BGC0001574 - 1 region(s) - antiSMASH results

Identified secondary metabolite regions using strictness 'relaxed'

BGC0001574 (Streptomyces thioluteus)

Region	Type	From	To	Most similar known cluster		Similarity
Region 1	NRPS	1	24,094	amycomicin	Polyketide	37%

BGC0001574 - Region 1 - NRPS

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Location: 1 - 24,094 nt. (total: 24,094 nt) Show pHMM detection rules used

Region on contig edge.

NRPS: cds(Condensation and (AMP-binding or A-OX))

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core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

TTA codons

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Gene details

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MIBiG

NRPS/PKS domains

MIBiG comparison

KnownClusterBlast

NRPS/PKS modules

External annotation

Name		MIBiG
Version		3.0

Type		Subregion
Location		1 - 24,095
Label		BGC0001574

Detailed domain annotation

Selected features only

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Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001574.1	0.98	NRP	diisonitrile antibiotic SF2768	Streptomyces thioluteus
BGC0001345.1	0.34	NRP	myxochelin A, myxochelin B	Stigmatella aurantiaca Sg a15
BGC0001399.1	0.30	NRP	fellutamide B	Aspergillus nidulans FGSC A4
BGC0001637.1	0.27	NRP	kleboxymycin	Klebsiella oxytoca
BGC0001903.1	0.27	Other	neocarazostatin A	Streptomyces sp. MA37
BGC0001724.1	0.24	NRP, Polyketide	oxaleimide C	Penicillium oxalicum 114-2
BGC0001805.1	0.24	NRP	tilivalline	Klebsiella oxytoca
BGC0000446.1	0.24	NRP	tilivalline, 9-deoxy tilivalline, dihydroxy tilivalline, dehydro tilivalline, dihydroxy-dehydro tilivalline	Klebsiella oxytoca
BGC0000286.1	0.23	Polyketide	viguiepinol	Streptomyces sp. KO-3988
BGC0000343.1	0.23	NRP	enterobactin	Pseudomonas sp. J465

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001574.1	0.99	NRP	diisonitrile antibiotic SF2768	Streptomyces thioluteus
BGC0001345.1	0.67	NRP	myxochelin A, myxochelin B	Stigmatella aurantiaca Sg a15
BGC0001399.1	0.64	NRP	fellutamide B	Aspergillus nidulans FGSC A4
BGC0001637.1	0.61	NRP	kleboxymycin	Klebsiella oxytoca
BGC0001903.1	0.61	Other	neocarazostatin A	Streptomyces sp. MA37
BGC0001724.1	0.58	NRP, Polyketide	oxaleimide C	Penicillium oxalicum 114-2
BGC0001805.1	0.57	NRP	tilivalline	Klebsiella oxytoca
BGC0000446.1	0.57	NRP	tilivalline, 9-deoxy tilivalline, dihydroxy tilivalline, dehydro tilivalline, dihydroxy-dehydro tilivalline	Klebsiella oxytoca
BGC0000286.1	0.56	Polyketide	viguiepinol	Streptomyces sp. KO-3988
BGC0000343.1	0.56	NRP	enterobactin	Pseudomonas sp. J465

Similar known gene clusters

Module view

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NRPS/PKS products

NRPS/PKS monomers

Predicted core structure(s)

For candidate cluster 1, location 0 - 24094:

Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:: (X)

Direct lookup in NORINE database: strict or relaxed

Link to NORINE database query form

NRPS/PKS monomer predictions

ATY72527.1

Search NORINE for peptide: strict or relaxed

AMP-binding (28..427): X

NRPSPredictor2: (unknown)

SVM prediction details:

NOTE: outside applicability domain

Predicted physicochemical class:: hydrophobic-aliphatic
Large clusters prediction:: N/A
Small clusters prediction:: N/A
Single AA prediction:: N/A

Stachelhaus prediction details:

Stachelhaus sequence:: hvWcVGintK
Nearest Stachelhaus code:: thr
Stachelhaus code match:: 40% (weak)

ATY72525.1

Search NORINE for peptide: strict or relaxed

AMP-binding (458..842): X

NRPSPredictor2: asp, asn, glu, gln, aad

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic
Large clusters prediction:: asp, asn, glu, gln, aad
Small clusters prediction:: N/A
Single AA prediction:: N/A

Stachelhaus prediction details:

Stachelhaus sequence:: DaEdVGTvVK
Nearest Stachelhaus code:: lys-b
Stachelhaus code match:: 70% (weak)