BGC0002196 - 1 region(s) - antiSMASH results

Identified secondary metabolite regions using strictness 'relaxed'

BGC0002196 (Penicillium crustosum)

Region	Type	From	To	Similarity Confidence	Most similar known cluster
Region 1	T1PKS	1	36,246	High	clavatol	PKS

BGC0002196 - Region 1 - T1PKS

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Location: 1 - 36,246 nt. (total: 36,246 nt) Show pHMM detection rules used

Region on contig edge.

T1PKS: cds(PKS_AT and (PKS_KS or ene_KS or mod_KS or hyb_KS or itr_KS or tra_KS))

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core biosynthetic genes

additional biosynthetic genes

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Gene details

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Gene overview

MIBiG

Tailoring

MIBiG comparison

KnownClusterBlast

NRPS/PKS modules

NRPS/PKS domains

Gene/CDS overview

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Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

External annotation

Name		MIBiG
Version		4.0alpha

Type		Subregion
Location		1 - 36,247
Label		BGC0002196

Tailoring functions

Oxidoreductases: oxygenase

QBK15048.1: cytochrome P450

smcogs: SMCOG1034: cytochrome P450

Lyases: hydratase

QBK15041.1: enoyl-CoA hydratase

smcogs: SMCOG1023: enoyl-CoA hydratase

Ligases: synthase

QBK15044.1: Beta-ketoacyl synthase

smcogs: SMCOG1022: Beta-ketoacyl synthase

QBK15047.1: Beta-ketoacyl synthase

smcogs: SMCOG1022: Beta-ketoacyl synthase

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002196.2	1.00	PKS	clavatol	Penicillium crustosum
BGC0002191.2	0.67	PKS	prolipyrone B, gibepyrone D	Fusarium graminearum PH-1
BGC0001284.4	0.66	PKS	alternariol	Parastagonospora nodorum SN15
BGC0001273.3	0.66	PKS	asperlactone	Aspergillus ochraceus
BGC0001244.3	0.66	PKS	(-)-Mellein	Parastagonospora nodorum
BGC0001276.3	0.66	PKS	6-methylsalicyclic acid	Aspergillus terreus
BGC0002192.3	0.64	PKS	FR901512	fungal sp. No.14919
BGC0000037.4	0.64	PKS	cichorine	Aspergillus nidulans FGSC A4
BGC0000107.3	0.63	PKS	naphthopyrone	Aspergillus nidulans FGSC A4
BGC0001254.3	0.63	PKS	ACT-Toxin II	Alternaria alternata

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002196.2	1.00	PKS	clavatol	Penicillium crustosum
BGC0002191.2	0.67	PKS	prolipyrone B, gibepyrone D	Fusarium graminearum PH-1
BGC0001284.4	0.66	PKS	alternariol	Parastagonospora nodorum SN15
BGC0001273.3	0.66	PKS	asperlactone	Aspergillus ochraceus
BGC0001244.3	0.66	PKS	(-)-Mellein	Parastagonospora nodorum
BGC0001276.3	0.66	PKS	6-methylsalicyclic acid	Aspergillus terreus
BGC0002192.3	0.64	PKS	FR901512	fungal sp. No.14919
BGC0000037.4	0.64	PKS	cichorine	Aspergillus nidulans FGSC A4
BGC0000107.3	0.63	PKS	naphthopyrone	Aspergillus nidulans FGSC A4
BGC0001254.3	0.63	PKS	ACT-Toxin II	Alternaria alternata

Similar known clusters from MIBiG 4.0

Module view

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Detailed domain annotation

Selected features only

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NRPS/PKS products

NRPS/PKS substrates

Predicted core structure(s)

For candidate cluster 1, location 0 - 36246:

Rough prediction of core scaffold based on assumed PKS linker matching; tailoring reactions not taken into account

Polymer prediction:: (pk) + (pk)
Non-colinear ordering:: QBK15047.1 + QBK15044.1

Direct lookup in NORINE database: strict or relaxed

Link to NORINE database query form

NRPS/PKS substrate predictions

QBK15044.1: pk

PKS_AT (911..1201): pk

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 62.5%; Ethylmalonyl-CoA: 54.2%; Methylmalonyl-CoA: 54.2%

minowa: Methoxymalonyl-CoA

Prediction, score:

Methoxymalonyl-CoA: 56.1
Malonyl-CoA: 54.6
Methylmalonyl-CoA: 49.6
inactive: 49.5
Propionyl-CoA: 40.1
CHC-CoA: 32.0
Ethylmalonyl-CoA: 30.7
2-Methylbutyryl-CoA: 25.7
trans-1,2-CPDA: 25.3
fatty_acid: 17.1
Benzoyl-CoA: 8.6
Isobutyryl-CoA: 0.0
Acetyl-CoA: 0.0
3-Methylbutyryl-CoA: 0.0

QBK15047.1: pk

PKS_AT (529..841): pk

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 75.0%; Methylmalonyl-CoA: 70.8%; Ethylmalonyl-CoA: 62.5%

minowa: Methoxymalonyl-CoA

Prediction, score:

Methoxymalonyl-CoA: 51.6
Methylmalonyl-CoA: 50.7
Malonyl-CoA: 28.7
Propionyl-CoA: 27.6
Isobutyryl-CoA: 16.3
fatty_acid: 12.1
Benzoyl-CoA: 10.8
Ethylmalonyl-CoA: 10.0
trans-1,2-CPDA: 0.0
inactive: 0.0
CHC-CoA: 0.0
Acetyl-CoA: 0.0
3-Methylbutyryl-CoA: 0.0
2-Methylbutyryl-CoA: 0.0

Link to PARAS substrate predictor