BGC0001296 - 1 region(s) - antiSMASH results

Identified secondary metabolite regions using strictness 'relaxed'

BGC0001296 (Streptomyces sp. MSC090213JE08)

Region	Type	From	To	Most similar known cluster		Similarity
Region 1	T1PKS	1	43,735	argimycin PI / argimycin PII / nigrifactin / argimycin PIV / argimycin PV / argimycin PVI / argimycin PIX	Polyketide:Modular type I	32%

BGC0001296 - Region 1 - T1PKS

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Location: 1 - 43,735 nt. (total: 43,735 nt) Show pHMM detection rules used

Region on contig edge.

T1PKS: cds(PKS_AT and (PKS_KS or ene_KS or mod_KS or hyb_KS or itr_KS or tra_KS))

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core biosynthetic genes

additional biosynthetic genes

transport-related genes

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TTA codons

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Gene details

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MIBiG

NRPS/PKS domains

MIBiG comparison

KnownClusterBlast

NRPS/PKS modules

External annotation

Name		MIBiG
Version		3.0

Type		Subregion
Location		1 - 43,736
Label		BGC0001296

Detailed domain annotation

Selected features only

Show module domains

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001296.1	0.94	Polyketide	streptazone E	Streptomyces sp. MSC090213JE08
BGC0001433.1	0.44	Polyketide	argimycin PI, argimycin PII, nigrifactin, argimycin PIV, argimycin PV, argimycin PVI, argimycin PIX	Streptomyces argillaceus
BGC0000041.1	0.35	Polyketide	oronofacic acid	Pseudomonas syringae
BGC0000067.1	0.31	Polyketide	geldanamycin	Streptomyces hygroscopicus subsp. duamyceticus
BGC0000068.1	0.30	Polyketide	geldanamycin	Streptomyces hygroscopicus
BGC0001273.1	0.29	Polyketide	asperlactone	Aspergillus ochraceus
BGC0001276.1	0.29	Polyketide	6-methylsalicyclic acid	Aspergillus terreus
BGC0001275.1	0.28	Polyketide	6-methylsalicyclic acid	Glarea lozoyensis
BGC0001244.1	0.28	Polyketide	(-)-Mellein	Parastagonospora nodorum
BGC0000353.1	0.26	NRP	tacrolimus	Streptomyces sp. MA6548

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001296.1	0.98	Polyketide	streptazone E	Streptomyces sp. MSC090213JE08
BGC0001433.1	0.75	Polyketide	argimycin PI, argimycin PII, nigrifactin, argimycin PIV, argimycin PV, argimycin PVI, argimycin PIX	Streptomyces argillaceus
BGC0000041.1	0.68	Polyketide	oronofacic acid	Pseudomonas syringae
BGC0000067.1	0.64	Polyketide	geldanamycin	Streptomyces hygroscopicus subsp. duamyceticus
BGC0000068.1	0.63	Polyketide	geldanamycin	Streptomyces hygroscopicus
BGC0001273.1	0.63	Polyketide	asperlactone	Aspergillus ochraceus
BGC0001276.1	0.62	Polyketide	6-methylsalicyclic acid	Aspergillus terreus
BGC0001275.1	0.62	Polyketide	6-methylsalicyclic acid	Glarea lozoyensis
BGC0001244.1	0.62	Polyketide	(-)-Mellein	Parastagonospora nodorum
BGC0000353.1	0.60	NRP	tacrolimus	Streptomyces sp. MA6548

Similar known gene clusters

Module view

Legend

NRPS/PKS products

NRPS/PKS monomers

Predicted core structure(s)

For candidate cluster 1, location 0 - 43735:

Rough prediction of core scaffold based on assumed PKS linker matching; tailoring reactions not taken into account

Polymer prediction:: (mal - ccmal - ccmal) + (ccmal - ccmal) + (ccmal)
Non-colinear ordering:: stzD + stzC + stzB

Direct lookup in NORINE database: strict or relaxed

Link to NORINE database query form

NRPS/PKS monomer predictions

stzD

PKS_AT (560..853): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 91.7%; inactive: 75.0%; Propionyl-CoA: 54.2%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 204.0
inactive: 96.2
Methoxymalonyl-CoA: 76.3
Methylmalonyl-CoA: 67.8
Ethylmalonyl-CoA: 36.6
Isobutyryl-CoA: 35.1
Propionyl-CoA: 34.2
2-Methylbutyryl-CoA: 28.1
Acetyl-CoA: 27.6
Benzoyl-CoA: 16.3
fatty_acid: 13.5
trans-1,2-CPDA: 12.5
CHC-CoA: 9.9
3-Methylbutyryl-CoA: 5.6

PKS_AT (1575..1868): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 95.8%; inactive: 75.0%; Propionyl-CoA: 58.3%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 186.6
inactive: 85.6
Methoxymalonyl-CoA: 75.2
Methylmalonyl-CoA: 66.0
Propionyl-CoA: 35.0
Isobutyryl-CoA: 26.7
fatty_acid: 21.2
Acetyl-CoA: 20.5
Ethylmalonyl-CoA: 17.1
2-Methylbutyryl-CoA: 15.7
CHC-CoA: 11.5
Benzoyl-CoA: 11.2
trans-1,2-CPDA: 8.2
3-Methylbutyryl-CoA: 0.0

PKS_AT (3309..3608): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 95.8%; inactive: 87.5%; 2-Rhyd-Malonyl-CoA: 54.2%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 207.7
inactive: 100.1
Methoxymalonyl-CoA: 69.0
Methylmalonyl-CoA: 59.2
Propionyl-CoA: 31.4
Isobutyryl-CoA: 29.4
Ethylmalonyl-CoA: 26.1
2-Methylbutyryl-CoA: 21.3
Benzoyl-CoA: 16.5
Acetyl-CoA: 12.4
CHC-CoA: 9.6
fatty_acid: 8.1
trans-1,2-CPDA: 0.0
3-Methylbutyryl-CoA: 0.0

stzC

PKS_AT (616..908): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 95.8%; inactive: 75.0%; Propionyl-CoA: 58.3%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 186.4
inactive: 85.6
Methoxymalonyl-CoA: 75.8
Methylmalonyl-CoA: 67.2
Propionyl-CoA: 35.8
Isobutyryl-CoA: 27.5
fatty_acid: 21.6
Acetyl-CoA: 20.7
Ethylmalonyl-CoA: 18.2
2-Methylbutyryl-CoA: 16.3
CHC-CoA: 11.5
Benzoyl-CoA: 11.2
trans-1,2-CPDA: 8.2
3-Methylbutyryl-CoA: 0.0

PKS_AT (2329..2625): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 95.8%; inactive: 79.2%; Propionyl-CoA: 54.2%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 187.8
inactive: 88.6
Methoxymalonyl-CoA: 69.6
Methylmalonyl-CoA: 66.6
Propionyl-CoA: 40.7
Isobutyryl-CoA: 37.2
Acetyl-CoA: 26.1
Ethylmalonyl-CoA: 24.5
fatty_acid: 19.2
2-Methylbutyryl-CoA: 16.2
CHC-CoA: 12.2
Benzoyl-CoA: 11.4
trans-1,2-CPDA: 9.6
3-Methylbutyryl-CoA: 0.0

stzB

PKS_AT (628..917): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 95.8%; inactive: 75.0%; Propionyl-CoA: 58.3%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 176.8
inactive: 75.4
Methoxymalonyl-CoA: 61.5
Methylmalonyl-CoA: 60.4
Isobutyryl-CoA: 39.8
Propionyl-CoA: 35.8
Acetyl-CoA: 30.5
Ethylmalonyl-CoA: 18.1
fatty_acid: 15.3
Benzoyl-CoA: 11.4
2-Methylbutyryl-CoA: 10.5
trans-1,2-CPDA: 10.1
CHC-CoA: 7.8
3-Methylbutyryl-CoA: 0.0