BGC0002478 - 1 region(s) - antiSMASH results

Identified secondary metabolite regions using strictness 'relaxed'

BGC0002478 (Streptomyces sp. CB02414)

Region	Type	From	To	Similarity Confidence	Most similar known cluster
Region 1	T2PKS	1	72,492	High	rubiginone A2/rubiginone J/rubiginone K/rubiginone L/rubiginone M/rubiginone N/ochromycinone/rubiginone B2	PKS

BGC0002478 - Region 1 - T2PKS

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Location: 1 - 72,492 nt. (total: 72,492 nt) Show pHMM detection rules used

Region on contig edge.

T2PKS: (t2ks and t2clf)

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core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

TTA codons

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Gene details

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Gene overview

MIBiG

Tailoring

MIBiG comparison

KnownClusterBlast

NRPS/PKS domains

Gene/CDS overview

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Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

External annotation

Name		MIBiG
Version		4.0alpha

Type		Subregion
Location		1 - 72,493
Label		BGC0002478

Tailoring functions

Oxidoreductases: dehydrogenase oxidoreductase oxygenase

AMK11_25545: short-chain dehydrogenase/reductase SDR

smcogs: SMCOG1001: short-chain dehydrogenase/reductase SDR

AMK11_25555: monooxygenase FAD-binding

smcogs: SMCOG1050: monooxygenase FAD-binding

AMK11_25580: short-chain dehydrogenase/reductase SDR

smcogs: SMCOG1001: short-chain dehydrogenase/reductase SDR

AMK11_25590: monooxygenase FAD-binding

smcogs: SMCOG1050: monooxygenase FAD-binding

AMK11_25595: short-chain dehydrogenase/reductase SDR

smcogs: SMCOG1001: short-chain dehydrogenase/reductase SDR

AMK11_25610: oxidoreductase

smcogs: SMCOG1083: oxidoreductase

AMK11_25640: short-chain dehydrogenase/reductase SDR

smcogs: SMCOG1001: short-chain dehydrogenase/reductase SDR

AMK11_25645: cytochrome P450

smcogs: SMCOG1007: cytochrome P450

AMK11_25675: monooxygenase FAD-binding

smcogs: SMCOG1246: monooxygenase FAD-binding

AMK11_25705: cytochrome P450

smcogs: SMCOG1007: cytochrome P450

Transferases: acyltransferase carboxylase methyltransferase transferase

AMK11_25600: acetyl-CoA carboxylase, carboxyl transferase,

smcogs: SMCOG1059: acetyl-CoA carboxylase, carboxyl transferase,

AMK11_25650: methyltransferase

smcogs: SMCOG1089: methyltransferase

AMK11_25695: acyltransferase 3

smcogs: SMCOG1088: acyltransferase 3

AMK11_25720: O-methyltransferase

smcogs: SMCOG1042: O-methyltransferase

AMK11_25725: acetyl-CoA carboxylase biotin carboxylase

smcogs: SMCOG1090: acetyl-CoA carboxylase biotin carboxylase

Hydrolases: hydrolase

AMK11_25655: alpha/beta hydrolase fold protein

smcogs: SMCOG1036: alpha/beta hydrolase fold protein

Lyases: cyclase

AMK11_25560: Polyketide synthesis cyclase

smcogs: SMCOG1225: Polyketide synthesis cyclase

AMK11_25585: cyclase/dehydrase

smcogs: SMCOG1128: cyclase/dehydrase

Ligases: synthase

AMK11_25565: Beta-ketoacyl synthase

smcogs: SMCOG1022: Beta-ketoacyl synthase

AMK11_25570: Beta-ketoacyl synthase

smcogs: SMCOG1093: Beta-ketoacyl synthase

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002478.3	1.00	PKS	rubiginone A2, rubiginone J, rubiginone K, rubiginone L, rubiginone M, rubiginone N, ochromycinone, rubiginone B2	Streptomyces sp. CB02414
BGC0000231.5	0.82	PKS	griseusin A, griseusin B	Streptomyces griseus
BGC0001723.5	0.77	PKS	oviedomycin	Streptomyces antibioticus
BGC0000234.5	0.73	PKS	jadomycin	Streptomyces venezuelae ATCC 10712
BGC0000235.5	0.62	PKS	kiamycin	Streptomyces sp. W007
BGC0000272.3	0.60	PKS	spore pigment	Streptomyces collinus
BGC0000236.5	0.60	PKS	kinamycin	Streptomyces murayamaensis
BGC0001895.4	0.60	PKS	huanglongmycin A, huanglongmycin B, huanglongmycin C	Streptomyces sp. CB09001
BGC0002504.2	0.57	PKS	nocardiopsistin A, nocardiopsistin B, nocardiopsistin C	Nocardiopsis sp.
BGC0002084.4	0.57	ribosomal	biarylitide YYH	Planomonospora sp. ID82291

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002478.3	1.00	PKS	rubiginone A2, rubiginone J, rubiginone K, rubiginone L, rubiginone M, rubiginone N, ochromycinone, rubiginone B2	Streptomyces sp. CB02414
BGC0000231.5	0.82	PKS	griseusin A, griseusin B	Streptomyces griseus
BGC0001723.5	0.77	PKS	oviedomycin	Streptomyces antibioticus
BGC0000234.5	0.73	PKS	jadomycin	Streptomyces venezuelae ATCC 10712
BGC0000235.5	0.62	PKS	kiamycin	Streptomyces sp. W007
BGC0000272.3	0.60	PKS	spore pigment	Streptomyces collinus
BGC0000236.5	0.60	PKS	kinamycin	Streptomyces murayamaensis
BGC0001895.4	0.60	PKS	huanglongmycin A, huanglongmycin B, huanglongmycin C	Streptomyces sp. CB09001
BGC0002504.2	0.57	PKS	nocardiopsistin A, nocardiopsistin B, nocardiopsistin C	Nocardiopsis sp.
BGC0002084.4	0.57	ribosomal	biarylitide YYH	Planomonospora sp. ID82291

Similar known clusters from MIBiG 4.0

Detailed domain annotation

Selected features only

Show module domains

Type II PKS

Type II PKS gene cluster prediction details

Cluster section:: 0 to 72492
Starter unit(s):: acetyl-CoA (Score: 0.0; E-value: 0)
Malonyl elongations:: 8|9 (Score: 709.3; E-value: 2.6e-216)
Product class(es):: angucycline
Product molecular weight(s):: acetyl-CoA_8: 399 Da
acetyl-CoA_9: 441 Da

AMK11_25545: KR (Score: 84.2; E-value: 2.7e-26)
AMK11_25555: OXY (Score: 564.1; E-value: 6.2e-172)
AMK11_25560: CYC C4-C17/C2-C19 (Score: 198.7; E-value: 2.1e-61)
AMK11_25565: KS (Score: 785.3; E-value: 2.8e-239)
AMK11_25570: CLF 8|9 (Score: 709.3; E-value: 2.6e-216)
AMK11_25575: ACP (Score: 100.0; E-value: 1.4e-31)
AMK11_25580: KR C9 (Score: 486.6; E-value: 3.9e-149)
AMK11_25585: CYC C7-C12 (Score: 483.4; E-value: 5.4e-148)
AMK11_25590: OXY (Score: 567.1; E-value: 7.7e-173)
AMK11_25595: KR (Score: 152.4; E-value: 4.3e-47)
AMK11_25650: MET (Score: 37.1; E-value: 4.4e-12)
AMK11_25720: MET C2O|C2N (Score: 316.9; E-value: 3.5e-97)