BGC0000031 - 1 region(s) - antiSMASH results

Identified secondary metabolite regions using strictness 'relaxed'

BGC0000031 (Streptomyces parvulus)

Region	Type	From	To	Most similar known cluster		Similarity
Region 1	T1PKS	1	74,787	borrelidin	Polyketide	97%

BGC0000031 - Region 1 - T1PKS

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Location: 1 - 74,787 nt. (total: 74,787 nt) Show pHMM detection rules used

Region on contig edge.

T1PKS: cds(PKS_AT and (PKS_KS or ene_KS or mod_KS or hyb_KS or itr_KS or tra_KS))

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core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

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TTA codons

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Gene details

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MIBiG

NRPS/PKS domains

MIBiG comparison

KnownClusterBlast

NRPS/PKS modules

External annotation

Name		MIBiG
Version		3.0

Type		Subregion
Location		1 - 74,788
Label		BGC0000031

Detailed domain annotation

Selected features only

Show module domains

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000031.1	0.74	Polyketide	borrelidin	Streptomyces parvulus
BGC0001533.1	0.68	Polyketide	borrelidin	Streptomyces rochei
BGC0000018.1	0.31	Polyketide	angolamycin	Streptomyces eurythermus
BGC0000068.1	0.30	Polyketide	geldanamycin	Streptomyces hygroscopicus
BGC0001276.1	0.30	Polyketide	6-methylsalicyclic acid	Aspergillus terreus
BGC0001275.1	0.30	Polyketide	6-methylsalicyclic acid	Glarea lozoyensis
BGC0001273.1	0.30	Polyketide	asperlactone	Aspergillus ochraceus
BGC0001244.1	0.30	Polyketide	(-)-Mellein	Parastagonospora nodorum
BGC0001858.1	0.29	Polyketide	alternapyrone B, alternapyrone C, alternapyrone D, alternapyrone E, alternapyrone F	Parastagonospora nodorum SN15
BGC0000041.1	0.29	Polyketide	oronofacic acid	Pseudomonas syringae

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000031.1	0.92	Polyketide	borrelidin	Streptomyces parvulus
BGC0001533.1	0.88	Polyketide	borrelidin	Streptomyces rochei
BGC0000018.1	0.64	Polyketide	angolamycin	Streptomyces eurythermus
BGC0000068.1	0.64	Polyketide	geldanamycin	Streptomyces hygroscopicus
BGC0001276.1	0.64	Polyketide	6-methylsalicyclic acid	Aspergillus terreus
BGC0001275.1	0.64	Polyketide	6-methylsalicyclic acid	Glarea lozoyensis
BGC0001273.1	0.64	Polyketide	asperlactone	Aspergillus ochraceus
BGC0001244.1	0.63	Polyketide	(-)-Mellein	Parastagonospora nodorum
BGC0001858.1	0.62	Polyketide	alternapyrone B, alternapyrone C, alternapyrone D, alternapyrone E, alternapyrone F	Parastagonospora nodorum SN15
BGC0000041.1	0.62	Polyketide	oronofacic acid	Pseudomonas syringae

Similar known gene clusters

Module view

Legend

NRPS/PKS products

NRPS/PKS monomers

Predicted core structure(s)

For candidate cluster 1, location 0 - 70742:

Rough prediction of core scaffold based on assumed PKS linker matching; tailoring reactions not taken into account

Polymer prediction:: (pk) + (ohmal) + (ccmal - Me-ccmal) + (Me-ohmal) + (Me-redmal) + (ohmal)
Non-colinear ordering:: borA1 + borA2 + borA3 + borA4 + borA5 + borA6

Direct lookup in NORINE database: strict or relaxed

Link to NORINE database query form

NRPS/PKS monomer predictions

borA1

PKS_AT (323..622): pk

ATSignature: trans-1,2-CPDA

Top 3 matches:: trans-1,2-CPDA: 100.0%; Ethylmalonyl-CoA: 83.3%; Methoxymalonyl-CoA: 83.3%

minowa: trans-1,2-CPDA

Prediction, score:

trans-1,2-CPDA: 290.9
Ethylmalonyl-CoA: 173.8
Methylmalonyl-CoA: 166.7
Methoxymalonyl-CoA: 150.6
2-Methylbutyryl-CoA: 116.2
Propionyl-CoA: 103.8
CHC-CoA: 91.7
Malonyl-CoA: 65.2
Acetyl-CoA: 56.6
Benzoyl-CoA: 54.1
Isobutyryl-CoA: 52.5
fatty_acid: 31.6
3-Methylbutyryl-CoA: 30.1
inactive: 14.2

borA2

PKS_AT (558..844): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 100.0%; inactive: 75.0%; Methylmalonyl-CoA: 54.2%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 197.9
inactive: 95.6
Methoxymalonyl-CoA: 56.6
Propionyl-CoA: 38.1
Methylmalonyl-CoA: 37.7
Isobutyryl-CoA: 18.7
fatty_acid: 14.4
Ethylmalonyl-CoA: 14.2
Acetyl-CoA: 10.8
Benzoyl-CoA: 7.3
trans-1,2-CPDA: 6.2
CHC-CoA: 0.0
3-Methylbutyryl-CoA: 0.0
2-Methylbutyryl-CoA: 0.0

borA3

PKS_AT (560..846): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 100.0%; inactive: 75.0%; Methylmalonyl-CoA: 54.2%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 199.3
inactive: 95.6
Methoxymalonyl-CoA: 57.2
Propionyl-CoA: 39.0
Methylmalonyl-CoA: 38.8
Isobutyryl-CoA: 19.3
fatty_acid: 14.4
Ethylmalonyl-CoA: 14.2
Acetyl-CoA: 10.8
Benzoyl-CoA: 7.3
trans-1,2-CPDA: 6.4
CHC-CoA: 0.0
3-Methylbutyryl-CoA: 0.0
2-Methylbutyryl-CoA: 0.0

PKS_AT (2246..2535): mmal

ATSignature: Methylmalonyl-CoA

Top 3 matches:: Methylmalonyl-CoA: 100.0%; Methoxymalonyl-CoA: 91.7%; Ethylmalonyl-CoA: 87.5%

minowa: Methylmalonyl-CoA

Prediction, score:

Methylmalonyl-CoA: 199.6
Ethylmalonyl-CoA: 184.3
Methoxymalonyl-CoA: 160.9
2-Methylbutyryl-CoA: 128.6
Propionyl-CoA: 111.1
trans-1,2-CPDA: 109.9
CHC-CoA: 98.7
Malonyl-CoA: 94.2
Isobutyryl-CoA: 69.4
Benzoyl-CoA: 68.0
Acetyl-CoA: 56.0
3-Methylbutyryl-CoA: 43.0
inactive: 35.2
fatty_acid: 28.9

borA4

PKS_AT (543..832): mmal

ATSignature: Methylmalonyl-CoA

Top 3 matches:: Methylmalonyl-CoA: 100.0%; Methoxymalonyl-CoA: 91.7%; Ethylmalonyl-CoA: 87.5%

minowa: Methylmalonyl-CoA

Prediction, score:

Methylmalonyl-CoA: 199.6
Ethylmalonyl-CoA: 184.3
Methoxymalonyl-CoA: 160.9
2-Methylbutyryl-CoA: 128.6
Propionyl-CoA: 111.1
trans-1,2-CPDA: 109.9
CHC-CoA: 98.7
Malonyl-CoA: 94.2
Isobutyryl-CoA: 69.4
Benzoyl-CoA: 68.0
Acetyl-CoA: 56.0
3-Methylbutyryl-CoA: 43.0
inactive: 35.2
fatty_acid: 28.9

borA5

PKS_AT (580..874): mmal

ATSignature: Methylmalonyl-CoA

Top 3 matches:: Methylmalonyl-CoA: 100.0%; Methoxymalonyl-CoA: 91.7%; Ethylmalonyl-CoA: 87.5%

minowa: Methylmalonyl-CoA

Prediction, score:

Methylmalonyl-CoA: 204.0
Ethylmalonyl-CoA: 188.6
Methoxymalonyl-CoA: 169.1
2-Methylbutyryl-CoA: 135.7
trans-1,2-CPDA: 120.1
Propionyl-CoA: 115.7
Malonyl-CoA: 101.9
CHC-CoA: 100.8
Isobutyryl-CoA: 76.6
Benzoyl-CoA: 73.1
Acetyl-CoA: 55.9
3-Methylbutyryl-CoA: 53.7
inactive: 38.8
fatty_acid: 31.5

borA6

PKS_AT (556..842): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 100.0%; inactive: 75.0%; Methylmalonyl-CoA: 54.2%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 199.3
inactive: 95.6
Methoxymalonyl-CoA: 57.2
Propionyl-CoA: 39.0
Methylmalonyl-CoA: 38.8
Isobutyryl-CoA: 19.3
fatty_acid: 14.4
Ethylmalonyl-CoA: 14.2
Acetyl-CoA: 10.8
Benzoyl-CoA: 7.3
trans-1,2-CPDA: 6.4
CHC-CoA: 0.0
3-Methylbutyryl-CoA: 0.0
2-Methylbutyryl-CoA: 0.0