BGC0001491 - 1 region(s) - antiSMASH results

Identified secondary metabolite regions using strictness 'relaxed'

BGC0001491 (Couchioplanes caeruleus subsp. caeruleus)

Region	Type	From	To	Most similar known cluster		Similarity
Region 1	T1PKS,NRPS-like	1	125,822	candicidin	Polyketide	71%

BGC0001491 - Region 1 - NRPS-like,T1PKS

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Location: 1 - 125,822 nt. (total: 125,822 nt) Show pHMM detection rules used

Region on contig edge.

T1PKS: cds(PKS_AT and (PKS_KS or ene_KS or mod_KS or hyb_KS or itr_KS or tra_KS))
NRPS-like: cds((PP-binding or NAD_binding_4) and (AMP-binding or A-OX))

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core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

TTA codons

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Gene details

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MIBiG

NRPS/PKS domains

MIBiG comparison

KnownClusterBlast

NRPS/PKS modules

External annotation

Name		MIBiG
Version		3.0

Type		Subregion
Location		1 - 125,823
Label		BGC0001491

Detailed domain annotation

Selected features only

Show module domains

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001491.1	1.17	Polyketide	67-121C	Couchioplanes caeruleus subsp. caeruleus
BGC0002031.1	0.66	Alkaloid	kitasetaline	Kitasatospora setae KM-6054
BGC0001068.1	0.57	Terpene, Polyketide	pyripyropene A	unidentified unclassified sequences.
BGC0000138.1	0.55	Polyketide	rimocidin	Streptomyces diastaticus
BGC0001544.1	0.55	NRP, Polyketide	chlorflavonin	Aspergillus campestris IBT 28561
BGC0001858.1	0.54	Polyketide	alternapyrone B, alternapyrone C, alternapyrone D, alternapyrone E, alternapyrone F	Parastagonospora nodorum SN15
BGC0000719.1	0.53	Saccharide	tobramycin	Streptoalloteichus hindustanus
BGC0000120.1	0.49	Polyketide	patulin	Penicillium expansum
BGC0001304.1	0.48	Polyketide	aflavarin	Aspergillus flavus NRRL3357
BGC0001280.1	0.48	Polyketide	betaenone C, betaenone A	Phoma betae

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001491.1	0.95	Polyketide	67-121C	Couchioplanes caeruleus subsp. caeruleus
BGC0002031.1	0.66	Alkaloid	kitasetaline	Kitasatospora setae KM-6054
BGC0000138.1	0.65	Polyketide	rimocidin	Streptomyces diastaticus
BGC0001162.1	0.65	Polyketide	1-heptadecene	Moorea producens JHB
BGC0000120.1	0.65	Polyketide	patulin	Penicillium expansum
BGC0001854.1	0.64	Polyketide	tricholignan A	Trichoderma harzianum
BGC0001901.1	0.64	Polyketide	tricholignan A	Trichoderma harzianum
BGC0001273.1	0.64	Polyketide	asperlactone	Aspergillus ochraceus
BGC0001244.1	0.63	Polyketide	(-)-Mellein	Parastagonospora nodorum
BGC0001304.1	0.63	Polyketide	aflavarin	Aspergillus flavus NRRL3357

Similar known gene clusters

Module view

Legend

NRPS/PKS products

NRPS/PKS monomers

Predicted core structure(s)

For candidate cluster 1, location 0 - 125822:

Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:: (ccmal - ohmal - Me-ohmal - ohmal - mal - ohmal) + (ccmal - ccmal) + (ccmal - ohmal - ccmal) + (ohmal - pk - Me-ccmal) + (ccmal - ccmal - ccmal - ccmal - ccmal - ccmal) + (X - mal)

Direct lookup in NORINE database: strict or relaxed

Link to NORINE database query form

NRPS/PKS monomer predictions

BG844_00045

PKS_AT (552..832): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 87.5%; inactive: 70.8%; Propionyl-CoA: 54.2%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 180.2
inactive: 89.3
Methoxymalonyl-CoA: 57.0
Methylmalonyl-CoA: 44.4
Isobutyryl-CoA: 21.2
Benzoyl-CoA: 18.7
Ethylmalonyl-CoA: 17.9
Acetyl-CoA: 17.3
Propionyl-CoA: 14.7
fatty_acid: 8.1
CHC-CoA: 7.1
trans-1,2-CPDA: 4.3
2-Methylbutyryl-CoA: 3.3
3-Methylbutyryl-CoA: 0.0

PKS_AT (2219..2497): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 91.7%; inactive: 75.0%; Propionyl-CoA: 54.2%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 176.2
inactive: 93.6
Methoxymalonyl-CoA: 57.3
Methylmalonyl-CoA: 45.3
Ethylmalonyl-CoA: 19.9
Isobutyryl-CoA: 18.0
Benzoyl-CoA: 16.0
Propionyl-CoA: 13.5
Acetyl-CoA: 10.5
fatty_acid: 8.1
CHC-CoA: 5.3
trans-1,2-CPDA: 4.1
2-Methylbutyryl-CoA: 3.9
3-Methylbutyryl-CoA: 0.0

PKS_AT (3717..4013): mmal

ATSignature: Methylmalonyl-CoA

Top 3 matches:: Methylmalonyl-CoA: 100.0%; Methoxymalonyl-CoA: 95.8%; Ethylmalonyl-CoA: 91.7%

minowa: Methylmalonyl-CoA

Prediction, score:

Methylmalonyl-CoA: 218.1
Ethylmalonyl-CoA: 210.4
Methoxymalonyl-CoA: 174.4
2-Methylbutyryl-CoA: 144.2
trans-1,2-CPDA: 131.7
Propionyl-CoA: 122.7
CHC-CoA: 107.9
Malonyl-CoA: 106.6
Isobutyryl-CoA: 94.9
Benzoyl-CoA: 72.6
fatty_acid: 39.4
Acetyl-CoA: 38.3
3-Methylbutyryl-CoA: 35.7
inactive: 28.6

PKS_AT (5200..5481): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 91.7%; inactive: 70.8%; Propionyl-CoA: 58.3%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 198.1
inactive: 108.2
Methoxymalonyl-CoA: 56.3
Methylmalonyl-CoA: 44.4
Isobutyryl-CoA: 27.5
Acetyl-CoA: 15.4
Ethylmalonyl-CoA: 10.6
CHC-CoA: 6.3
Benzoyl-CoA: 5.4
Propionyl-CoA: 1.6
trans-1,2-CPDA: 0.0
fatty_acid: 0.0
3-Methylbutyryl-CoA: 0.0
2-Methylbutyryl-CoA: 0.0

PKS_AT (6617..6885): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 91.7%; inactive: 75.0%; Methylmalonyl-CoA: 54.2%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 188.4
inactive: 84.4
Methoxymalonyl-CoA: 59.5
Methylmalonyl-CoA: 49.3
Propionyl-CoA: 27.1
Isobutyryl-CoA: 22.6
Ethylmalonyl-CoA: 20.2
Acetyl-CoA: 15.6
Benzoyl-CoA: 14.5
fatty_acid: 11.6
CHC-CoA: 5.4
2-Methylbutyryl-CoA: 5.3
trans-1,2-CPDA: 0.0
3-Methylbutyryl-CoA: 0.0

PKS_AT (7969..8262): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 95.8%; inactive: 79.2%; Methylmalonyl-CoA: 54.2%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 221.9
inactive: 112.2
Methoxymalonyl-CoA: 68.2
Methylmalonyl-CoA: 59.0
Propionyl-CoA: 28.5
Ethylmalonyl-CoA: 26.7
Isobutyryl-CoA: 24.5
fatty_acid: 22.8
Benzoyl-CoA: 19.0
Acetyl-CoA: 17.0
CHC-CoA: 15.7
2-Methylbutyryl-CoA: 13.2
trans-1,2-CPDA: 10.3
3-Methylbutyryl-CoA: 0.0

BG844_00050

PKS_AT (534..790): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 87.5%; inactive: 70.8%; Methylmalonyl-CoA: 54.2%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 187.2
inactive: 90.5
Methoxymalonyl-CoA: 59.1
Methylmalonyl-CoA: 42.5
Propionyl-CoA: 29.5
Acetyl-CoA: 19.6
Isobutyryl-CoA: 15.8
fatty_acid: 14.9
Benzoyl-CoA: 14.1
Ethylmalonyl-CoA: 13.0
trans-1,2-CPDA: 0.0
CHC-CoA: 0.0
3-Methylbutyryl-CoA: 0.0
2-Methylbutyryl-CoA: 0.0

PKS_AT (2055..2312): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 91.7%; inactive: 79.2%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 198.3
inactive: 99.2
Methoxymalonyl-CoA: 56.6
Methylmalonyl-CoA: 39.8
Isobutyryl-CoA: 21.0
Propionyl-CoA: 19.5
Benzoyl-CoA: 14.7
Acetyl-CoA: 14.6
Ethylmalonyl-CoA: 11.5
fatty_acid: 9.1
trans-1,2-CPDA: 0.0
CHC-CoA: 0.0
3-Methylbutyryl-CoA: 0.0
2-Methylbutyryl-CoA: 0.0

BG844_00055

PKS_AT (536..792): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 91.7%; inactive: 79.2%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 197.1
inactive: 99.5
Methoxymalonyl-CoA: 56.2
Methylmalonyl-CoA: 42.0
Propionyl-CoA: 21.8
Ethylmalonyl-CoA: 17.2
fatty_acid: 16.5
Acetyl-CoA: 16.5
Benzoyl-CoA: 13.4
Isobutyryl-CoA: 10.9
trans-1,2-CPDA: 0.0
CHC-CoA: 0.0
3-Methylbutyryl-CoA: 0.0
2-Methylbutyryl-CoA: 0.0

PKS_AT (2127..2382): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 91.7%; inactive: 79.2%; Methylmalonyl-CoA: 54.2%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 187.8
inactive: 92.8
Methoxymalonyl-CoA: 51.5
Methylmalonyl-CoA: 42.2
Propionyl-CoA: 20.4
Isobutyryl-CoA: 20.3
Benzoyl-CoA: 18.9
Acetyl-CoA: 17.0
fatty_acid: 14.0
Ethylmalonyl-CoA: 10.9
CHC-CoA: 9.5
trans-1,2-CPDA: 0.0
3-Methylbutyryl-CoA: 0.0
2-Methylbutyryl-CoA: 0.0

PKS_AT (3566..3821): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 91.7%; inactive: 79.2%; Methylmalonyl-CoA: 54.2%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 187.8
inactive: 92.8
Methoxymalonyl-CoA: 51.5
Methylmalonyl-CoA: 42.2
Propionyl-CoA: 20.4
Isobutyryl-CoA: 20.3
Benzoyl-CoA: 18.9
Acetyl-CoA: 17.0
fatty_acid: 14.0
Ethylmalonyl-CoA: 10.9
CHC-CoA: 9.5
trans-1,2-CPDA: 0.0
3-Methylbutyryl-CoA: 0.0
2-Methylbutyryl-CoA: 0.0

BG844_00060

PKS_AT (548..816): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 87.5%; inactive: 70.8%; Propionyl-CoA: 54.2%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 167.4
inactive: 74.6
Methoxymalonyl-CoA: 62.2
Methylmalonyl-CoA: 52.8
Ethylmalonyl-CoA: 31.5
Acetyl-CoA: 16.5
Benzoyl-CoA: 16.4
Isobutyryl-CoA: 16.3
Propionyl-CoA: 16.2
trans-1,2-CPDA: 12.2
CHC-CoA: 9.7
2-Methylbutyryl-CoA: 9.2
fatty_acid: 8.6
3-Methylbutyryl-CoA: 0.0

PKS_AT (1916..2209): pk

ATSignature: Methylmalonyl-CoA

Top 3 matches:: Methylmalonyl-CoA: 95.8%; Methoxymalonyl-CoA: 91.7%; Ethylmalonyl-CoA: 87.5%

minowa: Ethylmalonyl-CoA

Prediction, score:

Ethylmalonyl-CoA: 218.1
Methylmalonyl-CoA: 217.2
Methoxymalonyl-CoA: 177.3
2-Methylbutyryl-CoA: 148.2
trans-1,2-CPDA: 134.7
Propionyl-CoA: 104.4
CHC-CoA: 100.1
Malonyl-CoA: 95.1
Isobutyryl-CoA: 88.9
Benzoyl-CoA: 61.5
Acetyl-CoA: 45.3
3-Methylbutyryl-CoA: 44.7
fatty_acid: 43.6
inactive: 33.3

PKS_AT (3897..4190): mmal

ATSignature: Methylmalonyl-CoA

Top 3 matches:: Methylmalonyl-CoA: 100.0%; Methoxymalonyl-CoA: 95.8%; Ethylmalonyl-CoA: 91.7%

minowa: Methylmalonyl-CoA

Prediction, score:

Methylmalonyl-CoA: 212.9
Ethylmalonyl-CoA: 201.9
Methoxymalonyl-CoA: 183.6
2-Methylbutyryl-CoA: 146.2
trans-1,2-CPDA: 139.1
Propionyl-CoA: 116.1
Malonyl-CoA: 103.1
CHC-CoA: 99.7
Isobutyryl-CoA: 84.0
Benzoyl-CoA: 65.9
3-Methylbutyryl-CoA: 49.7
Acetyl-CoA: 44.5
inactive: 38.3
fatty_acid: 23.4

BG844_00065

PKS_AT (561..817): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 91.7%; inactive: 79.2%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 195.7
inactive: 103.2
Methoxymalonyl-CoA: 65.2
Methylmalonyl-CoA: 50.9
Isobutyryl-CoA: 27.0
Benzoyl-CoA: 22.7
Propionyl-CoA: 22.3
fatty_acid: 18.4
Ethylmalonyl-CoA: 16.7
Acetyl-CoA: 15.0
CHC-CoA: 10.5
3-Methylbutyryl-CoA: 6.2
trans-1,2-CPDA: 5.2
2-Methylbutyryl-CoA: 4.6

PKS_AT (2133..2394): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 91.7%; inactive: 75.0%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 186.5
inactive: 97.7
Methoxymalonyl-CoA: 61.9
Methylmalonyl-CoA: 52.1
Propionyl-CoA: 25.5
Isobutyryl-CoA: 23.6
Benzoyl-CoA: 22.1
Ethylmalonyl-CoA: 18.8
Acetyl-CoA: 17.2
fatty_acid: 12.6
CHC-CoA: 9.7
2-Methylbutyryl-CoA: 9.5
trans-1,2-CPDA: 7.7
3-Methylbutyryl-CoA: 0.0

PKS_AT (3717..3978): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 95.8%; inactive: 79.2%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 189.7
inactive: 97.4
Methoxymalonyl-CoA: 61.5
Methylmalonyl-CoA: 46.2
Propionyl-CoA: 25.5
Ethylmalonyl-CoA: 22.6
Benzoyl-CoA: 22.1
Acetyl-CoA: 18.6
Isobutyryl-CoA: 17.8
fatty_acid: 16.7
2-Methylbutyryl-CoA: 14.9
CHC-CoA: 7.8
trans-1,2-CPDA: 7.6
3-Methylbutyryl-CoA: 0.0

PKS_AT (5318..5579): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 91.7%; inactive: 79.2%; Methylmalonyl-CoA: 54.2%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 199.8
inactive: 104.0
Methoxymalonyl-CoA: 62.7
Methylmalonyl-CoA: 49.0
fatty_acid: 24.8
Propionyl-CoA: 24.7
Benzoyl-CoA: 21.3
Isobutyryl-CoA: 19.7
Ethylmalonyl-CoA: 17.9
Acetyl-CoA: 15.1
CHC-CoA: 8.5
2-Methylbutyryl-CoA: 7.6
trans-1,2-CPDA: 0.0
3-Methylbutyryl-CoA: 0.0

PKS_AT (6915..7172): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 91.7%; inactive: 75.0%; Methylmalonyl-CoA: 54.2%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 180.5
inactive: 85.1
Methoxymalonyl-CoA: 59.6
Methylmalonyl-CoA: 48.6
Propionyl-CoA: 32.4
Isobutyryl-CoA: 26.9
Benzoyl-CoA: 20.1
Ethylmalonyl-CoA: 19.4
Acetyl-CoA: 19.4
fatty_acid: 14.4
CHC-CoA: 12.1
2-Methylbutyryl-CoA: 10.9
trans-1,2-CPDA: 7.9
3-Methylbutyryl-CoA: 0.0

PKS_AT (8495..8756): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 91.7%; inactive: 79.2%; Methylmalonyl-CoA: 54.2%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 199.8
inactive: 104.0
Methoxymalonyl-CoA: 62.7
Methylmalonyl-CoA: 49.0
fatty_acid: 24.8
Propionyl-CoA: 24.7
Benzoyl-CoA: 21.3
Isobutyryl-CoA: 19.7
Ethylmalonyl-CoA: 17.9
Acetyl-CoA: 15.1
CHC-CoA: 8.5
2-Methylbutyryl-CoA: 7.6
trans-1,2-CPDA: 0.0
3-Methylbutyryl-CoA: 0.0

BG844_00075

Search NORINE for peptide: strict or relaxed

AMP-binding (29..424): X

NRPSPredictor2: (unknown)

SVM prediction details:

NOTE: outside applicability domain

Predicted physicochemical class:: N/A
Large clusters prediction:: N/A
Small clusters prediction:: N/A
Single AA prediction:: N/A

Stachelhaus prediction details:

Stachelhaus sequence:: Gl-frAVtGK
Nearest Stachelhaus code:: hiv-d
Stachelhaus code match:: 50% (weak)

PKS_AT (1135..1393): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 91.7%; inactive: 70.8%; Methylmalonyl-CoA: 54.2%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 178.8
inactive: 92.2
Methoxymalonyl-CoA: 65.8
Methylmalonyl-CoA: 48.4
Isobutyryl-CoA: 36.5
Propionyl-CoA: 19.6
fatty_acid: 17.8
Benzoyl-CoA: 17.5
Acetyl-CoA: 16.8
Ethylmalonyl-CoA: 14.3
trans-1,2-CPDA: 13.9
CHC-CoA: 13.8
3-Methylbutyryl-CoA: 0.0
2-Methylbutyryl-CoA: 0.0