BGC0001491 - 1 region(s) - antiSMASH results

Identified secondary metabolite regions using strictness 'relaxed'

BGC0001491 (Couchioplanes caeruleus subsp. caeruleus)

Region	Type	From	To	Similarity Confidence	Most similar known cluster
Region 1	T1PKS,NRPS-like	1	130,524	High	67-121C	PKS

BGC0001491 - Region 1 - NRPS-like,T1PKS

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Location: 1 - 130,524 nt. (total: 130,524 nt) Show pHMM detection rules used

Region on contig edge.

T1PKS: cds(PKS_AT and (PKS_KS or ene_KS or mod_KS or hyb_KS or itr_KS or tra_KS))
NRPS-like: cds((PP-binding or NAD_binding_4) and (AMP-binding or A-OX) and not alpha_am_amid)

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core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

TTA codons

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Gene details

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Gene overview

MIBiG

Tailoring

MIBiG comparison

KnownClusterBlast

NRPS/PKS modules

NRPS/PKS domains

Gene/CDS overview

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Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

External annotation

Name		MIBiG
Version		4.0alpha

Type		Subregion
Location		1 - 130,525
Label		BGC0001491

Tailoring functions

Oxidoreductases: oxygenase

BG844_00095: cytochrome P450

smcogs: SMCOG1007: cytochrome P450

Transferases: aminotransferase glycosyltransferase transferase

BG844_00015: acetyl-CoA carboxylase, carboxyl transferase,

smcogs: SMCOG1059: acetyl-CoA carboxylase, carboxyl transferase,

BG844_00100: DegT/DnrJ/EryC1/StrS aminotransferase

smcogs: SMCOG1056: DegT/DnrJ/EryC1/StrS aminotransferase

BG844_00105: glycosyltransferase, MGT family

smcogs: SMCOG1062: glycosyltransferase, MGT family

Hydrolases: esterase

BG844_00085: thioesterase

smcogs: SMCOG1004: thioesterase

Lyases: dehydratase

BG844_00035: NAD-dependent epimerase/dehydratase

smcogs: SMCOG1010: NAD-dependent epimerase/dehydratase

Isomerases: isomerase

BG844_00080: isochorismate synthase

smcogs: SMCOG1018: isochorismate synthase

Ligases: synthase

BG844_00045: Beta-ketoacyl synthase

smcogs: SMCOG1022: Beta-ketoacyl synthase

BG844_00050: Beta-ketoacyl synthase

smcogs: SMCOG1022: Beta-ketoacyl synthase

BG844_00055: Beta-ketoacyl synthase

smcogs: SMCOG1022: Beta-ketoacyl synthase

BG844_00060: Beta-ketoacyl synthase

smcogs: SMCOG1022: Beta-ketoacyl synthase

BG844_00065: Beta-ketoacyl synthase

smcogs: SMCOG1022: Beta-ketoacyl synthase

BG844_00075: Beta-ketoacyl synthase

smcogs: SMCOG1022: Beta-ketoacyl synthase

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001491.3	1.33	PKS	67-121C	Couchioplanes caeruleus subsp. caeruleus
BGC0001273.3	0.77	PKS	asperlactone	Aspergillus ochraceus
BGC0001244.3	0.76	PKS	(-)-Mellein	Parastagonospora nodorum
BGC0002154.2	0.66	PKS	1,3,5,8-tetrahydroxynapthalene, 1-(alpha-l-(2-O-methyl)-6-deoxymannopyranosyloxy)-3,6,8-trimethoxynaphthalene	Pyricularia oryzae 70-15
BGC0001254.3	0.59	PKS	ACT-Toxin II	Alternaria alternata
BGC0000037.4	0.59	PKS	cichorine	Aspergillus nidulans FGSC A4
BGC0002192.3	0.59	PKS	FR901512	fungal sp. No.14919
BGC0001160.5	0.57	PKS	1-nonadecene, (14Z)-1,14-nonadecadiene	Synechococcus sp. PCC 7002
BGC0001164.3	0.57	PKS	1-heptadecene	Cyanothece sp. PCC 7822
BGC0001268.4	0.56	NRPS, PKS	fusarin C	Fusarium fujikuroi

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001491.3	1.00	PKS	67-121C	Couchioplanes caeruleus subsp. caeruleus
BGC0001273.3	0.76	PKS	asperlactone	Aspergillus ochraceus
BGC0001244.3	0.76	PKS	(-)-Mellein	Parastagonospora nodorum
BGC0001276.3	0.75	PKS	6-methylsalicyclic acid	Aspergillus terreus
BGC0002154.2	0.66	PKS	1,3,5,8-tetrahydroxynapthalene, 1-(alpha-l-(2-O-methyl)-6-deoxymannopyranosyloxy)-3,6,8-trimethoxynaphthalene	Pyricularia oryzae 70-15
BGC0001254.3	0.64	PKS	ACT-Toxin II	Alternaria alternata
BGC0002192.3	0.64	PKS	FR901512	fungal sp. No.14919
BGC0000041.3	0.64	PKS	oronofacic acid	Pseudomonas syringae
BGC0000037.4	0.63	PKS	cichorine	Aspergillus nidulans FGSC A4
BGC0001160.5	0.63	PKS	1-nonadecene, (14Z)-1,14-nonadecadiene	Synechococcus sp. PCC 7002

Similar known clusters from MIBiG 4.0

Module view

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Detailed domain annotation

Selected features only

Show module domains

NRPS/PKS products

NRPS/PKS substrates

Predicted core structure(s)

For candidate cluster 1, location 0 - 130524:

Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:: (ccmal - ohmal - Me-ohmal - ohmal - mal - ohmal) + (ccmal - ccmal) + (ccmal - ohmal - ccmal) + (ohmal - pk - Me-ccmal) + (ccmal - ccmal - ccmal - ccmal - ccmal - ccmal) + (X - mal)

Direct lookup in NORINE database: strict or relaxed

Link to NORINE database query form

NRPS/PKS substrate predictions

BG844_00045: mal - mal - mmal - mal - mal - mal

PKS_AT (552..832): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 87.5%; inactive: 70.8%; Propionyl-CoA: 54.2%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 180.2
inactive: 89.3
Methoxymalonyl-CoA: 57.0
Methylmalonyl-CoA: 44.4
Isobutyryl-CoA: 21.2
Benzoyl-CoA: 18.7
Ethylmalonyl-CoA: 17.9
Acetyl-CoA: 17.3
Propionyl-CoA: 14.7
fatty_acid: 8.1
CHC-CoA: 7.1
trans-1,2-CPDA: 4.3
2-Methylbutyryl-CoA: 3.3
3-Methylbutyryl-CoA: 0.0

PKS_AT (2219..2497): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 91.7%; inactive: 75.0%; Propionyl-CoA: 54.2%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 176.2
inactive: 93.6
Methoxymalonyl-CoA: 57.3
Methylmalonyl-CoA: 45.3
Ethylmalonyl-CoA: 19.9
Isobutyryl-CoA: 18.0
Benzoyl-CoA: 16.0
Propionyl-CoA: 13.5
Acetyl-CoA: 10.5
fatty_acid: 8.1
CHC-CoA: 5.3
trans-1,2-CPDA: 4.1
2-Methylbutyryl-CoA: 3.9
3-Methylbutyryl-CoA: 0.0

PKS_AT (3717..4013): mmal

ATSignature: Methylmalonyl-CoA

Top 3 matches:: Methylmalonyl-CoA: 100.0%; Methoxymalonyl-CoA: 95.8%; Ethylmalonyl-CoA: 91.7%

minowa: Methylmalonyl-CoA

Prediction, score:

Methylmalonyl-CoA: 218.1
Ethylmalonyl-CoA: 210.4
Methoxymalonyl-CoA: 174.4
2-Methylbutyryl-CoA: 144.2
trans-1,2-CPDA: 131.7
Propionyl-CoA: 122.7
CHC-CoA: 107.9
Malonyl-CoA: 106.6
Isobutyryl-CoA: 94.9
Benzoyl-CoA: 72.6
fatty_acid: 39.4
Acetyl-CoA: 38.3
3-Methylbutyryl-CoA: 35.7
inactive: 28.6

PKS_AT (5200..5481): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 91.7%; inactive: 70.8%; Propionyl-CoA: 58.3%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 198.1
inactive: 108.2
Methoxymalonyl-CoA: 56.3
Methylmalonyl-CoA: 44.4
Isobutyryl-CoA: 27.5
Acetyl-CoA: 15.4
Ethylmalonyl-CoA: 10.6
CHC-CoA: 6.3
Benzoyl-CoA: 5.4
Propionyl-CoA: 1.6
trans-1,2-CPDA: 0.0
fatty_acid: 0.0
3-Methylbutyryl-CoA: 0.0
2-Methylbutyryl-CoA: 0.0

PKS_AT (6617..6885): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 91.7%; inactive: 75.0%; Methylmalonyl-CoA: 54.2%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 188.4
inactive: 84.4
Methoxymalonyl-CoA: 59.5
Methylmalonyl-CoA: 49.3
Propionyl-CoA: 27.1
Isobutyryl-CoA: 22.6
Ethylmalonyl-CoA: 20.2
Acetyl-CoA: 15.6
Benzoyl-CoA: 14.5
fatty_acid: 11.6
CHC-CoA: 5.4
2-Methylbutyryl-CoA: 5.3
trans-1,2-CPDA: 0.0
3-Methylbutyryl-CoA: 0.0

PKS_AT (7969..8262): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 95.8%; inactive: 79.2%; Methylmalonyl-CoA: 54.2%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 221.9
inactive: 112.2
Methoxymalonyl-CoA: 68.2
Methylmalonyl-CoA: 59.0
Propionyl-CoA: 28.5
Ethylmalonyl-CoA: 26.7
Isobutyryl-CoA: 24.5
fatty_acid: 22.8
Benzoyl-CoA: 19.0
Acetyl-CoA: 17.0
CHC-CoA: 15.7
2-Methylbutyryl-CoA: 13.2
trans-1,2-CPDA: 10.3
3-Methylbutyryl-CoA: 0.0

BG844_00050: mal - mal

PKS_AT (534..790): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 87.5%; inactive: 70.8%; Methylmalonyl-CoA: 54.2%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 187.2
inactive: 90.5
Methoxymalonyl-CoA: 59.1
Methylmalonyl-CoA: 42.5
Propionyl-CoA: 29.5
Acetyl-CoA: 19.6
Isobutyryl-CoA: 15.8
fatty_acid: 14.9
Benzoyl-CoA: 14.1
Ethylmalonyl-CoA: 13.0
trans-1,2-CPDA: 0.0
CHC-CoA: 0.0
3-Methylbutyryl-CoA: 0.0
2-Methylbutyryl-CoA: 0.0

PKS_AT (2055..2312): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 91.7%; inactive: 79.2%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 198.3
inactive: 99.2
Methoxymalonyl-CoA: 56.6
Methylmalonyl-CoA: 39.8
Isobutyryl-CoA: 21.0
Propionyl-CoA: 19.5
Benzoyl-CoA: 14.7
Acetyl-CoA: 14.6
Ethylmalonyl-CoA: 11.5
fatty_acid: 9.1
trans-1,2-CPDA: 0.0
CHC-CoA: 0.0
3-Methylbutyryl-CoA: 0.0
2-Methylbutyryl-CoA: 0.0

BG844_00055: mal - mal - mal

PKS_AT (536..792): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 91.7%; inactive: 79.2%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 197.1
inactive: 99.5
Methoxymalonyl-CoA: 56.2
Methylmalonyl-CoA: 42.0
Propionyl-CoA: 21.8
Ethylmalonyl-CoA: 17.2
fatty_acid: 16.5
Acetyl-CoA: 16.5
Benzoyl-CoA: 13.4
Isobutyryl-CoA: 10.9
trans-1,2-CPDA: 0.0
CHC-CoA: 0.0
3-Methylbutyryl-CoA: 0.0
2-Methylbutyryl-CoA: 0.0

PKS_AT (2127..2382): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 91.7%; inactive: 79.2%; Methylmalonyl-CoA: 54.2%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 187.8
inactive: 92.8
Methoxymalonyl-CoA: 51.5
Methylmalonyl-CoA: 42.2
Propionyl-CoA: 20.4
Isobutyryl-CoA: 20.3
Benzoyl-CoA: 18.9
Acetyl-CoA: 17.0
fatty_acid: 14.0
Ethylmalonyl-CoA: 10.9
CHC-CoA: 9.5
trans-1,2-CPDA: 0.0
3-Methylbutyryl-CoA: 0.0
2-Methylbutyryl-CoA: 0.0

PKS_AT (3566..3821): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 91.7%; inactive: 79.2%; Methylmalonyl-CoA: 54.2%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 187.8
inactive: 92.8
Methoxymalonyl-CoA: 51.5
Methylmalonyl-CoA: 42.2
Propionyl-CoA: 20.4
Isobutyryl-CoA: 20.3
Benzoyl-CoA: 18.9
Acetyl-CoA: 17.0
fatty_acid: 14.0
Ethylmalonyl-CoA: 10.9
CHC-CoA: 9.5
trans-1,2-CPDA: 0.0
3-Methylbutyryl-CoA: 0.0
2-Methylbutyryl-CoA: 0.0

BG844_00060: mal - pk - mmal

PKS_AT (548..816): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 87.5%; inactive: 70.8%; Propionyl-CoA: 54.2%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 167.4
inactive: 74.6
Methoxymalonyl-CoA: 62.2
Methylmalonyl-CoA: 52.8
Ethylmalonyl-CoA: 31.5
Acetyl-CoA: 16.5
Benzoyl-CoA: 16.4
Isobutyryl-CoA: 16.3
Propionyl-CoA: 16.2
trans-1,2-CPDA: 12.2
CHC-CoA: 9.7
2-Methylbutyryl-CoA: 9.2
fatty_acid: 8.6
3-Methylbutyryl-CoA: 0.0

PKS_AT (1916..2209): pk

ATSignature: Methylmalonyl-CoA

Top 3 matches:: Methylmalonyl-CoA: 95.8%; Methoxymalonyl-CoA: 91.7%; Ethylmalonyl-CoA: 87.5%

minowa: Ethylmalonyl-CoA

Prediction, score:

Ethylmalonyl-CoA: 218.1
Methylmalonyl-CoA: 217.2
Methoxymalonyl-CoA: 177.3
2-Methylbutyryl-CoA: 148.2
trans-1,2-CPDA: 134.7
Propionyl-CoA: 104.4
CHC-CoA: 100.1
Malonyl-CoA: 95.1
Isobutyryl-CoA: 88.9
Benzoyl-CoA: 61.5
Acetyl-CoA: 45.3
3-Methylbutyryl-CoA: 44.7
fatty_acid: 43.6
inactive: 33.3

PKS_AT (3897..4190): mmal

ATSignature: Methylmalonyl-CoA

Top 3 matches:: Methylmalonyl-CoA: 100.0%; Methoxymalonyl-CoA: 95.8%; Ethylmalonyl-CoA: 91.7%

minowa: Methylmalonyl-CoA

Prediction, score:

Methylmalonyl-CoA: 212.9
Ethylmalonyl-CoA: 201.9
Methoxymalonyl-CoA: 183.6
2-Methylbutyryl-CoA: 146.2
trans-1,2-CPDA: 139.1
Propionyl-CoA: 116.1
Malonyl-CoA: 103.1
CHC-CoA: 99.7
Isobutyryl-CoA: 84.0
Benzoyl-CoA: 65.9
3-Methylbutyryl-CoA: 49.7
Acetyl-CoA: 44.5
inactive: 38.3
fatty_acid: 23.4

BG844_00065: mal - mal - mal - mal - mal - mal

PKS_AT (561..817): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 91.7%; inactive: 79.2%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 195.7
inactive: 103.2
Methoxymalonyl-CoA: 65.2
Methylmalonyl-CoA: 50.9
Isobutyryl-CoA: 27.0
Benzoyl-CoA: 22.7
Propionyl-CoA: 22.3
fatty_acid: 18.4
Ethylmalonyl-CoA: 16.7
Acetyl-CoA: 15.0
CHC-CoA: 10.5
3-Methylbutyryl-CoA: 6.2
trans-1,2-CPDA: 5.2
2-Methylbutyryl-CoA: 4.6

PKS_AT (2133..2394): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 91.7%; inactive: 75.0%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 186.5
inactive: 97.7
Methoxymalonyl-CoA: 61.9
Methylmalonyl-CoA: 52.1
Propionyl-CoA: 25.5
Isobutyryl-CoA: 23.6
Benzoyl-CoA: 22.1
Ethylmalonyl-CoA: 18.8
Acetyl-CoA: 17.2
fatty_acid: 12.6
CHC-CoA: 9.7
2-Methylbutyryl-CoA: 9.5
trans-1,2-CPDA: 7.7
3-Methylbutyryl-CoA: 0.0

PKS_AT (3717..3978): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 95.8%; inactive: 79.2%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 189.7
inactive: 97.4
Methoxymalonyl-CoA: 61.5
Methylmalonyl-CoA: 46.2
Propionyl-CoA: 25.5
Ethylmalonyl-CoA: 22.6
Benzoyl-CoA: 22.1
Acetyl-CoA: 18.6
Isobutyryl-CoA: 17.8
fatty_acid: 16.7
2-Methylbutyryl-CoA: 14.9
CHC-CoA: 7.8
trans-1,2-CPDA: 7.6
3-Methylbutyryl-CoA: 0.0

PKS_AT (5318..5579): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 91.7%; inactive: 79.2%; Methylmalonyl-CoA: 54.2%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 199.8
inactive: 104.0
Methoxymalonyl-CoA: 62.7
Methylmalonyl-CoA: 49.0
fatty_acid: 24.8
Propionyl-CoA: 24.7
Benzoyl-CoA: 21.3
Isobutyryl-CoA: 19.7
Ethylmalonyl-CoA: 17.9
Acetyl-CoA: 15.1
CHC-CoA: 8.5
2-Methylbutyryl-CoA: 7.6
trans-1,2-CPDA: 0.0
3-Methylbutyryl-CoA: 0.0

PKS_AT (6915..7172): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 91.7%; inactive: 75.0%; Methylmalonyl-CoA: 54.2%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 180.5
inactive: 85.1
Methoxymalonyl-CoA: 59.6
Methylmalonyl-CoA: 48.6
Propionyl-CoA: 32.4
Isobutyryl-CoA: 26.9
Benzoyl-CoA: 20.1
Ethylmalonyl-CoA: 19.4
Acetyl-CoA: 19.4
fatty_acid: 14.4
CHC-CoA: 12.1
2-Methylbutyryl-CoA: 10.9
trans-1,2-CPDA: 7.9
3-Methylbutyryl-CoA: 0.0

PKS_AT (8495..8756): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 91.7%; inactive: 79.2%; Methylmalonyl-CoA: 54.2%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 199.8
inactive: 104.0
Methoxymalonyl-CoA: 62.7
Methylmalonyl-CoA: 49.0
fatty_acid: 24.8
Propionyl-CoA: 24.7
Benzoyl-CoA: 21.3
Isobutyryl-CoA: 19.7
Ethylmalonyl-CoA: 17.9
Acetyl-CoA: 15.1
CHC-CoA: 8.5
2-Methylbutyryl-CoA: 7.6
trans-1,2-CPDA: 0.0
3-Methylbutyryl-CoA: 0.0

BG844_00075: X - mal

AMP-binding (29..424): X

nrpys: (unknown)

SVM prediction details:

Predicted physicochemical class:: N/A
Large clusters prediction:: N/A
Small clusters prediction:: N/A
Single AA prediction:: N/A

Stachelhaus prediction details:

Stachelhaus sequence:: LFQFRAVTGK
Nearest Stachelhaus code(s):
Stachelhaus code match:: 0% (weak)

PKS_AT (1135..1393): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 91.7%; inactive: 70.8%; Methylmalonyl-CoA: 54.2%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 178.8
inactive: 92.2
Methoxymalonyl-CoA: 65.8
Methylmalonyl-CoA: 48.4
Isobutyryl-CoA: 36.5
Propionyl-CoA: 19.6
fatty_acid: 17.8
Benzoyl-CoA: 17.5
Acetyl-CoA: 16.8
Ethylmalonyl-CoA: 14.3
trans-1,2-CPDA: 13.9
CHC-CoA: 13.8
3-Methylbutyryl-CoA: 0.0
2-Methylbutyryl-CoA: 0.0

Link to PARAS substrate predictor