BGC0001457 - 1 region(s) - antiSMASH results

Identified secondary metabolite regions using strictness 'relaxed'

BGC0001457 (Streptomyces caniferus)

Region	Type	From	To	Most similar known cluster		Similarity
Region 1	T1PKS,NRPS	1	54,671	stigmatellin	NRP + Polyketide:Modular type I	15%

BGC0001457 - Region 1 - NRPS,T1PKS

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Location: 1 - 54,671 nt. (total: 54,671 nt) Show pHMM detection rules used

Region on contig edge.

T1PKS: cds(PKS_AT and (PKS_KS or ene_KS or mod_KS or hyb_KS or itr_KS or tra_KS))
NRPS: cds(Condensation and (AMP-binding or A-OX))

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core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

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TTA codons

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Gene details

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MIBiG

NRPS/PKS domains

MIBiG comparison

KnownClusterBlast

NRPS/PKS modules

External annotation

Name		MIBiG
Version		3.0

Type		Subregion
Location		1 - 54,672
Label		BGC0001457

Detailed domain annotation

Selected features only

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Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001457.1	1.84	NRP	jomthonic acid A, jomthonic acid B, jomthonic acid C	Streptomyces caniferus
BGC0001050.1	0.65	NRP, Polyketide	thalassospiramide A	Tistrella bauzanensis
BGC0000041.1	0.61	Polyketide	oronofacic acid	Pseudomonas syringae
BGC0001162.1	0.58	Polyketide	1-heptadecene	Moorea producens JHB
BGC0001163.1	0.58	Polyketide	1-heptadecene	Moorea producens 3L
BGC0000313.1	0.52	NRP	beauvericin	Beauveria bassiana
BGC0000342.1	0.51	NRP	enniatin	Fusarium equiseti
BGC0001873.1	0.50	NRP	pyrrolizixenamide A	Xenorhabdus szentirmaii DSM 16338
BGC0001132.1	0.50	NRP	xenotetrapeptide	Xenorhabdus nematophila ATCC 19061
BGC0001068.1	0.50	Terpene, Polyketide	pyripyropene A	unidentified unclassified sequences.

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001457.1	0.98	NRP	jomthonic acid A, jomthonic acid B, jomthonic acid C	Streptomyces caniferus
BGC0001050.1	0.66	NRP, Polyketide	thalassospiramide A	Tistrella bauzanensis
BGC0000041.1	0.64	Polyketide	oronofacic acid	Pseudomonas syringae
BGC0001162.1	0.62	Polyketide	1-heptadecene	Moorea producens JHB
BGC0001163.1	0.62	Polyketide	1-heptadecene	Moorea producens 3L
BGC0000313.1	0.59	NRP	beauvericin	Beauveria bassiana
BGC0000342.1	0.59	NRP	enniatin	Fusarium equiseti
BGC0001873.1	0.58	NRP	pyrrolizixenamide A	Xenorhabdus szentirmaii DSM 16338
BGC0001132.1	0.58	NRP	xenotetrapeptide	Xenorhabdus nematophila ATCC 19061
BGC0001068.1	0.58	Terpene, Polyketide	pyripyropene A	unidentified unclassified sequences.

Similar known gene clusters

Module view

Legend

NRPS/PKS products

NRPS/PKS monomers

Predicted core structure(s)

For candidate cluster 1, location 0 - 54671:

Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:: (ccmal) + (X)

Direct lookup in NORINE database: strict or relaxed

Link to NORINE database query form

NRPS/PKS monomer predictions

ctg1_orf15

PKS_AT (618..903): mmal

ATSignature: Malonyl-CoA, Methylmalonyl-CoA

Top 3 matches:: Malonyl-CoA: 70.8%; Methylmalonyl-CoA: 70.8%; Isobutyryl-CoA: 66.7%

minowa: Methylmalonyl-CoA

Prediction, score:

Methylmalonyl-CoA: 144.1
Methoxymalonyl-CoA: 116.8
Malonyl-CoA: 110.1
Isobutyryl-CoA: 109.2
Ethylmalonyl-CoA: 108.7
Benzoyl-CoA: 95.7
Acetyl-CoA: 70.9
Propionyl-CoA: 68.5
2-Methylbutyryl-CoA: 68.4
CHC-CoA: 60.3
trans-1,2-CPDA: 57.6
fatty_acid: 49.7
3-Methylbutyryl-CoA: 42.8
inactive: 36.4

PKS_AT (1057..1352): pk

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 62.5%; Methylmalonyl-CoA: 58.3%; CE-Malonyl-CoA: 54.2%

minowa: Methylmalonyl-CoA

Prediction, score:

Methylmalonyl-CoA: 111.4
Malonyl-CoA: 103.1
Methoxymalonyl-CoA: 94.4
Isobutyryl-CoA: 87.2
Ethylmalonyl-CoA: 71.7
Propionyl-CoA: 54.1
CHC-CoA: 52.5
2-Methylbutyryl-CoA: 45.7
trans-1,2-CPDA: 40.3
inactive: 38.9
Acetyl-CoA: 36.7
Benzoyl-CoA: 32.0
fatty_acid: 28.7
3-Methylbutyryl-CoA: 21.7

ctg1_orf16

PKS_AT (562..859): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 83.3%; inactive: 75.0%; Methylmalonyl-CoA: 62.5%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 171.2
inactive: 118.7
Methoxymalonyl-CoA: 95.1
Methylmalonyl-CoA: 91.5
Propionyl-CoA: 71.2
CHC-CoA: 54.2
Ethylmalonyl-CoA: 53.0
2-Methylbutyryl-CoA: 51.7
Isobutyryl-CoA: 47.0
trans-1,2-CPDA: 28.4
3-Methylbutyryl-CoA: 27.6
Benzoyl-CoA: 22.3
fatty_acid: 17.4
Acetyl-CoA: 10.9

ctg1_orf17

Search NORINE for peptide: strict or relaxed

AMP-binding (476..871): X

NRPSPredictor2: gly, ala, val, leu, ile, abu, iva

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic
Large clusters prediction:: gly, ala, val, leu, ile, abu, iva
Small clusters prediction:: N/A
Single AA prediction:: N/A

Stachelhaus prediction details:

Stachelhaus sequence:: DaFVvGvIWK
Nearest Stachelhaus code:: thr
Stachelhaus code match:: 70% (weak)