BGC0000168 - 1 region(s) - antiSMASH results

Identified secondary metabolite regions using strictness 'relaxed'

BGC0000168 (Penicillium aethiopicum)

Region	Type	From	To	Most similar known cluster		Similarity
Region 1	T1PKS,indole	1	51,400	neosartoricin B	Polyketide	80%

BGC0000168 - Region 1 - T1PKS,indole

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Location: 1 - 51,400 nt. (total: 51,400 nt) Show pHMM detection rules used

Region on contig edge.

T1PKS: cds(PKS_AT and (PKS_KS or ene_KS or mod_KS or hyb_KS or itr_KS or tra_KS))
indole: (indsynth or dmat or indole_PTase)

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Gene details

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MIBiG

NRPS/PKS domains

MIBiG comparison

KnownClusterBlast

NRPS/PKS modules

External annotation

Name		MIBiG
Version		3.0

Type		Subregion
Location		1 - 51,401
Label		BGC0000168

Detailed domain annotation

Selected features only

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Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000168.1	1.16	Polyketide	viridicatumtoxin, previridicatumtoxin, 5-hydroxyanthrotainin, 8-O-desmethylanthrotainin	Penicillium aethiopicum
BGC0000013.1	0.55	Polyketide	alternariol	Aspergillus nidulans FGSC A4
BGC0001284.1	0.45	Terpene	alternariol	Parastagonospora nodorum SN15
BGC0001304.1	0.45	Polyketide	aflavarin	Aspergillus flavus NRRL3357
BGC0000056.1	0.45	Polyketide	esperamicin	Actinomadura verrucosospora
BGC0001258.1	0.45	Polyketide	1,3,6,8-tetrahydroxynaphthalene	Glarea lozoyensis
BGC0001257.1	0.45	Polyketide	1,3,6,8-tetrahydroxynaphthalene	Nodulisporium sp. ATCC74245
BGC0001265.1	0.45	Polyketide	melanin	Bipolaris oryzae
BGC0001906.1	0.45	Polyketide	naphthalene	Daldinia eschscholzii IFB-TL01
BGC0000046.1	0.44	Polyketide	depudecin	Alternaria brassicicola

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000168.1	0.87	Polyketide	viridicatumtoxin, previridicatumtoxin, 5-hydroxyanthrotainin, 8-O-desmethylanthrotainin	Penicillium aethiopicum
BGC0000013.1	0.62	Polyketide	alternariol	Aspergillus nidulans FGSC A4
BGC0001858.1	0.62	Polyketide	alternapyrone B, alternapyrone C, alternapyrone D, alternapyrone E, alternapyrone F	Parastagonospora nodorum SN15
BGC0001277.1	0.61	Terpene	nivalenol, vomitoxin, 3-acetyldeoxynivalenol, 15-acetyldeoxynivalenol, neosolaniol, calonectrin, apotrichodiol, isotrichotriol, 15-deacetylcalonectrin, T-2 toxin, 3-acetyl T-2 toxin, trichodiene	Fusarium graminearum
BGC0001811.1	0.61	Terpene	trichodiene-11-one	Fusarium asiaticum
BGC0000930.1	0.61	Other	deoxynivalenol	Fusarium graminearum
BGC0001280.1	0.60	Polyketide	betaenone C, betaenone A	Phoma betae
BGC0001264.1	0.60	Polyketide	betaenone A, betaenone B, betaenone C	Phoma betae
BGC0000046.1	0.59	Polyketide	depudecin	Alternaria brassicicola
BGC0000631.1	0.58	Terpene	botrydial	Botrytis cinerea B05.10

Similar known gene clusters

Module view

Legend

NRPS/PKS products

NRPS/PKS monomers

Predicted core structure(s)

For candidate cluster 1, location 531 - 46109:

Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:: (mal)

Direct lookup in NORINE database: strict or relaxed

Link to NORINE database query form

NRPS/PKS monomer predictions

ADI24926.1

PKS_AT (937..1235): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 75.0%; Methylmalonyl-CoA: 62.5%; Propionyl-CoA: 54.2%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 87.6
Methoxymalonyl-CoA: 63.4
Methylmalonyl-CoA: 62.5
inactive: 44.1
Isobutyryl-CoA: 29.4
Propionyl-CoA: 28.2
Benzoyl-CoA: 26.5
2-Methylbutyryl-CoA: 24.6
3-Methylbutyryl-CoA: 22.1
Ethylmalonyl-CoA: 18.3
fatty_acid: 15.9
Acetyl-CoA: 14.9
CHC-CoA: 14.8
trans-1,2-CPDA: 13.5

ADI24927.1

Search NORINE for peptide: strict or relaxed

AMP-binding (153..592): phe

NRPSPredictor2: phe

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aromatic
Large clusters prediction:: N/A
Small clusters prediction:: phe, trp
Single AA prediction:: phe

Stachelhaus prediction details:

Stachelhaus sequence:: mmwgytalgk
Nearest Stachelhaus code:: N, A
Stachelhaus code match:: 0% (weak)