BGC0000093 - 1 region(s) - antiSMASH results

Identified secondary metabolite regions using strictness 'relaxed'

BGC0000093 (Streptomyces nanchangensis)

Region	Type	From	To	Most similar known cluster		Similarity
Region 1	T1PKS	1	185,250	meilingmycin/Meilingmycin A/Meilingmycin B/Meilingmycin E/Meilingmycin D/Meilingmycin C	PKS:Type I	100%

BGC0000093 - Region 1 - T1PKS

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Location: 1 - 185,250 nt. (total: 185,250 nt) Show pHMM detection rules used

Region on contig edge.

T1PKS: cds(PKS_AT and (PKS_KS or ene_KS or mod_KS or hyb_KS or itr_KS or tra_KS))

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core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

TTA codons

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Gene details

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Gene overview

MIBiG

NRPS/PKS domains

MIBiG comparison

KnownClusterBlast

NRPS/PKS modules

Gene/CDS overview

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Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

External annotation

Name		MIBiG
Version		4.0alpha

Type		Subregion
Location		1 - 185,251
Label		BGC0000093

Detailed domain annotation

Selected features only

Show module domains

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000093	1.04	Polyketide	meilingmycin	Streptomyces nanchangensis
BGC0000041	0.84	Polyketide	oronofacic acid	Pseudomonas syringae
BGC0001544	0.74	NRP, Polyketide	chlorflavonin	Aspergillus campestris IBT 28561
BGC0001163	0.71	Polyketide	1-heptadecene	Moorea producens 3L
BGC0000143	0.61	Polyketide	salinomycin	Streptomyces albus
BGC0000197	0.61	Polyketide, Saccharide	aranciamycin	Streptomyces echinatus
BGC0001162	0.60	Polyketide	1-heptadecene	Moorea producens JHB
BGC0001161	0.60	Polyketide	1-heptadecene	Moorea bouillonii PNG
BGC0000122	0.59	Polyketide	phenylnannolone A, phenylnannolone B, phenylnannolone C	Nannocystis pusilla
BGC0000353	0.57	NRP	tacrolimus	Streptomyces sp. MA6548

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000093	1.00	Polyketide	meilingmycin	Streptomyces nanchangensis
BGC0000041	0.69	Polyketide	oronofacic acid	Pseudomonas syringae
BGC0000677	0.69	Terpene	cyclooctatin	Streptomyces melanosporofaciens
BGC0000249	0.68	Polyketide	nogalamycin	Streptomyces nogalater
BGC0002476	0.67	NRP	enterobactin	Escherichia coli str. K-12 substr. MG1655
BGC0000706	0.67	Saccharide	kanamycin	Streptomyces kanamyceticus
BGC0001164	0.66	Polyketide	1-heptadecene	Cyanothece sp. PCC 7822
BGC0001163	0.66	Polyketide	1-heptadecene	Moorea producens 3L
BGC0002631	0.66	RiPP	myxarylin	Pyxidicoccus fallax
BGC0001587	0.65	Other	ethylenediaminesuccinic acid hydroxyarginine (EDHA)	Streptomyces avermitilis MA-4680 = NBRC 14893

Similar known gene clusters from MIBiG 4.0

Module view

Legend

NRPS/PKS products

NRPS/PKS substrates

Predicted core structure(s)

For candidate cluster 1, location 0 - 116074:

Rough prediction of core scaffold based on assumed PKS linker matching; tailoring reactions not taken into account

Polymer prediction:: (mal - ohmal) + (Me-ccmal) + (mal - ohmal - ohmal - Me-ccmal) + (ohmal - Me-ohmal - ccmal) + (Me-redmal - ccmal - Me-ccmal)
Non-colinear ordering:: pks1 + pks2 + meiA2 + meiA4 + meiA3

Direct lookup in NORINE database: strict or relaxed

For candidate cluster 2, location 0 - 37425:

Rough prediction of core scaffold based on assumed PKS linker matching; tailoring reactions not taken into account

Polymer prediction:: (mal - ohmal) + (Me-ccmal)
Non-colinear ordering:: pks1 + pks2

Direct lookup in NORINE database: strict or relaxed

For candidate cluster 3, location 19451 - 116074:

Rough prediction of core scaffold based on assumed PKS linker matching; tailoring reactions not taken into account

Polymer prediction:: (mal - ohmal - ohmal - Me-ccmal) + (Me-redmal - ccmal - Me-ccmal) + (ohmal - Me-ohmal - ccmal)
Non-colinear ordering:: meiA2 + meiA3 + meiA4

Direct lookup in NORINE database: strict or relaxed

For candidate cluster 4, location 134051 - 185250:

Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:: (Me-mal - Me-ohmal - redmal)

Direct lookup in NORINE database: strict or relaxed

Link to NORINE database query form

NRPS/PKS substrate predictions

pks2

PKS_AT (543..834): mmal

ATSignature: Methylmalonyl-CoA

Top 3 matches:: Methylmalonyl-CoA: 100.0%; Malonyl-CoA: 87.5%; Methoxymalonyl-CoA: 87.5%

minowa: Methylmalonyl-CoA

Prediction, score:

Methylmalonyl-CoA: 188.1
Ethylmalonyl-CoA: 180.0
Methoxymalonyl-CoA: 162.9
2-Methylbutyryl-CoA: 137.0
trans-1,2-CPDA: 125.3
Propionyl-CoA: 97.1
Malonyl-CoA: 95.6
CHC-CoA: 90.1
Isobutyryl-CoA: 77.9
Benzoyl-CoA: 61.6
fatty_acid: 26.9
Acetyl-CoA: 25.7
inactive: 23.4
3-Methylbutyryl-CoA: 16.2

pks1

PKS_AT (366..661): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 66.7%; inactive: 54.2%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 113.4
Methylmalonyl-CoA: 37.4
inactive: 37.2
Methoxymalonyl-CoA: 34.3
Propionyl-CoA: 16.8
Ethylmalonyl-CoA: 14.7
Acetyl-CoA: 13.5
Isobutyryl-CoA: 13.3
Benzoyl-CoA: 11.3
trans-1,2-CPDA: 0.0
fatty_acid: 0.0
CHC-CoA: 0.0
3-Methylbutyryl-CoA: 0.0
2-Methylbutyryl-CoA: 0.0

PKS_AT (1339..1625): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 91.7%; inactive: 70.8%; Methylmalonyl-CoA: 58.3%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 208.9
inactive: 105.9
Methoxymalonyl-CoA: 67.6
Methylmalonyl-CoA: 47.2
Propionyl-CoA: 30.7
fatty_acid: 20.5
Isobutyryl-CoA: 16.6
2-Methylbutyryl-CoA: 16.5
Ethylmalonyl-CoA: 16.4
Acetyl-CoA: 16.3
CHC-CoA: 11.5
Benzoyl-CoA: 11.2
3-Methylbutyryl-CoA: 10.1
trans-1,2-CPDA: 0.0

ADC45517.1

CAL_domain (151..473): pk

minowa: NH2

Prediction, score:

NH2: 67.4
fatty_acid: 19.9
Acetyl-CoA: 14.7
shikimic_acid: 0.0
AHBA: 0.0

meiA2

PKS_AT (564..850): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 87.5%; inactive: 66.7%; Isobutyryl-CoA: 54.2%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 164.3
Methoxymalonyl-CoA: 66.6
inactive: 62.0
Methylmalonyl-CoA: 50.8
Ethylmalonyl-CoA: 23.8
Acetyl-CoA: 22.3
Isobutyryl-CoA: 19.1
Propionyl-CoA: 18.4
Benzoyl-CoA: 15.1
fatty_acid: 12.7
CHC-CoA: 11.6
2-Methylbutyryl-CoA: 11.5
trans-1,2-CPDA: 6.9
3-Methylbutyryl-CoA: 0.0

PKS_AT (1576..1862): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 87.5%; inactive: 66.7%; Isobutyryl-CoA: 54.2%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 165.2
Methoxymalonyl-CoA: 67.1
inactive: 60.8
Methylmalonyl-CoA: 51.1
Ethylmalonyl-CoA: 25.0
Acetyl-CoA: 23.2
Propionyl-CoA: 19.5
Isobutyryl-CoA: 19.4
fatty_acid: 14.7
Benzoyl-CoA: 14.6
2-Methylbutyryl-CoA: 11.9
CHC-CoA: 11.4
trans-1,2-CPDA: 9.5
3-Methylbutyryl-CoA: 0.0

PKS_AT (3111..3397): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 83.3%; inactive: 62.5%; Isobutyryl-CoA: 54.2%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 160.4
Methoxymalonyl-CoA: 65.8
inactive: 59.4
Methylmalonyl-CoA: 49.4
Acetyl-CoA: 26.4
Ethylmalonyl-CoA: 26.2
Propionyl-CoA: 23.5
Isobutyryl-CoA: 22.0
fatty_acid: 19.9
CHC-CoA: 13.2
2-Methylbutyryl-CoA: 13.0
Benzoyl-CoA: 11.3
trans-1,2-CPDA: 8.1
3-Methylbutyryl-CoA: 0.0

PKS_AT (4626..4924): mmal

ATSignature: Methylmalonyl-CoA

Top 3 matches:: Methylmalonyl-CoA: 95.8%; Methoxymalonyl-CoA: 87.5%; Ethylmalonyl-CoA: 83.3%

minowa: Methylmalonyl-CoA

Prediction, score:

Methylmalonyl-CoA: 194.0
Ethylmalonyl-CoA: 180.2
Methoxymalonyl-CoA: 167.5
2-Methylbutyryl-CoA: 138.9
trans-1,2-CPDA: 115.5
Propionyl-CoA: 111.5
Malonyl-CoA: 100.5
CHC-CoA: 94.6
Isobutyryl-CoA: 71.0
Benzoyl-CoA: 52.0
inactive: 38.4
Acetyl-CoA: 33.3
fatty_acid: 22.6
3-Methylbutyryl-CoA: 13.5

meiA4

PKS_AT (571..872): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 95.8%; inactive: 79.2%; 2-Rhyd-Malonyl-CoA: 62.5%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 224.7
inactive: 112.6
Methoxymalonyl-CoA: 64.3
Methylmalonyl-CoA: 52.8
Isobutyryl-CoA: 31.6
Propionyl-CoA: 30.6
Benzoyl-CoA: 30.5
Ethylmalonyl-CoA: 24.9
Acetyl-CoA: 18.0
2-Methylbutyryl-CoA: 13.6
fatty_acid: 13.0
trans-1,2-CPDA: 10.2
CHC-CoA: 6.7
3-Methylbutyryl-CoA: 0.0

PKS_AT (2121..2419): mmal

ATSignature: Methylmalonyl-CoA

Top 3 matches:: Methylmalonyl-CoA: 95.8%; Methoxymalonyl-CoA: 91.7%; Ethylmalonyl-CoA: 87.5%

minowa: Methylmalonyl-CoA

Prediction, score:

Methylmalonyl-CoA: 191.3
Ethylmalonyl-CoA: 189.3
Methoxymalonyl-CoA: 165.1
2-Methylbutyryl-CoA: 134.1
CHC-CoA: 105.9
trans-1,2-CPDA: 105.5
Malonyl-CoA: 99.1
Isobutyryl-CoA: 95.0
Propionyl-CoA: 89.9
Benzoyl-CoA: 53.5
3-Methylbutyryl-CoA: 48.7
Acetyl-CoA: 43.2
fatty_acid: 42.6
inactive: 25.0

PKS_AT (3649..3936): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 87.5%; inactive: 75.0%; 2-Rhyd-Malonyl-CoA: 54.2%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 200.5
inactive: 89.2
Methoxymalonyl-CoA: 61.3
Methylmalonyl-CoA: 48.9
Isobutyryl-CoA: 35.8
Ethylmalonyl-CoA: 25.5
Propionyl-CoA: 23.8
Acetyl-CoA: 19.2
Benzoyl-CoA: 17.7
CHC-CoA: 13.6
2-Methylbutyryl-CoA: 13.1
fatty_acid: 12.8
trans-1,2-CPDA: 0.0
3-Methylbutyryl-CoA: 0.0

meiA3

PKS_AT (589..887): mmal

ATSignature: Methylmalonyl-CoA

Top 3 matches:: Methylmalonyl-CoA: 100.0%; Methoxymalonyl-CoA: 91.7%; Ethylmalonyl-CoA: 87.5%

minowa: Methylmalonyl-CoA

Prediction, score:

Methylmalonyl-CoA: 207.8
Ethylmalonyl-CoA: 201.4
Methoxymalonyl-CoA: 173.3
trans-1,2-CPDA: 152.4
2-Methylbutyryl-CoA: 138.1
Malonyl-CoA: 116.5
Propionyl-CoA: 111.6
CHC-CoA: 91.4
Isobutyryl-CoA: 80.1
Benzoyl-CoA: 67.5
Acetyl-CoA: 42.9
3-Methylbutyryl-CoA: 36.0
inactive: 35.8
fatty_acid: 21.7

PKS_AT (2698..2984): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 87.5%; inactive: 66.7%; Isobutyryl-CoA: 54.2%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 166.8
Methoxymalonyl-CoA: 67.3
inactive: 62.3
Methylmalonyl-CoA: 51.8
Ethylmalonyl-CoA: 24.9
Acetyl-CoA: 24.1
Isobutyryl-CoA: 20.8
Propionyl-CoA: 20.4
fatty_acid: 15.1
Benzoyl-CoA: 15.0
CHC-CoA: 11.5
2-Methylbutyryl-CoA: 11.4
trans-1,2-CPDA: 6.7
3-Methylbutyryl-CoA: 0.0

PKS_AT (4491..4789): mmal

ATSignature: Methylmalonyl-CoA

Top 3 matches:: Methylmalonyl-CoA: 95.8%; Methoxymalonyl-CoA: 87.5%; Ethylmalonyl-CoA: 83.3%

minowa: Methylmalonyl-CoA

Prediction, score:

Methylmalonyl-CoA: 194.0
Ethylmalonyl-CoA: 180.2
Methoxymalonyl-CoA: 167.5
2-Methylbutyryl-CoA: 138.9
trans-1,2-CPDA: 115.5
Propionyl-CoA: 111.5
Malonyl-CoA: 100.5
CHC-CoA: 94.6
Isobutyryl-CoA: 71.0
Benzoyl-CoA: 52.0
inactive: 38.4
Acetyl-CoA: 33.3
fatty_acid: 22.6
3-Methylbutyryl-CoA: 13.5

meiA1

PKS_AT (93..391): mmal

ATSignature: 2-Methylbutyryl-CoA

Top 3 matches:: 2-Methylbutyryl-CoA: 70.8%; Methylmalonyl-CoA: 62.5%; Isobutyryl-CoA: 62.5%

minowa: Methylmalonyl-CoA

Prediction, score:

Methylmalonyl-CoA: 155.4
Ethylmalonyl-CoA: 153.8
2-Methylbutyryl-CoA: 140.2
Methoxymalonyl-CoA: 130.8
trans-1,2-CPDA: 115.2
Propionyl-CoA: 98.5
CHC-CoA: 93.8
Malonyl-CoA: 63.7
Acetyl-CoA: 57.7
Benzoyl-CoA: 53.7
Isobutyryl-CoA: 53.0
3-Methylbutyryl-CoA: 23.1
fatty_acid: 15.8
inactive: 10.0

PKS_AT (1114..1412): mmal

ATSignature: Methylmalonyl-CoA

Top 3 matches:: Methylmalonyl-CoA: 95.8%; Methoxymalonyl-CoA: 87.5%; Ethylmalonyl-CoA: 83.3%

minowa: Methylmalonyl-CoA

Prediction, score:

Methylmalonyl-CoA: 201.9
Ethylmalonyl-CoA: 191.7
Methoxymalonyl-CoA: 168.9
2-Methylbutyryl-CoA: 147.7
Propionyl-CoA: 120.3
trans-1,2-CPDA: 116.4
Malonyl-CoA: 99.1
CHC-CoA: 96.4
Isobutyryl-CoA: 79.8
Benzoyl-CoA: 63.1
Acetyl-CoA: 49.9
3-Methylbutyryl-CoA: 34.4
fatty_acid: 33.9
inactive: 24.9

PKS_AT (2675..2977): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 83.3%; inactive: 66.7%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 136.3
inactive: 54.0
Methoxymalonyl-CoA: 44.9
Methylmalonyl-CoA: 33.7
Propionyl-CoA: 22.8
Acetyl-CoA: 17.2
Ethylmalonyl-CoA: 16.0
2-Methylbutyryl-CoA: 10.0
Isobutyryl-CoA: 5.2
CHC-CoA: 2.7
trans-1,2-CPDA: 0.0
fatty_acid: 0.0
Benzoyl-CoA: 0.0
3-Methylbutyryl-CoA: 0.0