BGC0002081: streptoketide A biosynthetic gene cluster from Streptomyces sp. Tue6314
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Location: 5,927 - 26,330 nt. (total: 20,404 nt).
This entry is originally from NCBI GenBank MK424349.1.

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core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
TTA codons
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Gene details
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General
Compounds
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Biosynthesis
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NRPS/PKS domains
KnownClusterBlast
General information about the BGC
MIBiG accession BGC0002081
Short description streptoketide A biosynthetic gene cluster from Streptomyces sp. Tue6314
Status Quality: questionable
The quality level of this entry.

Status: active
The status of this entry.

Completeness: complete
Whether the entry covers everything needed for the pathway producing the compound(s)
Biosynthetic class(es)
  • PKS (Unknown)
Loci
MK424349.1
5927 - 26330
via Heterologous expression
Compounds
  • streptoketide A
  • streptoketide B
  • streptoketide C
  • S2502
  • S2507
  • UWM5
Species Streptomyces sp. Tue6314 [taxonomy]
References
Chemical products information
streptoketide A Evidence: NMR
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Chemical database entries
NPAtlas
streptoketide B Evidence: NMR
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Chemical database entries
NPAtlas
streptoketide C Evidence: NMR
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S2502 Evidence: NMR
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S2507 Evidence: NMR
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UWM5 Evidence: NMR
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List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Extra
  • QED90611.1
 5928 - 6173 (-) acyl carrier protein
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    • QED90612.1
    		 6212 - 7480 (-) ketosynthase chain-length factor
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      • QED90637.1
      		 7477 - 8748 (-) beta-ketoacyl-[acyl-carrier-protein] synthase family protein
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        • QED90613.1
        		 9095 - 9598 (+) MarR family transcriptional regulator
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          • QED90614.1
          		 9682 - 10137 (+) putative cyclase
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            • QED90615.1
            		 10197 - 11003 (-) SARP family transcriptional regulator
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              • QED90616.1
              		 11283 - 12839 (-) cholesterol oxidase
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                • QED90617.1
                		 12979 - 13653 (-) SAM-dependent methyltransferase
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                  • QED90618.1
                  		 13900 - 14703 (+) ketoacyl reductase
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                    • QED90619.1
                    		 14736 - 15779 (+) putative cyclase
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                      • QED90620.1
                      		 15772 - 17619 (+) AMP-dependent ligase
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                        • QED90621.1
                        		 17609 - 18349 (+) short-chain dehydrogenase/reductase SDR
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                          • QED90622.1
                          		 18373 - 19164 (+) short-chain dehydrogenase
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                            • QED90623.1
                            		 19175 - 20428 (+) FAD-binding monooxygenase
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                              • QED90624.1
                              		 20425 - 21198 (+) putative cyclase
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                                • QED90625.1
                                		 21371 - 22357 (+) aldo/keto reductase
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                                  • QED90626.1
                                  		 22443 - 23474 (-) 3-oxoacyl-ACP synthase III
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                                    • QED90627.1
                                    		 23649 - 24650 (+) acyltransferase domain-containing protein
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                                      • QED90628.1
                                      		 24720 - 26330 (+) methylmalonyl-CoA carboxyltransferase
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                                        Biosynthesis information
                                        Annotation changelog

                                        Entry version: 2

                                        Date
                                        Changes
                                        Submitters
                                        Reviewers
                                        2022-10-07
                                        Update chemical activity to schema version 2.11
                                        • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                        • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                        2022-10-07
                                        Changed chemical structures for compounds: streptoketide A, streptoketide B.
                                        • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                        • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                                        Entry version: 1

                                        Date
                                        Changes
                                        Submitters
                                        Reviewers
                                        2022-09-15
                                        Submitted
                                        • (ID: ZA5Z4HT5MOJPYYEQY2X7STLX)
                                        • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                        2022-09-15
                                        Remove negative ketide_length
                                        • (ID: 3UOU7PODQJXIM6BEPUHHRRA5)
                                        • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                        2022-09-15
                                        Added version to NCBI accession
                                        • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                        • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                        Detailed domain annotation
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