BGC0000076 - 1 region(s) - antiSMASH results

Identified secondary metabolite regions using strictness 'relaxed'

BGC0000076 (Hypomyces subiculosus)

Region	Type	From	To	Most similar known cluster		Similarity
Region 1	T1PKS	1	36,275	hypothemycin	Polyketide	90%

BGC0000076 - Region 1 - T1PKS

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Location: 1 - 36,275 nt. (total: 36,275 nt) Show pHMM detection rules used

Region on contig edge.

T1PKS: cds(PKS_AT and (PKS_KS or ene_KS or mod_KS or hyb_KS or itr_KS or tra_KS))

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core biosynthetic genes

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Gene details

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MIBiG

NRPS/PKS domains

MIBiG comparison

KnownClusterBlast

NRPS/PKS modules

External annotation

Name		MIBiG
Version		3.0

Type		Subregion
Location		1 - 36,276
Label		BGC0000076

Detailed domain annotation

Selected features only

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Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000076.1	0.67	Polyketide	hypothemycin	Hypomyces subiculosus
BGC0000077.1	0.67	Polyketide	hypothemycin	Hypomyces subiculosus
BGC0001909.1	0.32	Polyketide	strobilurin	Strobilurus tenacellus
BGC0001068.1	0.29	Terpene, Polyketide	pyripyropene A	unidentified unclassified sequences.
BGC0000678.1	0.27	Terpene	pentalenolactone	Streptomyces avermitilis MA-4680 = NBRC 14893
BGC0000003.1	0.25	Polyketide	AF-toxin	Alternaria alternata
BGC0001811.1	0.23	Terpene	trichodiene-11-one	Fusarium asiaticum
BGC0000930.1	0.23	Other	deoxynivalenol	Fusarium graminearum
BGC0000056.1	0.23	Polyketide	esperamicin	Actinomadura verrucosospora
BGC0001969.1	0.22	Terpene	asperterpenoid A	Talaromyces wortmannii

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000076.1	0.87	Polyketide	hypothemycin	Hypomyces subiculosus
BGC0000077.1	0.87	Polyketide	hypothemycin	Hypomyces subiculosus
BGC0001909.1	0.65	Polyketide	strobilurin	Strobilurus tenacellus
BGC0001068.1	0.63	Terpene, Polyketide	pyripyropene A	unidentified unclassified sequences.
BGC0000678.1	0.60	Terpene	pentalenolactone	Streptomyces avermitilis MA-4680 = NBRC 14893
BGC0000003.1	0.58	Polyketide	AF-toxin	Alternaria alternata
BGC0001811.1	0.56	Terpene	trichodiene-11-one	Fusarium asiaticum
BGC0000930.1	0.56	Other	deoxynivalenol	Fusarium graminearum
BGC0000056.1	0.56	Polyketide	esperamicin	Actinomadura verrucosospora
BGC0001969.1	0.55	Terpene	asperterpenoid A	Talaromyces wortmannii

Similar known gene clusters

Module view

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NRPS/PKS products

NRPS/PKS monomers

Predicted core structure(s)

For candidate cluster 1, location 0 - 36275:

Rough prediction of core scaffold based on assumed PKS linker matching; tailoring reactions not taken into account

Polymer prediction:: (mal) + (pk)
Non-colinear ordering:: hpm3 + hpm8

Direct lookup in NORINE database: strict or relaxed

Link to NORINE database query form

NRPS/PKS monomer predictions

hpm3

PKS_AT (888..1183): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 66.7%; inactive: 58.3%; Methylmalonyl-CoA: 54.2%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 102.7
inactive: 66.9
Methoxymalonyl-CoA: 64.1
Methylmalonyl-CoA: 52.3
Isobutyryl-CoA: 37.6
Benzoyl-CoA: 25.8
Ethylmalonyl-CoA: 25.4
Propionyl-CoA: 24.5
2-Methylbutyryl-CoA: 23.1
Acetyl-CoA: 23.0
fatty_acid: 18.2
3-Methylbutyryl-CoA: 17.0
CHC-CoA: 16.5
trans-1,2-CPDA: 14.8

hpm8

PKS_AT (551..862): pk

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 87.5%; Methylmalonyl-CoA: 70.8%; 2-Methylbutyryl-CoA: 62.5%

minowa: Methylmalonyl-CoA

Prediction, score:

Methylmalonyl-CoA: 83.8
Methoxymalonyl-CoA: 76.6
Malonyl-CoA: 57.9
Ethylmalonyl-CoA: 53.2
Isobutyryl-CoA: 45.8
Propionyl-CoA: 30.0
Benzoyl-CoA: 29.3
2-Methylbutyryl-CoA: 19.9
trans-1,2-CPDA: 19.2
fatty_acid: 18.2
CHC-CoA: 15.5
3-Methylbutyryl-CoA: 11.1
inactive: 10.8
Acetyl-CoA: 0.0