BGC0000027 - 1 region(s) - antiSMASH results

Identified secondary metabolite regions using strictness 'relaxed'

BGC0000027 (Monascus pilosus)

Region	Type	From	To	Most similar known cluster		Similarity
Region 1	T1PKS	1	80,000	ankaflavin/monascin/rubropunctatine/monascorubrin	PKS:Iterative type I	100%

BGC0000027 - Region 1 - T1PKS

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Location: 1 - 80,000 nt. (total: 80,000 nt) Show pHMM detection rules used

Region on contig edge.

T1PKS: cds(PKS_AT and (PKS_KS or ene_KS or mod_KS or hyb_KS or itr_KS or tra_KS))

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core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

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Gene details

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Gene overview

MIBiG

NRPS/PKS domains

MIBiG comparison

KnownClusterBlast

NRPS/PKS modules

Gene/CDS overview

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Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

External annotation

Name		MIBiG
Version		4.0alpha

Type		Subregion
Location		1 - 80,001
Label		BGC0000027

Detailed domain annotation

Selected features only

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Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000027	0.82	Polyketide	ankaflavin, monascin, rubropunctatine, monascorubrin	Monascus pilosus
BGC0000099	0.44	Polyketide	monascorubrin	Talaromyces marneffei
BGC0002429	0.32	Terpene, Polyketide	higginsianin B	Colletotrichum higginsianum IMI 349063
BGC0001976	0.28	Terpene	eupenifeldin	Phoma sp.
BGC0000894	0.27	Other	citrinin	Monascus aurantiacus
BGC0002483	0.26	Polyketide	usnic acid	Cladonia uncialis subsp. uncialis
BGC0002427	0.26	Terpene, Polyketide	subglutinol A, subglutinol B	Metarhizium robertsii ARSEF 23
BGC0002603	0.23	Polyketide	chevalone E	Aspergillus versicolor
BGC0000156	0.22	Polyketide	TAN-1612, 1-(2,3,5,10-tetrahydroxy-7-methoxy-4-oxo-1,2,3,4-tetrahydroanthracen-2-yl)pentane-2,4-dione, desmethyl TAN-1612	Aspergillus niger
BGC0001616	0.22	NRP, Polyketide	himeic acid A	Aspergillus japonicus

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000027	1.00	Polyketide	ankaflavin, monascin, rubropunctatine, monascorubrin	Monascus pilosus
BGC0000099	0.74	Polyketide	monascorubrin	Talaromyces marneffei
BGC0002429	0.66	Terpene, Polyketide	higginsianin B	Colletotrichum higginsianum IMI 349063
BGC0000894	0.61	Other	citrinin	Monascus aurantiacus
BGC0002483	0.59	Polyketide	usnic acid	Cladonia uncialis subsp. uncialis
BGC0002603	0.56	Polyketide	chevalone E	Aspergillus versicolor
BGC0000156	0.55	Polyketide	TAN-1612, 1-(2,3,5,10-tetrahydroxy-7-methoxy-4-oxo-1,2,3,4-tetrahydroanthracen-2-yl)pentane-2,4-dione, desmethyl TAN-1612	Aspergillus niger
BGC0001616	0.55	NRP, Polyketide	himeic acid A	Aspergillus japonicus
BGC0001886	0.54	Polyketide	secalonic acids	Claviceps purpurea 20.1
BGC0001219	0.54	Polyketide	shanorellin	Chaetomium globosum CBS 148.51

Similar known gene clusters from MIBiG 4.0

Module view

Legend

NRPS/PKS products

NRPS/PKS substrates

Predicted core structure(s)

For candidate cluster 1, location 0 - 42056:

Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:: (pk)

Direct lookup in NORINE database: strict or relaxed

Link to NORINE database query form

NRPS/PKS substrate predictions

2362MpPKS5

PKS_AT (913..1204): pk

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 66.7%; Ethylmalonyl-CoA: 54.2%; Methylmalonyl-CoA: 54.2%

minowa: Methoxymalonyl-CoA

Prediction, score:

Methoxymalonyl-CoA: 55.3
inactive: 54.1
Malonyl-CoA: 49.4
Methylmalonyl-CoA: 43.3
Propionyl-CoA: 25.2
CHC-CoA: 23.0
Ethylmalonyl-CoA: 22.4
2-Methylbutyryl-CoA: 19.3
Acetyl-CoA: 16.6
trans-1,2-CPDA: 14.3
Isobutyryl-CoA: 14.1
fatty_acid: 14.0
3-Methylbutyryl-CoA: 13.2
Benzoyl-CoA: 12.2

2372MpFasB2

PKS_AT (1645..1839): pk

ATSignature: (unknown)

No matches above 50%

minowa: trans-1,2-CPDA

Prediction, score:

trans-1,2-CPDA: 0.0
inactive: 0.0
fatty_acid: 0.0
Propionyl-CoA: 0.0
Methylmalonyl-CoA: 0.0
Methoxymalonyl-CoA: 0.0
Malonyl-CoA: 0.0
Isobutyryl-CoA: 0.0
Ethylmalonyl-CoA: 0.0
CHC-CoA: 0.0
Benzoyl-CoA: 0.0
Acetyl-CoA: 0.0
3-Methylbutyryl-CoA: 0.0
2-Methylbutyryl-CoA: 0.0