BGC0000099 - 1 region(s) - antiSMASH results

Identified secondary metabolite regions using strictness 'relaxed'

BGC0000099 (Talaromyces marneffei (anamorph: Penicillium marneffei))

Region	Type	From	To	Most similar known cluster		Similarity
Region 1	T1PKS	1	8,104

BGC0000099 - Region 1 - T1PKS

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Location: 1 - 8,104 nt. (total: 8,104 nt) Show pHMM detection rules used

Region on contig edge.

T1PKS: cds(PKS_AT and (PKS_KS or ene_KS or mod_KS or hyb_KS or itr_KS or tra_KS))

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core biosynthetic genes

additional biosynthetic genes

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Gene details

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MIBiG

NRPS/PKS domains

MIBiG comparison

KnownClusterBlast

NRPS/PKS modules

External annotation

Name		MIBiG
Version		3.0

Type		Subregion
Location		1 - 8,105
Label		BGC0000099

Detailed domain annotation

Selected features only

Show module domains

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000099.1	1.00	Polyketide	monascorubrin	Talaromyces marneffei
BGC0000027.1	0.26	Polyketide	ankaflavin, monascin, rubropunctatine, monascorubrin	Monascus pilosus
BGC0000013.1	0.26	Polyketide	alternariol	Aspergillus nidulans FGSC A4
BGC0001338.1	0.23	Polyketide	citrinin	Monascus ruber
BGC0001976.1	0.21	Terpene	eupenifeldin	Phoma sp.
BGC0001977.1	0.21	Other	eupenifeldin	Phoma sp.
BGC0000154.1	0.21	Polyketide	stipitatic acid	Talaromyces stipitatus ATCC 10500
BGC0001144.1	0.21	Polyketide	neosartoricin B	Trichophyton tonsurans CBS 112818
BGC0001404.1	0.21	Polyketide	sorbicillin	Penicillium rubens Wisconsin 54-1255
BGC0001827.1	0.20	Polyketide	xenovulene A	Sarocladium sp. 'schorii'

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000099.1	1.00	Polyketide	monascorubrin	Talaromyces marneffei
BGC0000027.1	0.60	Polyketide	ankaflavin, monascin, rubropunctatine, monascorubrin	Monascus pilosus
BGC0000013.1	0.59	Polyketide	alternariol	Aspergillus nidulans FGSC A4
BGC0001338.1	0.56	Polyketide	citrinin	Monascus ruber
BGC0001976.1	0.54	Terpene	eupenifeldin	Phoma sp.
BGC0001977.1	0.54	Other	eupenifeldin	Phoma sp.
BGC0000154.1	0.53	Polyketide	stipitatic acid	Talaromyces stipitatus ATCC 10500
BGC0001144.1	0.53	Polyketide	neosartoricin B	Trichophyton tonsurans CBS 112818
BGC0001404.1	0.53	Polyketide	sorbicillin	Penicillium rubens Wisconsin 54-1255
BGC0001827.1	0.52	Polyketide	xenovulene A	Sarocladium sp. 'schorii'

Similar known gene clusters

No matches found.

Module view

Legend

NRPS/PKS products

NRPS/PKS monomers

Predicted core structure(s)

For candidate cluster 1, location 0 - 8104:

Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:: (pk)

Direct lookup in NORINE database: strict or relaxed

Link to NORINE database query form

NRPS/PKS monomer predictions

ADH01663.1

PKS_AT (899..1191): pk

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 66.7%; Ethylmalonyl-CoA: 54.2%; Methylmalonyl-CoA: 54.2%

minowa: Methoxymalonyl-CoA

Prediction, score:

Methoxymalonyl-CoA: 60.2
Methylmalonyl-CoA: 56.3
Malonyl-CoA: 52.8
inactive: 51.9
Propionyl-CoA: 33.9
Ethylmalonyl-CoA: 32.4
CHC-CoA: 30.1
2-Methylbutyryl-CoA: 25.3
trans-1,2-CPDA: 21.4
fatty_acid: 20.0
Acetyl-CoA: 12.3
3-Methylbutyryl-CoA: 10.8
Benzoyl-CoA: 10.6
Isobutyryl-CoA: 9.3