BGC0001556 - 1 region(s) - antiSMASH results

Identified secondary metabolite regions using strictness 'relaxed'

BGC0001556 (Streptomyces sp)

Region	Type	From	To	Most similar known cluster		Similarity
Region 1	T1PKS,NRPS	1	21,510	SGR PTMs	NRP + Polyketide	66%

BGC0001556 - Region 1 - NRPS,T1PKS

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Location: 1 - 21,510 nt. (total: 21,510 nt) Show pHMM detection rules used

Region on contig edge.

T1PKS: cds(PKS_AT and (PKS_KS or ene_KS or mod_KS or hyb_KS or itr_KS or tra_KS))
NRPS: cds(Condensation and (AMP-binding or A-OX))

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core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

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resistance

TTA codons

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Gene details

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MIBiG

NRPS/PKS domains

MIBiG comparison

KnownClusterBlast

NRPS/PKS modules

External annotation

Name		MIBiG
Version		3.0

Type		Subregion
Location		1 - 21,511
Label		BGC0001556

Detailed domain annotation

Selected features only

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Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001556.1	1.66	NRP, Polyketide	combamide	Streptomyces sp.
BGC0001043.1	0.70	NRP, Polyketide	SGR PTMs	Streptomyces griseus subsp. griseus NBRC 13350
BGC0001615.1	0.64	NRP	hexose-palythine-serine, hexose-shinorine	Heteroscytonema crispum UCFS10
BGC0002075.1	0.61	NRP, Alkaloid	Pyreudione A, Pyreudione B, Pyreudione C, Pyreudione D, Pyreudione E	Pseudomonas fluorescens
BGC0001726.1	0.58	NRP, Polyketide	pactamides	Streptomyces pactum
BGC0001068.1	0.57	Terpene, Polyketide	pyripyropene A	unidentified unclassified sequences.
BGC0000999.1	0.56	NRP, Polyketide	heat-stable antifungal factor	Lysobacter enzymogenes
BGC0001075.1	0.54	Terpene, Polyketide	aurachin RE	Rhodococcus erythropolis
BGC0000046.1	0.53	Polyketide	depudecin	Alternaria brassicicola
BGC0001280.1	0.51	Polyketide	betaenone C, betaenone A	Phoma betae

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001556.1	0.94	NRP, Polyketide	combamide	Streptomyces sp.
BGC0001043.1	0.68	NRP, Polyketide	SGR PTMs	Streptomyces griseus subsp. griseus NBRC 13350
BGC0001615.1	0.66	NRP	hexose-palythine-serine, hexose-shinorine	Heteroscytonema crispum UCFS10
BGC0002075.1	0.64	NRP, Alkaloid	Pyreudione A, Pyreudione B, Pyreudione C, Pyreudione D, Pyreudione E	Pseudomonas fluorescens
BGC0001726.1	0.63	NRP, Polyketide	pactamides	Streptomyces pactum
BGC0001068.1	0.62	Terpene, Polyketide	pyripyropene A	unidentified unclassified sequences.
BGC0000999.1	0.61	NRP, Polyketide	heat-stable antifungal factor	Lysobacter enzymogenes
BGC0001075.1	0.60	Terpene, Polyketide	aurachin RE	Rhodococcus erythropolis
BGC0000046.1	0.60	Polyketide	depudecin	Alternaria brassicicola
BGC0001280.1	0.59	Polyketide	betaenone C, betaenone A	Phoma betae

Similar known gene clusters

Module view

Legend

NRPS/PKS products

NRPS/PKS monomers

Predicted core structure(s)

For candidate cluster 1, location 0 - 21510:

Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:: (pk - orn)

Direct lookup in NORINE database: strict or relaxed

Link to NORINE database query form

NRPS/PKS monomer predictions

cbmA

Search NORINE for peptide: strict or relaxed

PKS_AT (611..912): pk

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 75.0%; CE-Malonyl-CoA: 58.3%; Acetyl-CoA: 58.3%

minowa: Methylmalonyl-CoA

Prediction, score:

Methylmalonyl-CoA: 123.8
Malonyl-CoA: 119.1
Methoxymalonyl-CoA: 118.7
Ethylmalonyl-CoA: 106.5
Isobutyryl-CoA: 101.4
Acetyl-CoA: 81.2
Propionyl-CoA: 68.4
2-Methylbutyryl-CoA: 63.9
trans-1,2-CPDA: 60.9
Benzoyl-CoA: 57.4
CHC-CoA: 48.4
fatty_acid: 44.8
3-Methylbutyryl-CoA: 40.3
inactive: 29.5

AMP-binding (2458..2915): orn

NRPSPredictor2: orn

SVM prediction details:

Predicted physicochemical class:: hydrophilic
Large clusters prediction:: orn, lys, arg
Small clusters prediction:: orn, horn
Single AA prediction:: orn

Stachelhaus prediction details:

Stachelhaus sequence:: DVGEIGSVDK
Nearest Stachelhaus code:: orn
Stachelhaus code match:: 100% (strong)