BGC0001293 - 1 region(s) - antiSMASH results

Identified secondary metabolite regions using strictness 'relaxed'

BGC0001293 (Streptomyces sp. NCIB 11649)

Region	Type	From	To	Most similar known cluster		Similarity
Region 1	T1PKS	1	49,740	halstoctacosanolide A	Polyketide	77%

BGC0001293 - Region 1 - T1PKS

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Location: 1 - 49,740 nt. (total: 49,740 nt) Show pHMM detection rules used

Region on contig edge.

T1PKS: cds(PKS_AT and (PKS_KS or ene_KS or mod_KS or hyb_KS or itr_KS or tra_KS))

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core biosynthetic genes

additional biosynthetic genes

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Gene details

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MIBiG

NRPS/PKS domains

MIBiG comparison

KnownClusterBlast

NRPS/PKS modules

External annotation

Name		MIBiG
Version		3.0

Type		Subregion
Location		1 - 49,741
Label		BGC0001293

Detailed domain annotation

Selected features only

Show module domains

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001293.1	0.86	Polyketide	cyclizidine	Streptomyces sp. NCIB 11649
BGC0001276.1	0.37	Polyketide	6-methylsalicyclic acid	Aspergillus terreus
BGC0000041.1	0.37	Polyketide	oronofacic acid	Pseudomonas syringae
BGC0001244.1	0.36	Polyketide	(-)-Mellein	Parastagonospora nodorum
BGC0001273.1	0.36	Polyketide	asperlactone	Aspergillus ochraceus
BGC0000068.1	0.35	Polyketide	geldanamycin	Streptomyces hygroscopicus
BGC0001275.1	0.35	Polyketide	6-methylsalicyclic acid	Glarea lozoyensis
BGC0001909.1	0.32	Polyketide	strobilurin	Strobilurus tenacellus
BGC0000170.1	0.31	Polyketide	yanuthone D	Aspergillus niger ATCC 1015
BGC0000067.1	0.29	Polyketide	geldanamycin	Streptomyces hygroscopicus subsp. duamyceticus

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001293.1	0.95	Polyketide	cyclizidine	Streptomyces sp. NCIB 11649
BGC0001276.1	0.69	Polyketide	6-methylsalicyclic acid	Aspergillus terreus
BGC0000041.1	0.69	Polyketide	oronofacic acid	Pseudomonas syringae
BGC0001244.1	0.69	Polyketide	(-)-Mellein	Parastagonospora nodorum
BGC0001273.1	0.69	Polyketide	asperlactone	Aspergillus ochraceus
BGC0000068.1	0.68	Polyketide	geldanamycin	Streptomyces hygroscopicus
BGC0001275.1	0.68	Polyketide	6-methylsalicyclic acid	Glarea lozoyensis
BGC0001909.1	0.66	Polyketide	strobilurin	Strobilurus tenacellus
BGC0000170.1	0.65	Polyketide	yanuthone D	Aspergillus niger ATCC 1015
BGC0000067.1	0.63	Polyketide	geldanamycin	Streptomyces hygroscopicus subsp. duamyceticus

Similar known gene clusters

Module view

Legend

NRPS/PKS products

NRPS/PKS monomers

Predicted core structure(s)

For candidate cluster 1, location 0 - 49740:

Rough prediction of core scaffold based on assumed PKS linker matching; tailoring reactions not taken into account

Polymer prediction:: (Me-redmal - ccmal) + (Me-ccmal - ccmal) + (Me-mal - ccmal) + (ccmal)
Non-colinear ordering:: cycC + cycE + cycF + cycB

Direct lookup in NORINE database: strict or relaxed

Link to NORINE database query form

NRPS/PKS monomer predictions

cycB

PKS_AT (556..855): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 91.7%; inactive: 79.2%; Isobutyryl-CoA: 54.2%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 185.1
inactive: 92.9
Methylmalonyl-CoA: 60.6
Methoxymalonyl-CoA: 57.1
Propionyl-CoA: 37.9
Acetyl-CoA: 37.1
Isobutyryl-CoA: 35.8
Ethylmalonyl-CoA: 35.1
Benzoyl-CoA: 26.9
fatty_acid: 19.3
CHC-CoA: 18.1
2-Methylbutyryl-CoA: 15.2
trans-1,2-CPDA: 9.7
3-Methylbutyryl-CoA: 0.0

cycC

PKS_AT (348..673): mmal

ATSignature: Methylmalonyl-CoA

Top 3 matches:: Methylmalonyl-CoA: 100.0%; Methoxymalonyl-CoA: 95.8%; Ethylmalonyl-CoA: 91.7%

minowa: Methylmalonyl-CoA

Prediction, score:

Methylmalonyl-CoA: 195.8
Ethylmalonyl-CoA: 183.0
Methoxymalonyl-CoA: 163.9
2-Methylbutyryl-CoA: 133.1
trans-1,2-CPDA: 104.6
Malonyl-CoA: 93.3
Propionyl-CoA: 92.7
CHC-CoA: 81.6
Isobutyryl-CoA: 56.3
Benzoyl-CoA: 37.8
Acetyl-CoA: 35.2
inactive: 28.3
fatty_acid: 26.7
3-Methylbutyryl-CoA: 24.7

PKS_AT (2468..2767): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 91.7%; inactive: 79.2%; Isobutyryl-CoA: 54.2%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 183.9
inactive: 97.0
Methoxymalonyl-CoA: 58.7
Methylmalonyl-CoA: 57.0
Isobutyryl-CoA: 36.9
Acetyl-CoA: 36.8
Propionyl-CoA: 35.9
Ethylmalonyl-CoA: 35.2
Benzoyl-CoA: 29.8
fatty_acid: 26.8
CHC-CoA: 18.4
2-Methylbutyryl-CoA: 12.6
trans-1,2-CPDA: 12.5
3-Methylbutyryl-CoA: 0.0

cycE

PKS_AT (578..885): mmal

ATSignature: Methylmalonyl-CoA

Top 3 matches:: Methylmalonyl-CoA: 100.0%; Methoxymalonyl-CoA: 95.8%; Ethylmalonyl-CoA: 91.7%

minowa: Methylmalonyl-CoA

Prediction, score:

Methylmalonyl-CoA: 200.5
Ethylmalonyl-CoA: 185.0
Methoxymalonyl-CoA: 167.4
2-Methylbutyryl-CoA: 141.4
Malonyl-CoA: 113.2
trans-1,2-CPDA: 112.3
CHC-CoA: 107.8
Propionyl-CoA: 105.2
Isobutyryl-CoA: 62.9
Benzoyl-CoA: 50.0
Acetyl-CoA: 41.6
3-Methylbutyryl-CoA: 37.1
inactive: 35.9
fatty_acid: 30.2

PKS_AT (2339..2638): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 91.7%; inactive: 79.2%; Isobutyryl-CoA: 54.2%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 183.9
inactive: 93.2
Methylmalonyl-CoA: 57.7
Methoxymalonyl-CoA: 57.6
Propionyl-CoA: 36.3
Isobutyryl-CoA: 34.0
Acetyl-CoA: 31.6
Ethylmalonyl-CoA: 27.1
fatty_acid: 22.1
CHC-CoA: 16.2
Benzoyl-CoA: 15.4
trans-1,2-CPDA: 14.0
3-Methylbutyryl-CoA: 0.0
2-Methylbutyryl-CoA: -0.4

cycF

PKS_AT (283..585): mmal

ATSignature: Methylmalonyl-CoA

Top 3 matches:: Methylmalonyl-CoA: 100.0%; Methoxymalonyl-CoA: 95.8%; Ethylmalonyl-CoA: 91.7%

minowa: Methylmalonyl-CoA

Prediction, score:

Methylmalonyl-CoA: 195.7
Ethylmalonyl-CoA: 183.6
Methoxymalonyl-CoA: 156.9
2-Methylbutyryl-CoA: 138.4
trans-1,2-CPDA: 134.0
Propionyl-CoA: 111.0
CHC-CoA: 87.1
Malonyl-CoA: 86.5
Isobutyryl-CoA: 47.2
fatty_acid: 32.3
3-Methylbutyryl-CoA: 30.3
Benzoyl-CoA: 29.1
Acetyl-CoA: 22.2
inactive: 19.7

PKS_AT (1308..1607): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 91.7%; inactive: 79.2%; Isobutyryl-CoA: 54.2%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 187.5
inactive: 93.9
Methylmalonyl-CoA: 59.4
Methoxymalonyl-CoA: 57.5
Acetyl-CoA: 39.7
Propionyl-CoA: 38.7
Isobutyryl-CoA: 36.5
Ethylmalonyl-CoA: 31.9
fatty_acid: 22.1
CHC-CoA: 19.7
Benzoyl-CoA: 17.7
trans-1,2-CPDA: 13.9
3-Methylbutyryl-CoA: 0.0
2-Methylbutyryl-CoA: -0.4