BGC0002208 - 1 region(s) - antiSMASH results

Identified secondary metabolite regions using strictness 'relaxed'

BGC0002208 (Aspergillus ustus)

Region	Type	From	To	Most similar known cluster		Similarity
Region 1	NRPS	1	30,253	oxepinamide F	NRPS:Type I	100%

BGC0002208 - Region 1 - NRPS

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Location: 1 - 30,253 nt. (total: 30,253 nt) Show pHMM detection rules used

Region on contig edge.

NRPS: cds(Condensation and (AMP-binding or A-OX))

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core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

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Gene details

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Gene overview

MIBiG

NRPS/PKS domains

MIBiG comparison

KnownClusterBlast

NRPS/PKS modules

Gene/CDS overview

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Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

External annotation

Name		MIBiG
Version		4.0alpha

Type		Subregion
Location		1 - 30,254
Label		BGC0002208

Detailed domain annotation

Selected features only

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Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002208	1.00	NRP	oxepinamide F	Aspergillus ustus
BGC0002157	0.33	NRP, Alkaloid	(-)-ditryptophenaline	Aspergillus flavus
BGC0001261	0.29	NRP	AM-toxin	Alternaria alternata
BGC0000404	0.28	NRP	penicillin	Penicillium chrysogenum
BGC0002272	0.27	NRP	asterrelenin, epi-aszonalenin A	Aspergillus terreus NIH2624
BGC0000348	0.27	NRP	ergovaline	Epichloe festucae var. lolii
BGC0001240	0.26	NRP	serinocyclin A, serinocyclin B	Metarhizium robertsii
BGC0000357	0.26	NRP	cyclo-(D-Phe-L-Phe-D-Val-L-Val), cyclo-(D-Tyr-L-Phe-D-Val-L-Val), cyclo-(D-Tyr-L-Trp-D-Val-L-Val), cyclo-(D-Phe-L-Trp-D-Val-L-Val), cyclo-(D-Phe-L-Phe-D-Val-L-Ile), cyclo-(D-Phe-L-Phe-D-Ile-L-Val), cyclo-(D-Tyr-L-Trp-D-Val-L-Ile), cyclo-(D-Tyr-L-Trp-D-Ile-L-Val), cyclo-(D-Tyr-L-Phe-D-Val-L-Ile), cyclo-(D-Tyr-L-Phe-D-Ile-L-Val)	Penicillium rubens Wisconsin 54-1255
BGC0002242	0.26	NRP	oxepinamide D	Aspergillus ustus
BGC0001132	0.26	NRP	xenotetrapeptide	Xenorhabdus nematophila ATCC 19061

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002208	1.00	NRP	oxepinamide F	Aspergillus ustus
BGC0002157	0.66	NRP, Alkaloid	(-)-ditryptophenaline	Aspergillus flavus
BGC0001261	0.63	NRP	AM-toxin	Alternaria alternata
BGC0000404	0.61	NRP	penicillin	Penicillium chrysogenum
BGC0002272	0.61	NRP	asterrelenin, epi-aszonalenin A	Aspergillus terreus NIH2624
BGC0000348	0.61	NRP	ergovaline	Epichloe festucae var. lolii
BGC0001240	0.60	NRP	serinocyclin A, serinocyclin B	Metarhizium robertsii
BGC0000357	0.60	NRP	cyclo-(D-Phe-L-Phe-D-Val-L-Val), cyclo-(D-Tyr-L-Phe-D-Val-L-Val), cyclo-(D-Tyr-L-Trp-D-Val-L-Val), cyclo-(D-Phe-L-Trp-D-Val-L-Val), cyclo-(D-Phe-L-Phe-D-Val-L-Ile), cyclo-(D-Phe-L-Phe-D-Ile-L-Val), cyclo-(D-Tyr-L-Trp-D-Val-L-Ile), cyclo-(D-Tyr-L-Trp-D-Ile-L-Val), cyclo-(D-Tyr-L-Phe-D-Val-L-Ile), cyclo-(D-Tyr-L-Phe-D-Ile-L-Val)	Penicillium rubens Wisconsin 54-1255
BGC0002242	0.60	NRP	oxepinamide D	Aspergillus ustus
BGC0001132	0.59	NRP	xenotetrapeptide	Xenorhabdus nematophila ATCC 19061

Similar known gene clusters from MIBiG 4.0

Module view

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NRPS/PKS products

NRPS/PKS substrates

Predicted core structure(s)

For candidate cluster 1, location 0 - 30253:

Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:: (X - D-X - Leu)

Direct lookup in NORINE database: strict or relaxed

Link to NORINE database query form

NRPS/PKS substrate predictions

HK57_00065

Search NORINE for peptide: strict or relaxed

AMP-binding (247..641): X

nrpys: (unknown)

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
Large clusters prediction:: Apolar, aliphatic (Gly, Ala, Val, Leu, Ile, Abu, Ival)
Small clusters prediction:: N/A
Single AA prediction:: N/A

Stachelhaus prediction details:

Stachelhaus sequence:: GMIILAAGIK
Nearest Stachelhaus code(s):: 4clBza or 2clBza GVIILAAGIK (71% 8Å match)
Stachelhaus code match:: 90% (moderate)

AMP-binding (1327..1725): X

nrpys: (unknown)

SVM prediction details:

Predicted physicochemical class:: N/A
Large clusters prediction:: N/A
Small clusters prediction:: N/A
Single AA prediction:: N/A

Stachelhaus prediction details:

Stachelhaus sequence:: DAAIAVGPAK
Nearest Stachelhaus code(s):: Gln or Glu DAAILVGVGK (47% 8Å match)
Stachelhaus code match:: 70% (weak)

AMP-binding (2845..3243): Leu

nrpys: Leu

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
Large clusters prediction:: Apolar, aliphatic (Gly, Ala, Val, Leu, Ile, Abu, Ival)
Small clusters prediction:: Aliphatic, branched hydrophobic (Val, Leu, Ile, Abu, Ival)
Single AA prediction:: leu (Leu)

Stachelhaus prediction details:

Stachelhaus sequence:: DAFFVGAVFK
Nearest Stachelhaus code(s):: Leu DALFVGAVAK (62% 8Å match); Leu or Ile DAFFNGAVYK (47% 8Å match)
Stachelhaus code match:: 80% (moderate)