BGC0000055 - 1 region(s) - antiSMASH results

Identified secondary metabolite regions using strictness 'relaxed'

BGC0000055 (Saccharopolyspora erythraea NRRL 2338)

Region	Type	From	To	Most similar known cluster		Similarity
Region 1	T1PKS	1	54,612	erythromycin	Polyketide	64%

BGC0000055 - Region 1 - T1PKS

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Location: 1 - 54,612 nt. (total: 54,612 nt) Show pHMM detection rules used

Region on contig edge.

T1PKS: cds(PKS_AT and (PKS_KS or ene_KS or mod_KS or hyb_KS or itr_KS or tra_KS))

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core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

TTA codons

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Gene details

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MIBiG

NRPS/PKS domains

MIBiG comparison

KnownClusterBlast

NRPS/PKS modules

External annotation

Name		MIBiG
Version		3.0

Type		Subregion
Location		1 - 54,613
Label		BGC0000055

Detailed domain annotation

Selected features only

Show module domains

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000055.1	0.77	Polyketide, Saccharide	erythromycin A, erythromycin B, erythromycin C, erythromycin D	Saccharopolyspora erythraea NRRL 2338
BGC0000041.1	0.33	Polyketide	oronofacic acid	Pseudomonas syringae
BGC0002031.1	0.32	Alkaloid	kitasetaline	Kitasatospora setae KM-6054
BGC0001892.1	0.29	Polyketide	botcinic acid	Botrytis cinerea B05.10
BGC0001141.1	0.28	Polyketide	4-epi-15-epi-brefeldin A	Penicillium brefeldianum
BGC0000067.1	0.27	Polyketide	geldanamycin	Streptomyces hygroscopicus subsp. duamyceticus
BGC0001164.1	0.27	Polyketide	1-heptadecene	Cyanothece sp. PCC 7822
BGC0001062.1	0.27	Polyketide	TLN-05220	Micromonospora echinospora subsp. challisensis
BGC0000719.1	0.26	Saccharide	tobramycin	Streptoalloteichus hindustanus
BGC0000651.1	0.25	Terpene	KS-505a	Streptomyces argenteolus

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000055.1	0.92	Polyketide, Saccharide	erythromycin A, erythromycin B, erythromycin C, erythromycin D	Saccharopolyspora erythraea NRRL 2338
BGC0000041.1	0.66	Polyketide	oronofacic acid	Pseudomonas syringae
BGC0002031.1	0.65	Alkaloid	kitasetaline	Kitasatospora setae KM-6054
BGC0001892.1	0.62	Polyketide	botcinic acid	Botrytis cinerea B05.10
BGC0001141.1	0.62	Polyketide	4-epi-15-epi-brefeldin A	Penicillium brefeldianum
BGC0000067.1	0.61	Polyketide	geldanamycin	Streptomyces hygroscopicus subsp. duamyceticus
BGC0001164.1	0.61	Polyketide	1-heptadecene	Cyanothece sp. PCC 7822
BGC0001062.1	0.61	Polyketide	TLN-05220	Micromonospora echinospora subsp. challisensis
BGC0000719.1	0.59	Saccharide	tobramycin	Streptoalloteichus hindustanus
BGC0000651.1	0.58	Terpene	KS-505a	Streptomyces argenteolus

Similar known gene clusters

Module view

Legend

NRPS/PKS products

NRPS/PKS monomers

Predicted core structure(s)

For candidate cluster 1, location 0 - 54612:

Rough prediction of core scaffold based on assumed PKS linker matching; tailoring reactions not taken into account

Polymer prediction:: (pk - Me-ohmal - Me-ohmal) + (Me-ohmal - Me-redmal) + (Me-ohmal - Me-ohmal)
Non-colinear ordering:: SACE_0721 + SACE_0723 + SACE_0724

Direct lookup in NORINE database: strict or relaxed

Link to NORINE database query form

NRPS/PKS monomer predictions

SACE_0721

PKS_AT (110..404): pk

ATSignature: Propionyl-CoA

Top 3 matches:: Propionyl-CoA: 100.0%; 2-Methylbutyryl-CoA: 79.2%; Methylmalonyl-CoA: 70.8%

minowa: Propionyl-CoA

Prediction, score:

Propionyl-CoA: 229.4
2-Methylbutyryl-CoA: 182.9
Methylmalonyl-CoA: 140.2
Ethylmalonyl-CoA: 126.8
Methoxymalonyl-CoA: 117.9
CHC-CoA: 92.1
trans-1,2-CPDA: 86.4
Malonyl-CoA: 73.7
Acetyl-CoA: 51.1
fatty_acid: 46.2
Isobutyryl-CoA: 41.8
Benzoyl-CoA: 31.9
3-Methylbutyryl-CoA: 26.4
inactive: 22.0

PKS_AT (1085..1386): mmal

ATSignature: Methylmalonyl-CoA

Top 3 matches:: Methylmalonyl-CoA: 100.0%; Methoxymalonyl-CoA: 95.8%; Ethylmalonyl-CoA: 91.7%

minowa: Methylmalonyl-CoA

Prediction, score:

Methylmalonyl-CoA: 218.9
Ethylmalonyl-CoA: 207.0
Methoxymalonyl-CoA: 181.8
2-Methylbutyryl-CoA: 138.0
trans-1,2-CPDA: 125.3
Propionyl-CoA: 118.8
Malonyl-CoA: 102.2
CHC-CoA: 82.9
Isobutyryl-CoA: 77.6
Benzoyl-CoA: 59.9
Acetyl-CoA: 51.0
fatty_acid: 44.9
3-Methylbutyryl-CoA: 35.0
inactive: 31.7

PKS_AT (2563..2861): mmal

ATSignature: Methylmalonyl-CoA

Top 3 matches:: Methylmalonyl-CoA: 100.0%; Methoxymalonyl-CoA: 95.8%; Ethylmalonyl-CoA: 91.7%

minowa: Methylmalonyl-CoA

Prediction, score:

Methylmalonyl-CoA: 212.3
Ethylmalonyl-CoA: 207.3
Methoxymalonyl-CoA: 168.2
2-Methylbutyryl-CoA: 151.4
trans-1,2-CPDA: 116.0
Propionyl-CoA: 115.1
Malonyl-CoA: 100.9
CHC-CoA: 95.8
Isobutyryl-CoA: 69.9
Benzoyl-CoA: 63.1
Acetyl-CoA: 40.3
3-Methylbutyryl-CoA: 35.9
fatty_acid: 23.1
inactive: 21.3

SACE_0723

PKS_AT (561..860): mmal

ATSignature: Methylmalonyl-CoA

Top 3 matches:: Methylmalonyl-CoA: 100.0%; Methoxymalonyl-CoA: 95.8%; Ethylmalonyl-CoA: 91.7%

minowa: Methylmalonyl-CoA

Prediction, score:

Methylmalonyl-CoA: 208.8
Ethylmalonyl-CoA: 200.7
Methoxymalonyl-CoA: 170.0
2-Methylbutyryl-CoA: 135.5
trans-1,2-CPDA: 112.4
Malonyl-CoA: 100.4
Propionyl-CoA: 98.1
CHC-CoA: 89.1
Isobutyryl-CoA: 81.7
Benzoyl-CoA: 66.6
inactive: 45.7
Acetyl-CoA: 41.4
3-Methylbutyryl-CoA: 39.3
fatty_acid: 25.9

PKS_AT (2015..2311): mmal

ATSignature: Methylmalonyl-CoA

Top 3 matches:: Methylmalonyl-CoA: 100.0%; Methoxymalonyl-CoA: 91.7%; Ethylmalonyl-CoA: 83.3%

minowa: Methylmalonyl-CoA

Prediction, score:

Methylmalonyl-CoA: 211.9
Ethylmalonyl-CoA: 190.4
Methoxymalonyl-CoA: 170.2
2-Methylbutyryl-CoA: 140.0
trans-1,2-CPDA: 121.2
Propionyl-CoA: 100.9
Malonyl-CoA: 92.3
CHC-CoA: 81.0
Isobutyryl-CoA: 78.4
Benzoyl-CoA: 61.9
Acetyl-CoA: 58.7
inactive: 35.5
fatty_acid: 35.2
3-Methylbutyryl-CoA: 26.7

SACE_0724

PKS_AT (555..852): mmal

ATSignature: Methylmalonyl-CoA

Top 3 matches:: Methylmalonyl-CoA: 100.0%; Methoxymalonyl-CoA: 95.8%; Ethylmalonyl-CoA: 91.7%

minowa: Methylmalonyl-CoA

Prediction, score:

Methylmalonyl-CoA: 216.1
Ethylmalonyl-CoA: 206.8
Methoxymalonyl-CoA: 173.9
2-Methylbutyryl-CoA: 144.5
trans-1,2-CPDA: 129.9
Propionyl-CoA: 111.3
Malonyl-CoA: 105.3
CHC-CoA: 99.0
Isobutyryl-CoA: 98.0
Benzoyl-CoA: 84.1
Acetyl-CoA: 62.6
3-Methylbutyryl-CoA: 47.4
fatty_acid: 42.6
inactive: 31.6

PKS_AT (2018..2309): mmal

ATSignature: Methylmalonyl-CoA

Top 3 matches:: Methylmalonyl-CoA: 100.0%; Methoxymalonyl-CoA: 95.8%; Ethylmalonyl-CoA: 91.7%

minowa: Methylmalonyl-CoA

Prediction, score:

Methylmalonyl-CoA: 211.2
Ethylmalonyl-CoA: 202.8
Methoxymalonyl-CoA: 174.6
2-Methylbutyryl-CoA: 140.8
Malonyl-CoA: 120.1
trans-1,2-CPDA: 120.0
Propionyl-CoA: 106.2
CHC-CoA: 90.8
Isobutyryl-CoA: 67.3
Benzoyl-CoA: 53.1
Acetyl-CoA: 37.5
fatty_acid: 33.5
inactive: 28.5
3-Methylbutyryl-CoA: 21.1