BGC0000233 - 1 region(s) - antiSMASH results

Identified secondary metabolite regions using strictness 'relaxed'

BGC0000233 (Streptomyces griseoruber)

Region	Type	From	To	Most similar known cluster		Similarity
Region 1	PKS-like,T1PKS,T2PKS	1	45,603	cinerubin B	Polyketide:Type II	42%

BGC0000233 - Region 1 - PKS-like,T1PKS,T2PKS

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Location: 1 - 45,603 nt. (total: 45,603 nt) Show pHMM detection rules used

Region on contig edge.

PKS-like: (t2pks2 or ksIII)
T1PKS: cds(PKS_AT and (PKS_KS or ene_KS or mod_KS or hyb_KS or itr_KS or tra_KS))
T2PKS: (t2ks and t2clf)

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core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

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TTA codons

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Gene details

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MIBiG

NRPS/PKS domains

MIBiG comparison

KnownClusterBlast

NRPS/PKS modules

External annotation

Name		MIBiG
Version		3.0

Type		Subregion
Location		1 - 45,604
Label		BGC0000233

Detailed domain annotation

Selected features only

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Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000233.1	1.37	Polyketide	hedamycin	Streptomyces griseoruber
BGC0001858.1	0.87	Polyketide	alternapyrone B, alternapyrone C, alternapyrone D, alternapyrone E, alternapyrone F	Parastagonospora nodorum SN15
BGC0000041.1	0.82	Polyketide	oronofacic acid	Pseudomonas syringae
BGC0000046.1	0.79	Polyketide	depudecin	Alternaria brassicicola
BGC0001280.1	0.79	Polyketide	betaenone C, betaenone A	Phoma betae
BGC0001264.1	0.79	Polyketide	betaenone A, betaenone B, betaenone C	Phoma betae
BGC0001068.1	0.73	Terpene, Polyketide	pyripyropene A	unidentified unclassified sequences.
BGC0000056.1	0.72	Polyketide	esperamicin	Actinomadura verrucosospora
BGC0000003.1	0.69	Polyketide	AF-toxin	Alternaria alternata
BGC0001141.1	0.66	Polyketide	4-epi-15-epi-brefeldin A	Penicillium brefeldianum

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000233.1	0.87	Polyketide	hedamycin	Streptomyces griseoruber
BGC0000248.1	0.67	Polyketide	naphtocyclinone	Streptomyces arenae
BGC0000041.1	0.66	Polyketide	oronofacic acid	Pseudomonas syringae
BGC0000228.1	0.65	Polyketide	granaticin	Streptomyces violaceoruber
BGC0001858.1	0.62	Polyketide	alternapyrone B, alternapyrone C, alternapyrone D, alternapyrone E, alternapyrone F	Parastagonospora nodorum SN15
BGC0000272.1	0.61	Polyketide	spore pigment	Streptomyces collinus
BGC0000046.1	0.60	Polyketide	depudecin	Alternaria brassicicola
BGC0001280.1	0.60	Polyketide	betaenone C, betaenone A	Phoma betae
BGC0001264.1	0.60	Polyketide	betaenone A, betaenone B, betaenone C	Phoma betae
BGC0000231.1	0.59	Polyketide	griseusin	Streptomyces griseus

Similar known gene clusters

Module view

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NRPS/PKS products

NRPS/PKS monomers

Type II PKS

Predicted core structure(s)

For candidate cluster 1, location 0 - 45603:

Rough prediction of core scaffold based on assumed PKS linker matching; tailoring reactions not taken into account

Polymer prediction:: (mal) + (ccmal)
Non-colinear ordering:: AAP85336.1 + AAP85335.1

Direct lookup in NORINE database: strict or relaxed

For candidate cluster 2, location 0 - 30434:

Rough prediction of core scaffold based on assumed PKS linker matching; tailoring reactions not taken into account

Polymer prediction:: (mal) + (ccmal)
Non-colinear ordering:: AAP85336.1 + AAP85335.1

Direct lookup in NORINE database: strict or relaxed

For candidate cluster 3, location 0 - 29332:

Rough prediction of core scaffold based on assumed PKS linker matching; tailoring reactions not taken into account

Polymer prediction:: (mal) + (ccmal)
Non-colinear ordering:: AAP85336.1 + AAP85335.1

Direct lookup in NORINE database: strict or relaxed

For candidate cluster 4, location 2468 - 45603:

Rough prediction of core scaffold based on assumed PKS linker matching; tailoring reactions not taken into account

Polymer prediction:: (mal) + (ccmal)
Non-colinear ordering:: AAP85336.1 + AAP85335.1

Direct lookup in NORINE database: strict or relaxed

Link to NORINE database query form

NRPS/PKS monomer predictions

AAP85335.1

PKS_AT (573..862): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 100.0%; inactive: 79.2%; Propionyl-CoA: 54.2%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 198.3
inactive: 103.3
Methoxymalonyl-CoA: 61.5
Methylmalonyl-CoA: 57.8
Propionyl-CoA: 34.6
Isobutyryl-CoA: 32.2
Acetyl-CoA: 19.0
fatty_acid: 11.3
Ethylmalonyl-CoA: 11.3
Benzoyl-CoA: 8.0
CHC-CoA: 7.9
3-Methylbutyryl-CoA: 6.3
2-Methylbutyryl-CoA: 0.3
trans-1,2-CPDA: 0.0

AAP85336.1

PKS_AT (541..835): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 100.0%; inactive: 70.8%; Methylmalonyl-CoA: 62.5%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 179.8
inactive: 76.9
Methoxymalonyl-CoA: 64.4
Methylmalonyl-CoA: 53.2
Isobutyryl-CoA: 27.6
Propionyl-CoA: 25.6
Ethylmalonyl-CoA: 25.0
Acetyl-CoA: 18.2
Benzoyl-CoA: 16.2
3-Methylbutyryl-CoA: 12.6
CHC-CoA: 8.0
fatty_acid: 5.0
2-Methylbutyryl-CoA: 1.6
trans-1,2-CPDA: 0.0

AAP85359.1

PKS_AT (4..286): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 66.7%; Methylmalonyl-CoA: 58.3%; inactive: 54.2%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 50.9
Methoxymalonyl-CoA: 37.6
Methylmalonyl-CoA: 34.6
Isobutyryl-CoA: 19.9
Propionyl-CoA: 17.9
inactive: 15.5
fatty_acid: 14.9
2-Methylbutyryl-CoA: 8.2
Ethylmalonyl-CoA: 4.0
CHC-CoA: 3.2
trans-1,2-CPDA: 0.0
Benzoyl-CoA: 0.0
Acetyl-CoA: 0.0
3-Methylbutyryl-CoA: 0.0

Type II PKS gene cluster prediction details

Cluster section:: 2468 to 45603
Starter unit(s):: hexadienyl-CoA (Score: 1331.0; E-value: 0)
propionyl-CoA (Score: 150.0; E-value: 9.82e-43)
Product class(es):: benzoisochromanequinone

AAP85336.1: AT (Score: 187.8; E-value: 6.1e-58); AT BAB72049.1_Aklavinone_propionyl-CoA (Score: 150.0; E-value: 9.82e-43)
AAP85337.1: KSIII (Score: 533.1; E-value: 6.3e-163); KSIII AAP85337.1_Hedamycin_hexadienyl-CoA (Score: 695.0; E-value: 0.0)
AAP85348.1: GT (Score: 394.2; E-value: 1.9e-120)
AAP85354.1: GT (Score: 387.5; E-value: 2.1e-118)
AAP85357.1: OXY (Score: 49.3; E-value: 9.1e-16)
AAP85359.1: AT (Score: 424.1; E-value: 8.8e-130); AT AAP85359.1_Hedamycin_hexadienyl-CoA (Score: 636.0; E-value: 0.0)
AAP85360.1: CYC C7-C12 (Score: 318.4; E-value: 8.8e-98); ACP (Score: 94.6; E-value: 6.3e-30)
AAP85361.1: CLF (Score: 545.3; E-value: 1.9e-166)
AAP85362.1: KS (Score: 727.3; E-value: 1.1e-221)
AAP85363.1: CYC C5-C14 (Score: 319.4; E-value: 4.5e-98)
AAP85364.1: KR C9 (Score: 446.5; E-value: 6.5e-137)