspergillus niger ATCC 1015
BGC0000041.1	0.54	Polyketide	oronofacic acid	Pseudomonas syringae
BGC0001244.1	0.54	Polyketide	(-)-Mellein	Parastagonospora nodorum
BGC0001275.1	0.54	Polyketide	6-methylsalicyclic acid	Glarea lozoyensis
BGC0001273.1	0.54	Polyketide	asperlactone	Aspergillus ochraceus
BGC0000107.1	0.54	Polyketide	naphthopyrone	Aspergillus nidulans FGSC A4

Similar known gene clusters

Module view

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NRPS/PKS products

NRPS/PKS monomers

Predicted core structure(s)

For candidate cluster 1, location 0 - 28428:

Rough prediction of core scaffold based on assumed PKS linker matching; tailoring reactions not taken into account

Polymer prediction:: (pk) + (mal)
Non-colinear ordering:: resS1 + resS2

Direct lookup in NORINE database: strict or relaxed

Link to NORINE database query form

NRPS/PKS monomer predictions

resS1

PKS_AT (555..871): pk

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 87.5%; Ethylmalonyl-CoA: 70.8%; Methylmalonyl-CoA: 70.8%

minowa: Methylmalonyl-CoA

Prediction, score:

Methylmalonyl-CoA: 99.8
Methoxymalonyl-CoA: 86.4
Malonyl-CoA: 78.3
Ethylmalonyl-CoA: 64.9
Isobutyryl-CoA: 54.2
Benzoyl-CoA: 37.1
Propionyl-CoA: 31.5
2-Methylbutyryl-CoA: 28.2
trans-1,2-CPDA: 22.0
CHC-CoA: 19.6
inactive: 12.5
fatty_acid: 10.1
Acetyl-CoA: 0.0
3-Methylbutyryl-CoA: 0.0

resS2

PKS_AT (955..1267): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 62.5%; Methylmalonyl-CoA: 58.3%; inactive: 58.3%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 97.1
Methoxymalonyl-CoA: 59.4
inactive: 59.1
Methylmalonyl-CoA: 58.3
Isobutyryl-CoA: 47.8
Propionyl-CoA: 37.9
Benzoyl-CoA: 32.2
CHC-CoA: 21.8
2-Methylbutyryl-CoA: 20.8
Acetyl-CoA: 19.6
3-Methylbutyryl-CoA: 19.2
trans-1,2-CPDA: 18.1
Ethylmalonyl-CoA: 18.1
fatty_acid: 12.5