BGC0001405 - 1 region(s) - antiSMASH results

Identified secondary metabolite regions using strictness 'relaxed'

BGC0001405 (Chaetomium globosum CBS 148.51)

Region	Type	From	To	Most similar known cluster		Similarity
Region 1	T1PKS	1	59,510	asperfuranone	Polyketide	45%

BGC0001405 - Region 1 - T1PKS

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Location: 1 - 59,510 nt. (total: 59,510 nt) Show pHMM detection rules used

Region on contig edge.

T1PKS: cds(PKS_AT and (PKS_KS or ene_KS or mod_KS or hyb_KS or itr_KS or tra_KS))

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core biosynthetic genes

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Gene details

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MIBiG

NRPS/PKS domains

MIBiG comparison

KnownClusterBlast

NRPS/PKS modules

External annotation

Name		MIBiG
Version		3.0

Type		Subregion
Location		1 - 59,511
Label		BGC0001405

Detailed domain annotation

Selected features only

Show module domains

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001405.1	1.19	Polyketide	chaetoviridin E, 11-epichaetomugilin A	Chaetomium globosum CBS 148.51
BGC0000013.1	0.49	Polyketide	alternariol	Aspergillus nidulans FGSC A4
BGC0001068.1	0.48	Terpene, Polyketide	pyripyropene A	unidentified unclassified sequences.
BGC0000056.1	0.46	Polyketide	esperamicin	Actinomadura verrucosospora
BGC0001280.1	0.43	Polyketide	betaenone C, betaenone A	Phoma betae
BGC0001264.1	0.43	Polyketide	betaenone A, betaenone B, betaenone C	Phoma betae
BGC0000048.1	0.42	Polyketide	dothistromin	Dothistroma septosporum
BGC0000046.1	0.40	Polyketide	depudecin	Alternaria brassicicola
BGC0000099.1	0.40	Polyketide	monascorubrin	Talaromyces marneffei
BGC0000057.1	0.39	Polyketide	F9775A, F9775B, orsellinic acid	Aspergillus nidulans FGSC A4

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001405.1	1.00	Polyketide	chaetoviridin E, 11-epichaetomugilin A	Chaetomium globosum CBS 148.51
BGC0000099.1	0.72	Polyketide	monascorubrin	Talaromyces marneffei
BGC0000161.1	0.66	Polyketide	isoterrein	Aspergillus terreus NIH2624
BGC0001542.1	0.66	Polyketide	cercosporin	Cercospora zeina
BGC0000013.1	0.65	Polyketide	alternariol	Aspergillus nidulans FGSC A4
BGC0000048.1	0.63	Polyketide	dothistromin	Dothistroma septosporum
BGC0001144.1	0.63	Polyketide	neosartoricin B	Trichophyton tonsurans CBS 112818
BGC0001858.1	0.62	Polyketide	alternapyrone B, alternapyrone C, alternapyrone D, alternapyrone E, alternapyrone F	Parastagonospora nodorum SN15
BGC0001280.1	0.61	Polyketide	betaenone C, betaenone A	Phoma betae
BGC0001264.1	0.61	Polyketide	betaenone A, betaenone B, betaenone C	Phoma betae

Similar known gene clusters

Module view

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NRPS/PKS products

NRPS/PKS monomers

Predicted core structure(s)

For candidate cluster 1, location 3 - 59510:

Rough prediction of core scaffold based on assumed PKS linker matching; tailoring reactions not taken into account

Polymer prediction:: (Me-pk) + (mal)
Non-colinear ordering:: CHGG_07638 + CHGG_07645 + CHGG_07646

Direct lookup in NORINE database: strict or relaxed

For candidate cluster 2, location 3 - 39801:

Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:: (Me-pk)

Direct lookup in NORINE database: strict or relaxed

For candidate cluster 3, location 23582 - 59510:

Rough prediction of core scaffold based on assumed PKS linker matching; tailoring reactions not taken into account

Polymer prediction:: (mal)
Non-colinear ordering:: CHGG_07645 + CHGG_07646

Direct lookup in NORINE database: strict or relaxed

Link to NORINE database query form

NRPS/PKS monomer predictions

CHGG_07638

PKS_AT (557..921): pk

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 62.5%

minowa: Methylmalonyl-CoA

Prediction, score:

Methylmalonyl-CoA: 63.9
Methoxymalonyl-CoA: 56.9
Malonyl-CoA: 51.8
Isobutyryl-CoA: 32.4
Ethylmalonyl-CoA: 32.2
Benzoyl-CoA: 20.5
trans-1,2-CPDA: 19.5
Propionyl-CoA: 15.5
fatty_acid: 9.3
CHC-CoA: 8.8
2-Methylbutyryl-CoA: 7.7
inactive: 0.0
Acetyl-CoA: 0.0
3-Methylbutyryl-CoA: 0.0

CHGG_07645

PKS_AT (947..1175): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 58.3%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 75.8
Methoxymalonyl-CoA: 65.4
Methylmalonyl-CoA: 55.7
inactive: 55.3
Ethylmalonyl-CoA: 46.4
CHC-CoA: 26.0
Benzoyl-CoA: 25.6
Propionyl-CoA: 24.5
2-Methylbutyryl-CoA: 24.2
Isobutyryl-CoA: 23.7
trans-1,2-CPDA: 19.4
Acetyl-CoA: 18.7
fatty_acid: 18.0
3-Methylbutyryl-CoA: 10.0