BGC0000027 - 1 region(s) - antiSMASH results

Identified secondary metabolite regions using strictness 'relaxed'

BGC0000027 (Monascus pilosus)

Region	Type	From	To	Similarity Confidence	Most similar known cluster
Region 1	T1PKS	1	80,000	High	ankaflavin/monascin/rubropunctatine/monascorubrin	PKS:Iterative type I

BGC0000027 - Region 1 - T1PKS

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Location: 1 - 80,000 nt. (total: 80,000 nt) Show pHMM detection rules used

Region on contig edge.

T1PKS: cds(PKS_AT and (PKS_KS or ene_KS or mod_KS or hyb_KS or itr_KS or tra_KS))

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core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

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Gene details

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Gene overview

MIBiG

Tailoring

MIBiG comparison

KnownClusterBlast

NRPS/PKS modules

NRPS/PKS domains

Gene/CDS overview

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Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

External annotation

Name		MIBiG
Version		4.0alpha

Type		Subregion
Location		1 - 80,001
Label		BGC0000027

Tailoring functions

Oxidoreductases: dehydrogenase oxidoreductase

2364A: short-chain dehydrogenase/reductase SDR

smcogs: SMCOG1001: short-chain dehydrogenase/reductase SDR

2366C: aldo/keto reductase family oxidoreductase

smcogs: SMCOG1039: aldo/keto reductase family oxidoreductase

2368E: crotonyl-CoA reductase / alcohol dehydrogenase

smcogs: SMCOG1028: crotonyl-CoA reductase / alcohol dehydrogenase

Transferases: acylase

2372MpFasB2: malonyl CoA-acyl carrier protein transacylase

smcogs: SMCOG1021: malonyl CoA-acyl carrier protein transacylase

Ligases: synthase

2362MpPKS5: Beta-ketoacyl synthase

smcogs: SMCOG1022: Beta-ketoacyl synthase

2371MpFasA2: Beta-ketoacyl synthase

smcogs: SMCOG1022: Beta-ketoacyl synthase

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000027.4	0.93	PKS	ankaflavin, monascin, rubropunctatine, monascorubrin	Monascus pilosus
BGC0001273.3	0.66	PKS	asperlactone	Aspergillus ochraceus
BGC0002191.2	0.66	PKS	prolipyrone B, gibepyrone D	Fusarium graminearum PH-1
BGC0001244.3	0.65	PKS	(-)-Mellein	Parastagonospora nodorum
BGC0001276.3	0.65	PKS	6-methylsalicyclic acid	Aspergillus terreus
BGC0000037.4	0.64	PKS	cichorine	Aspergillus nidulans FGSC A4
BGC0001254.3	0.64	PKS	ACT-Toxin II	Alternaria alternata
BGC0001257.3	0.62	PKS	1,3,6,8-tetrahydroxynaphthalene	Nodulisporium sp. ATCC74245
BGC0001258.3	0.62	PKS	1,3,6,8-tetrahydroxynaphthalene	Glarea lozoyensis
BGC0001164.3	0.62	PKS	1-heptadecene	Cyanothece sp. PCC 7822

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000027.4	1.00	PKS	ankaflavin, monascin, rubropunctatine, monascorubrin	Monascus pilosus
BGC0001273.3	0.66	PKS	asperlactone	Aspergillus ochraceus
BGC0002191.2	0.66	PKS	prolipyrone B, gibepyrone D	Fusarium graminearum PH-1
BGC0001244.3	0.65	PKS	(-)-Mellein	Parastagonospora nodorum
BGC0001276.3	0.65	PKS	6-methylsalicyclic acid	Aspergillus terreus
BGC0000037.4	0.64	PKS	cichorine	Aspergillus nidulans FGSC A4
BGC0001254.3	0.64	PKS	ACT-Toxin II	Alternaria alternata
BGC0001257.3	0.62	PKS	1,3,6,8-tetrahydroxynaphthalene	Nodulisporium sp. ATCC74245
BGC0001258.3	0.62	PKS	1,3,6,8-tetrahydroxynaphthalene	Glarea lozoyensis
BGC0001164.3	0.62	PKS	1-heptadecene	Cyanothece sp. PCC 7822

Similar known clusters from MIBiG 4.0

Module view

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Detailed domain annotation

Selected features only

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NRPS/PKS products

NRPS/PKS substrates

Predicted core structure(s)

For candidate cluster 1, location 0 - 42056:

Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:: (pk)

Direct lookup in NORINE database: strict or relaxed

Link to NORINE database query form

NRPS/PKS substrate predictions

2362MpPKS5: pk

PKS_AT (913..1204): pk

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 66.7%; Ethylmalonyl-CoA: 54.2%; Methylmalonyl-CoA: 54.2%

minowa: Methoxymalonyl-CoA

Prediction, score:

Methoxymalonyl-CoA: 55.3
inactive: 54.1
Malonyl-CoA: 49.4
Methylmalonyl-CoA: 43.3
Propionyl-CoA: 25.2
CHC-CoA: 23.0
Ethylmalonyl-CoA: 22.4
2-Methylbutyryl-CoA: 19.3
Acetyl-CoA: 16.6
trans-1,2-CPDA: 14.3
Isobutyryl-CoA: 14.1
fatty_acid: 14.0
3-Methylbutyryl-CoA: 13.2
Benzoyl-CoA: 12.2

2372MpFasB2: pk

PKS_AT (1645..1839): pk

ATSignature: (unknown)

No matches above 50%

minowa: trans-1,2-CPDA

Prediction, score:

trans-1,2-CPDA: 0.0
inactive: 0.0
fatty_acid: 0.0
Propionyl-CoA: 0.0
Methylmalonyl-CoA: 0.0
Methoxymalonyl-CoA: 0.0
Malonyl-CoA: 0.0
Isobutyryl-CoA: 0.0
Ethylmalonyl-CoA: 0.0
CHC-CoA: 0.0
Benzoyl-CoA: 0.0
Acetyl-CoA: 0.0
3-Methylbutyryl-CoA: 0.0
2-Methylbutyryl-CoA: 0.0

Link to PARAS substrate predictor