BGC0002081 - 1 region(s) - antiSMASH results

Identified secondary metabolite regions using strictness 'relaxed'

BGC0002081 (Streptomyces sp. Tue6314)

Region	Type	From	To	Most similar known cluster		Similarity
Region 1	PKS-like,T2PKS	1	20,404	streptoketide A/streptoketide B/streptoketide C/S2502/S2507/UWM5	PKS	100%

BGC0002081 - Region 1 - PKS-like,T2PKS

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Location: 1 - 20,404 nt. (total: 20,404 nt) Show pHMM detection rules used

Region on contig edge.

PKS-like: (t2pks2 or ksIII)
T2PKS: (t2ks and t2clf)

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core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

TTA codons

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Gene details

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Gene overview

MIBiG

NRPS/PKS domains

MIBiG comparison

KnownClusterBlast

Gene/CDS overview

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Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

External annotation

Name		MIBiG
Version		4.0alpha

Type		Subregion
Location		1 - 20,405
Label		BGC0002081

Detailed domain annotation

Selected features only

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Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002081	2.00	Polyketide	streptoketide A, streptoketide B, streptoketide C, S2502, S2507, UWM5	Streptomyces sp. Tue6314
BGC0000231	0.86	Polyketide	griseusin A, griseusin B	Streptomyces griseus
BGC0000234	0.62	Polyketide	jadomycin	Streptomyces venezuelae ATCC 10712
BGC0000196	0.56	Polyketide	AQ-256, AQ-270a, AQ-284a	Photorhabdus laumondii subsp. laumondii TTO1
BGC0001723	0.56	Polyketide	oviedomycin	Streptomyces antibioticus
BGC0000272	0.55	Polyketide	spore pigment	Streptomyces collinus
BGC0000252	0.50	Polyketide	nonactin	Streptomyces griseus subsp. griseus
BGC0000866	0.50	Other	polyhydroxyalkanoate	Burkholderia sp. DSM 9242
BGC0000218	0.48	Polyketide	doxorubicin	Streptomyces peucetius
BGC0000275	0.48	Polyketide	tetracenomycin C	Streptomyces glaucescens

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002081	1.00	Polyketide	streptoketide A, streptoketide B, streptoketide C, S2502, S2507, UWM5	Streptomyces sp. Tue6314
BGC0000231	0.74	Polyketide	griseusin A, griseusin B	Streptomyces griseus
BGC0000234	0.64	Polyketide	jadomycin	Streptomyces venezuelae ATCC 10712
BGC0000196	0.61	Polyketide	AQ-256, AQ-270a, AQ-284a	Photorhabdus laumondii subsp. laumondii TTO1
BGC0001723	0.61	Polyketide	oviedomycin	Streptomyces antibioticus
BGC0000272	0.61	Polyketide	spore pigment	Streptomyces collinus
BGC0000252	0.58	Polyketide	nonactin	Streptomyces griseus subsp. griseus
BGC0000866	0.58	Other	polyhydroxyalkanoate	Burkholderia sp. DSM 9242
BGC0000218	0.57	Polyketide	doxorubicin	Streptomyces peucetius
BGC0000275	0.57	Polyketide	tetracenomycin C	Streptomyces glaucescens

Similar known gene clusters from MIBiG 4.0

NRPS/PKS substrates

Type II PKS

NRPS/PKS substrate predictions

QED90620.1

AMP-binding (16..415): X

nrpys: Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
Large clusters prediction:: N/A
Small clusters prediction:: N/A
Single AA prediction:: N/A

Stachelhaus prediction details:

Stachelhaus sequence:: PMNYAGGPLK
Nearest Stachelhaus code(s):
Stachelhaus code match:: 0% (weak)

QED90627.1

PKS_AT (18..296): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 62.5%; inactive: 58.3%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 52.1
Methylmalonyl-CoA: 32.2
Propionyl-CoA: 20.0
inactive: 19.9
Methoxymalonyl-CoA: 16.8
trans-1,2-CPDA: 0.0
fatty_acid: 0.0
Isobutyryl-CoA: 0.0
Ethylmalonyl-CoA: 0.0
CHC-CoA: 0.0
Benzoyl-CoA: 0.0
Acetyl-CoA: 0.0
3-Methylbutyryl-CoA: 0.0
2-Methylbutyryl-CoA: 0.0

Type II PKS gene cluster prediction details

Cluster section:: 0 to 20404
Starter unit(s):: propionyl-CoA (Score: 716.0; E-value: 3.7e-133)
malonamyl-CoA (Score: 478.0; E-value: 1.38e-165)
Malonyl elongations:: 8|9 (Score: 575.8; E-value: 9.1e-176)
Product class(es):: anthracycline
aureolic acid
tetracycline
Product molecular weight(s):: malonamyl-CoA_8: 382 Da
malonamyl-CoA_9: 424 Da
propionyl-CoA_8: 353 Da
propionyl-CoA_9: 395 Da

QED90611.1: ACP (Score: 120.5; E-value: 5.2e-38)
QED90612.1: CLF 8|9 (Score: 575.8; E-value: 9.1e-176)
QED90614.1: CYC C1-C18|C2-C19 (Score: 188.2; E-value: 1.4e-58)
QED90618.1: KR C9 (Score: 448.7; E-value: 1.3e-137)
QED90619.1: CYC C7-C12 (Score: 420.2; E-value: 8.8e-129)
QED90620.1: LIG (Score: 537.5; E-value: 6.1e-164); LIG ELQ83297.1_Oxytetracycline_malonamyl-CoA (Score: 478.0; E-value: 1.38e-165)
QED90621.1: KR (Score: 111.2; E-value: 1.5e-34)
QED90622.1: KR (Score: 118.9; E-value: 7.2e-37)
QED90623.1: OXY (Score: 178.2; E-value: 7.1e-55)
QED90624.1: CYC C5-C14/C3-C16 (Score: 409.9; E-value: 9.7e-126)
QED90625.1: KR (Score: 85.1; E-value: 1.5e-26)
QED90626.1: KSIII (Score: 428.1; E-value: 5.3e-131); KSIII ABC00733.1_Cosmomycin_propionyl-CoA (Score: 374.0; E-value: 3.7e-133)
QED90627.1: AT (Score: 412.7; E-value: 2.5e-126); AT BAB72049.1_Aklavinone_propionyl-CoA (Score: 342.0; E-value: 1.66e-120)
QED90637.1: KS (Score: 733.6; E-value: 1.4e-223)