BGC0000092 - 1 region(s) - antiSMASH results

Identified secondary metabolite regions using strictness 'relaxed'

BGC0000092 (Micromonospora megalomicea subsp. nigra)

Region	Type	From	To	Most similar known cluster		Similarity
Region 1	T1PKS	1	47,981	erythromycin A / erythromycin B / erythromycin C / erythromycin D	Polyketide:Modular type I + Saccharide:Hybrid/tailoring	56%

BGC0000092 - Region 1 - T1PKS

Download region GenBank file

Download region SVG

Location: 1 - 47,981 nt. (total: 47,981 nt) Show pHMM detection rules used

Region on contig edge.

T1PKS: cds(PKS_AT and (PKS_KS or ene_KS or mod_KS or hyb_KS or itr_KS or tra_KS))

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

TTA codons

reset view

zoom to selection

Gene details

Select a gene to view the details available for it

MIBiG

NRPS/PKS domains

MIBiG comparison

KnownClusterBlast

NRPS/PKS modules

External annotation

Name		MIBiG
Version		3.0

Type		Subregion
Location		1 - 47,982
Label		BGC0000092

Detailed domain annotation

Selected features only

Show module domains

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000092.1	0.89	Polyketide	megalomicin A, megalomicin B, megalomicin C1, megalomicin C2	Micromonospora megalomicea subsp. nigra
BGC0002031.1	0.34	Alkaloid	kitasetaline	Kitasatospora setae KM-6054
BGC0000041.1	0.33	Polyketide	oronofacic acid	Pseudomonas syringae
BGC0000067.1	0.29	Polyketide	geldanamycin	Streptomyces hygroscopicus subsp. duamyceticus
BGC0001141.1	0.28	Polyketide	4-epi-15-epi-brefeldin A	Penicillium brefeldianum
BGC0001892.1	0.28	Polyketide	botcinic acid	Botrytis cinerea B05.10
BGC0001164.1	0.27	Polyketide	1-heptadecene	Cyanothece sp. PCC 7822
BGC0001062.1	0.26	Polyketide	TLN-05220	Micromonospora echinospora subsp. challisensis
BGC0000651.1	0.26	Terpene	KS-505a	Streptomyces argenteolus
BGC0002019.1	0.26	Terpene	tiancilactone	Streptomyces sp. CB03234

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000092.1	0.96	Polyketide	megalomicin A, megalomicin B, megalomicin C1, megalomicin C2	Micromonospora megalomicea subsp. nigra
BGC0002031.1	0.68	Alkaloid	kitasetaline	Kitasatospora setae KM-6054
BGC0000041.1	0.66	Polyketide	oronofacic acid	Pseudomonas syringae
BGC0000067.1	0.62	Polyketide	geldanamycin	Streptomyces hygroscopicus subsp. duamyceticus
BGC0001141.1	0.62	Polyketide	4-epi-15-epi-brefeldin A	Penicillium brefeldianum
BGC0001892.1	0.62	Polyketide	botcinic acid	Botrytis cinerea B05.10
BGC0001164.1	0.61	Polyketide	1-heptadecene	Cyanothece sp. PCC 7822
BGC0001062.1	0.60	Polyketide	TLN-05220	Micromonospora echinospora subsp. challisensis
BGC0000651.1	0.60	Terpene	KS-505a	Streptomyces argenteolus
BGC0002019.1	0.60	Terpene	tiancilactone	Streptomyces sp. CB03234

Similar known gene clusters

Module view

Legend

NRPS/PKS products

NRPS/PKS monomers

Predicted core structure(s)

For candidate cluster 1, location 0 - 47981:

Rough prediction of core scaffold based on assumed PKS linker matching; tailoring reactions not taken into account

Polymer prediction:: (pk - Me-ohmal - Me-ohmal) + (Me-ohmal - Me-redmal) + (Me-ohmal - Me-ohmal)
Non-colinear ordering:: megAI + megAII + megAIII

Direct lookup in NORINE database: strict or relaxed

Link to NORINE database query form

NRPS/PKS monomer predictions

megAI

PKS_AT (110..404): pk

ATSignature: Propionyl-CoA

Top 3 matches:: Propionyl-CoA: 100.0%; 2-Methylbutyryl-CoA: 75.0%; Ethylmalonyl-CoA: 66.7%

minowa: Propionyl-CoA

Prediction, score:

Propionyl-CoA: 218.3
2-Methylbutyryl-CoA: 166.0
Methylmalonyl-CoA: 126.5
Ethylmalonyl-CoA: 117.4
Methoxymalonyl-CoA: 108.1
CHC-CoA: 85.5
trans-1,2-CPDA: 77.0
Malonyl-CoA: 70.4
Isobutyryl-CoA: 42.1
Acetyl-CoA: 41.5
fatty_acid: 29.0
Benzoyl-CoA: 25.9
3-Methylbutyryl-CoA: 20.1
inactive: 18.0

PKS_AT (1084..1384): mmal

ATSignature: Methylmalonyl-CoA

Top 3 matches:: Methylmalonyl-CoA: 100.0%; Methoxymalonyl-CoA: 95.8%; Ethylmalonyl-CoA: 91.7%

minowa: Methylmalonyl-CoA

Prediction, score:

Methylmalonyl-CoA: 215.0
Ethylmalonyl-CoA: 202.7
Methoxymalonyl-CoA: 180.2
2-Methylbutyryl-CoA: 143.8
trans-1,2-CPDA: 122.6
Propionyl-CoA: 121.7
Malonyl-CoA: 109.6
CHC-CoA: 94.3
Isobutyryl-CoA: 86.5
Benzoyl-CoA: 60.2
Acetyl-CoA: 45.6
fatty_acid: 44.8
3-Methylbutyryl-CoA: 42.1
inactive: 29.3

PKS_AT (2567..2864): mmal

ATSignature: Methylmalonyl-CoA

Top 3 matches:: Methylmalonyl-CoA: 100.0%; Methoxymalonyl-CoA: 95.8%; Ethylmalonyl-CoA: 91.7%

minowa: Methylmalonyl-CoA

Prediction, score:

Methylmalonyl-CoA: 219.5
Ethylmalonyl-CoA: 212.6
Methoxymalonyl-CoA: 177.0
2-Methylbutyryl-CoA: 142.3
trans-1,2-CPDA: 130.3
Propionyl-CoA: 117.0
Malonyl-CoA: 109.9
CHC-CoA: 98.1
Isobutyryl-CoA: 73.8
Benzoyl-CoA: 70.7
Acetyl-CoA: 60.7
inactive: 39.8
3-Methylbutyryl-CoA: 31.8
fatty_acid: 31.7

megAII

PKS_AT (561..859): mmal

ATSignature: Methylmalonyl-CoA

Top 3 matches:: Methylmalonyl-CoA: 100.0%; Methoxymalonyl-CoA: 95.8%; Ethylmalonyl-CoA: 91.7%

minowa: Methylmalonyl-CoA

Prediction, score:

Methylmalonyl-CoA: 214.7
Ethylmalonyl-CoA: 205.7
Methoxymalonyl-CoA: 179.9
2-Methylbutyryl-CoA: 130.0
trans-1,2-CPDA: 117.5
Malonyl-CoA: 110.5
Propionyl-CoA: 102.7
CHC-CoA: 86.2
Isobutyryl-CoA: 78.9
Benzoyl-CoA: 59.8
Acetyl-CoA: 45.1
3-Methylbutyryl-CoA: 39.8
fatty_acid: 32.0
inactive: 31.8

PKS_AT (2012..2309): mmal

ATSignature: Methylmalonyl-CoA

Top 3 matches:: Methylmalonyl-CoA: 100.0%; Methoxymalonyl-CoA: 91.7%; Ethylmalonyl-CoA: 83.3%

minowa: Methylmalonyl-CoA

Prediction, score:

Methylmalonyl-CoA: 210.4
Ethylmalonyl-CoA: 192.2
Methoxymalonyl-CoA: 170.6
2-Methylbutyryl-CoA: 135.7
trans-1,2-CPDA: 117.0
Propionyl-CoA: 110.3
Malonyl-CoA: 98.9
CHC-CoA: 88.1
Isobutyryl-CoA: 72.9
Benzoyl-CoA: 64.8
Acetyl-CoA: 54.7
fatty_acid: 37.3
inactive: 34.9
3-Methylbutyryl-CoA: 13.6

megAIII

PKS_AT (575..871): mmal

ATSignature: Methylmalonyl-CoA

Top 3 matches:: Methylmalonyl-CoA: 100.0%; Methoxymalonyl-CoA: 91.7%; Ethylmalonyl-CoA: 87.5%

minowa: Methylmalonyl-CoA

Prediction, score:

Methylmalonyl-CoA: 212.2
Ethylmalonyl-CoA: 197.2
Methoxymalonyl-CoA: 162.9
2-Methylbutyryl-CoA: 128.5
trans-1,2-CPDA: 113.8
Propionyl-CoA: 107.6
Malonyl-CoA: 102.0
CHC-CoA: 91.2
Isobutyryl-CoA: 82.4
Benzoyl-CoA: 69.4
Acetyl-CoA: 47.4
3-Methylbutyryl-CoA: 47.4
fatty_acid: 36.5
inactive: 33.7

PKS_AT (2045..2336): mmal

ATSignature: Methylmalonyl-CoA

Top 3 matches:: Methylmalonyl-CoA: 100.0%; Methoxymalonyl-CoA: 95.8%; Ethylmalonyl-CoA: 91.7%

minowa: Methylmalonyl-CoA

Prediction, score:

Methylmalonyl-CoA: 218.8
Ethylmalonyl-CoA: 208.2
Methoxymalonyl-CoA: 177.7
2-Methylbutyryl-CoA: 142.6
trans-1,2-CPDA: 122.2
Malonyl-CoA: 119.5
Propionyl-CoA: 103.4
CHC-CoA: 102.5
Isobutyryl-CoA: 75.5
Benzoyl-CoA: 73.6
Acetyl-CoA: 58.8
inactive: 46.0
3-Methylbutyryl-CoA: 35.8
fatty_acid: 35.5