BGC0000114 - 1 region(s) - antiSMASH results

Identified secondary metabolite regions using strictness 'relaxed'

BGC0000114 (Streptomyces violaceusniger)

Region	Type	From	To	Similarity Confidence	Most similar known cluster
Region 1	T1PKS	1	95,700	High	nigericin	PKS:Type I

BGC0000114 - Region 1 - T1PKS

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Location: 1 - 95,700 nt. (total: 95,700 nt) Show pHMM detection rules used

Region on contig edge.

T1PKS: cds(PKS_AT and (PKS_KS or ene_KS or mod_KS or hyb_KS or itr_KS or tra_KS))

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core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

TTA codons

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Gene details

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Gene overview

MIBiG

Tailoring

MIBiG comparison

KnownClusterBlast

NRPS/PKS modules

NRPS/PKS domains

Gene/CDS overview

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Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

External annotation

Name		MIBiG
Version		4.0alpha

Type		Subregion
Location		1 - 95,701
Label		BGC0000114

Tailoring functions

Oxidoreductases: oxygenase

ABC84463.1: cytochrome P450

smcogs: SMCOG1007: cytochrome P450

ABC84466.1: monooxygenase FAD-binding

smcogs: SMCOG1246: monooxygenase FAD-binding

Transferases: acylase methyltransferase

ABC84455.1: methyltransferase

smcogs: SMCOG1089: methyltransferase

ABC84461.1: malonyl CoA-acyl carrier protein transacylase

smcogs: SMCOG1021: malonyl CoA-acyl carrier protein transacylase

ABC84470.1: malonyl CoA-acyl carrier protein transacylase

smcogs: SMCOG1021: malonyl CoA-acyl carrier protein transacylase

Hydrolases: dehalogenase

ABC84462.1: haloalkane dehalogenase

smcogs: SMCOG1262: haloalkane dehalogenase

Ligases: synthase

ABC84456.1: Beta-ketoacyl synthase

smcogs: SMCOG1022: Beta-ketoacyl synthase

ABC84457.1: Beta-ketoacyl synthase

smcogs: SMCOG1022: Beta-ketoacyl synthase

ABC84458.1: Beta-ketoacyl synthase

smcogs: SMCOG1022: Beta-ketoacyl synthase

ABC84459.1: Beta-ketoacyl synthase

smcogs: SMCOG1022: Beta-ketoacyl synthase

ABC84460.1: Beta-ketoacyl synthase

smcogs: SMCOG1022: Beta-ketoacyl synthase

ABC84465.1: Beta-ketoacyl synthase

smcogs: SMCOG1022: Beta-ketoacyl synthase

ABC84469.1: Beta-ketoacyl synthase

smcogs: SMCOG1093: Beta-ketoacyl synthase

ABC84471.1: Beta-ketoacyl synthase

smcogs: SMCOG1022: Beta-ketoacyl synthase

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000114.5	1.00	PKS	nigericin	Streptomyces violaceusniger
BGC0001276.3	0.77	PKS	6-methylsalicyclic acid	Aspergillus terreus
BGC0002038.2	0.74	PKS	nigericin	Streptomyces sp. DASNCL29
BGC0002191.2	0.67	PKS	prolipyrone B, gibepyrone D	Fusarium graminearum PH-1
BGC0001273.3	0.67	PKS	asperlactone	Aspergillus ochraceus
BGC0001275.3	0.67	PKS	6-methylsalicyclic acid	Glarea lozoyensis
BGC0001244.3	0.67	PKS	(-)-Mellein	Parastagonospora nodorum
BGC0001160.5	0.66	PKS	1-nonadecene, (14Z)-1,14-nonadecadiene	Synechococcus sp. PCC 7002
BGC0001284.4	0.66	PKS	alternariol	Parastagonospora nodorum SN15
BGC0001164.3	0.66	PKS	1-heptadecene	Cyanothece sp. PCC 7822

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000114.5	1.00	PKS	nigericin	Streptomyces violaceusniger
BGC0001276.3	0.77	PKS	6-methylsalicyclic acid	Aspergillus terreus
BGC0002038.2	0.74	PKS	nigericin	Streptomyces sp. DASNCL29
BGC0002191.2	0.67	PKS	prolipyrone B, gibepyrone D	Fusarium graminearum PH-1
BGC0001273.3	0.67	PKS	asperlactone	Aspergillus ochraceus
BGC0001275.3	0.67	PKS	6-methylsalicyclic acid	Glarea lozoyensis
BGC0001244.3	0.67	PKS	(-)-Mellein	Parastagonospora nodorum
BGC0001160.5	0.66	PKS	1-nonadecene, (14Z)-1,14-nonadecadiene	Synechococcus sp. PCC 7002
BGC0001284.4	0.66	PKS	alternariol	Parastagonospora nodorum SN15
BGC0001164.3	0.66	PKS	1-heptadecene	Cyanothece sp. PCC 7822

Similar known clusters from MIBiG 4.0

Module view

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Detailed domain annotation

Selected features only

Show module domains

NRPS/PKS products

NRPS/PKS substrates

Predicted core structure(s)

For candidate cluster 1, location 0 - 95700:

Rough prediction of core scaffold based on assumed PKS linker matching; tailoring reactions not taken into account

Polymer prediction:: (mal - Me-mal) + (Me-redmal) + (ccmal - Me-redmal) + (Me-ccmal - redmal) + (Me-ccmal - Me-redmal) + (Me-ohmal) + (ohmal - ohmal - ohmal) + (Me-redmal) + (Me-ccmal)
Non-colinear ordering:: ABC84456.1 + ABC84457.1 + ABC84458.1 + ABC84459.1 + ABC84460.1 + ABC84461.1 + ABC84471.1 + ABC84470.1 + ABC84469.1

Direct lookup in NORINE database: strict or relaxed

Link to NORINE database query form

NRPS/PKS substrate predictions

ABC84456.1: mal - mmal

PKS_AT (541..848): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 100.0%; inactive: 83.3%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 207.5
inactive: 92.1
Methoxymalonyl-CoA: 72.7
Methylmalonyl-CoA: 63.0
Isobutyryl-CoA: 42.1
Ethylmalonyl-CoA: 28.9
Acetyl-CoA: 28.7
Propionyl-CoA: 27.0
Benzoyl-CoA: 26.8
CHC-CoA: 17.7
fatty_acid: 13.3
3-Methylbutyryl-CoA: 13.2
2-Methylbutyryl-CoA: 9.8
trans-1,2-CPDA: -0.3

PKS_AT (1577..1880): mmal

ATSignature: Methylmalonyl-CoA

Top 3 matches:: Methylmalonyl-CoA: 100.0%; Methoxymalonyl-CoA: 87.5%; Ethylmalonyl-CoA: 83.3%

minowa: Methylmalonyl-CoA

Prediction, score:

Methylmalonyl-CoA: 197.9
Ethylmalonyl-CoA: 191.3
Methoxymalonyl-CoA: 167.0
trans-1,2-CPDA: 129.9
2-Methylbutyryl-CoA: 126.0
Propionyl-CoA: 111.3
Malonyl-CoA: 94.3
CHC-CoA: 92.5
Isobutyryl-CoA: 70.3
fatty_acid: 44.8
Benzoyl-CoA: 44.8
Acetyl-CoA: 31.2
3-Methylbutyryl-CoA: 24.8
inactive: 16.9

ABC84457.1: mmal

PKS_AT (566..869): mmal

ATSignature: Methylmalonyl-CoA

Top 3 matches:: Methylmalonyl-CoA: 100.0%; Methoxymalonyl-CoA: 95.8%; Ethylmalonyl-CoA: 91.7%

minowa: Methylmalonyl-CoA

Prediction, score:

Methylmalonyl-CoA: 210.7
Ethylmalonyl-CoA: 206.8
Methoxymalonyl-CoA: 174.4
trans-1,2-CPDA: 135.7
2-Methylbutyryl-CoA: 131.2
Propionyl-CoA: 111.4
Malonyl-CoA: 110.8
CHC-CoA: 108.4
Isobutyryl-CoA: 73.3
Benzoyl-CoA: 68.8
fatty_acid: 48.0
Acetyl-CoA: 46.1
3-Methylbutyryl-CoA: 36.4
inactive: 20.9

ABC84458.1: mal - mmal

PKS_AT (596..895): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 100.0%; inactive: 83.3%; Propionyl-CoA: 54.2%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 225.2
inactive: 119.9
Methoxymalonyl-CoA: 55.2
Methylmalonyl-CoA: 44.0
Propionyl-CoA: 29.1
Isobutyryl-CoA: 27.1
Acetyl-CoA: 22.8
Benzoyl-CoA: 16.3
Ethylmalonyl-CoA: 10.5
2-Methylbutyryl-CoA: 8.5
trans-1,2-CPDA: 0.0
fatty_acid: 0.0
CHC-CoA: 0.0
3-Methylbutyryl-CoA: 0.0

PKS_AT (2398..2701): mmal

ATSignature: Methylmalonyl-CoA

Top 3 matches:: Methylmalonyl-CoA: 100.0%; Methoxymalonyl-CoA: 95.8%; Ethylmalonyl-CoA: 91.7%

minowa: Methylmalonyl-CoA

Prediction, score:

Methylmalonyl-CoA: 213.4
Ethylmalonyl-CoA: 206.9
Methoxymalonyl-CoA: 177.5
trans-1,2-CPDA: 149.4
2-Methylbutyryl-CoA: 140.3
Propionyl-CoA: 121.6
Malonyl-CoA: 109.7
CHC-CoA: 97.6
Isobutyryl-CoA: 70.9
Benzoyl-CoA: 58.5
Acetyl-CoA: 56.3
fatty_acid: 53.3
3-Methylbutyryl-CoA: 32.4
inactive: 24.8

ABC84459.1: mmal - mal

PKS_AT (565..865): mmal

ATSignature: Methylmalonyl-CoA

Top 3 matches:: Methylmalonyl-CoA: 100.0%; Methoxymalonyl-CoA: 95.8%; Ethylmalonyl-CoA: 91.7%

minowa: Methylmalonyl-CoA

Prediction, score:

Methylmalonyl-CoA: 211.2
Ethylmalonyl-CoA: 208.1
Methoxymalonyl-CoA: 175.4
trans-1,2-CPDA: 138.3
2-Methylbutyryl-CoA: 133.7
Propionyl-CoA: 115.1
CHC-CoA: 114.0
Malonyl-CoA: 108.2
Isobutyryl-CoA: 66.7
Benzoyl-CoA: 65.0
Acetyl-CoA: 51.0
fatty_acid: 50.3
3-Methylbutyryl-CoA: 37.5
inactive: 27.0

PKS_AT (2364..2656): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 100.0%; inactive: 75.0%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 179.2
inactive: 95.5
Methylmalonyl-CoA: 63.2
Methoxymalonyl-CoA: 61.2
fatty_acid: 37.2
Isobutyryl-CoA: 36.3
Propionyl-CoA: 34.5
2-Methylbutyryl-CoA: 26.8
Acetyl-CoA: 22.9
Ethylmalonyl-CoA: 21.0
trans-1,2-CPDA: 14.3
CHC-CoA: 14.2
Benzoyl-CoA: 7.9
3-Methylbutyryl-CoA: 0.0

ABC84460.1: mmal - mmal

PKS_AT (565..865): mmal

ATSignature: Methylmalonyl-CoA

Top 3 matches:: Methylmalonyl-CoA: 100.0%; Methoxymalonyl-CoA: 95.8%; Ethylmalonyl-CoA: 91.7%

minowa: Methylmalonyl-CoA

Prediction, score:

Methylmalonyl-CoA: 211.2
Ethylmalonyl-CoA: 203.6
Methoxymalonyl-CoA: 174.4
trans-1,2-CPDA: 141.4
2-Methylbutyryl-CoA: 133.5
Propionyl-CoA: 108.5
Malonyl-CoA: 106.5
CHC-CoA: 102.7
Isobutyryl-CoA: 72.8
Benzoyl-CoA: 68.6
fatty_acid: 43.0
3-Methylbutyryl-CoA: 41.7
Acetyl-CoA: 40.8
inactive: 21.9

PKS_AT (2374..2677): mmal

ATSignature: Methylmalonyl-CoA

Top 3 matches:: Methylmalonyl-CoA: 100.0%; Methoxymalonyl-CoA: 95.8%; Ethylmalonyl-CoA: 91.7%

minowa: Methylmalonyl-CoA

Prediction, score:

Methylmalonyl-CoA: 210.9
Ethylmalonyl-CoA: 206.5
Methoxymalonyl-CoA: 173.7
trans-1,2-CPDA: 145.1
2-Methylbutyryl-CoA: 127.4
Propionyl-CoA: 110.3
Malonyl-CoA: 108.4
CHC-CoA: 94.3
Isobutyryl-CoA: 70.2
Benzoyl-CoA: 57.4
Acetyl-CoA: 42.6
fatty_acid: 40.0
3-Methylbutyryl-CoA: 23.9
inactive: 21.9

ABC84461.1: mmal

PKS_AT (588..888): mmal

ATSignature: Methylmalonyl-CoA

Top 3 matches:: Methylmalonyl-CoA: 100.0%; Methoxymalonyl-CoA: 95.8%; Ethylmalonyl-CoA: 91.7%

minowa: Methylmalonyl-CoA

Prediction, score:

Methylmalonyl-CoA: 205.5
Ethylmalonyl-CoA: 203.6
Methoxymalonyl-CoA: 174.7
2-Methylbutyryl-CoA: 127.4
trans-1,2-CPDA: 123.2
Propionyl-CoA: 106.5
Malonyl-CoA: 103.0
CHC-CoA: 90.4
Isobutyryl-CoA: 64.7
Benzoyl-CoA: 46.8
Acetyl-CoA: 40.1
fatty_acid: 37.5
3-Methylbutyryl-CoA: 22.4
inactive: 21.3

ABC84469.1: mmal

PKS_AT (576..876): mmal

ATSignature: Methylmalonyl-CoA

Top 3 matches:: Methylmalonyl-CoA: 100.0%; Methoxymalonyl-CoA: 95.8%; Ethylmalonyl-CoA: 91.7%

minowa: Methylmalonyl-CoA

Prediction, score:

Methylmalonyl-CoA: 205.7
Ethylmalonyl-CoA: 196.7
Methoxymalonyl-CoA: 170.3
2-Methylbutyryl-CoA: 149.3
trans-1,2-CPDA: 127.3
Propionyl-CoA: 122.1
Malonyl-CoA: 97.7
CHC-CoA: 97.0
Isobutyryl-CoA: 70.9
fatty_acid: 51.6
Acetyl-CoA: 47.4
Benzoyl-CoA: 46.3
3-Methylbutyryl-CoA: 40.5
inactive: 17.1

ABC84470.1: mmal

PKS_AT (578..878): mmal

ATSignature: Methylmalonyl-CoA

Top 3 matches:: Methylmalonyl-CoA: 100.0%; Methoxymalonyl-CoA: 95.8%; Ethylmalonyl-CoA: 91.7%

minowa: Methylmalonyl-CoA

Prediction, score:

Methylmalonyl-CoA: 204.4
Ethylmalonyl-CoA: 192.1
Methoxymalonyl-CoA: 170.7
2-Methylbutyryl-CoA: 146.8
trans-1,2-CPDA: 123.3
Propionyl-CoA: 120.8
Malonyl-CoA: 102.2
CHC-CoA: 89.4
Isobutyryl-CoA: 71.1
fatty_acid: 52.5
Benzoyl-CoA: 48.7
Acetyl-CoA: 43.6
3-Methylbutyryl-CoA: 36.6
inactive: 17.2

ABC84471.1: mal - mal - mal

PKS_AT (577..876): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 100.0%; inactive: 75.0%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 167.2
inactive: 76.0
Methoxymalonyl-CoA: 62.5
Methylmalonyl-CoA: 53.7
fatty_acid: 31.2
Propionyl-CoA: 28.4
Isobutyryl-CoA: 23.7
2-Methylbutyryl-CoA: 21.1
Ethylmalonyl-CoA: 21.0
Acetyl-CoA: 20.9
trans-1,2-CPDA: 11.3
Benzoyl-CoA: 9.2
CHC-CoA: 0.0
3-Methylbutyryl-CoA: 0.0

PKS_AT (2145..2448): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 100.0%; inactive: 75.0%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 168.4
inactive: 72.2
Methoxymalonyl-CoA: 62.8
Methylmalonyl-CoA: 51.6
Propionyl-CoA: 31.7
fatty_acid: 31.3
Isobutyryl-CoA: 22.2
Ethylmalonyl-CoA: 17.2
2-Methylbutyryl-CoA: 15.9
Acetyl-CoA: 15.1
trans-1,2-CPDA: 9.6
Benzoyl-CoA: 9.2
CHC-CoA: 0.0
3-Methylbutyryl-CoA: 0.0

PKS_AT (3696..3989): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 100.0%; inactive: 75.0%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 164.3
inactive: 71.5
Methoxymalonyl-CoA: 60.7
Methylmalonyl-CoA: 50.9
fatty_acid: 31.8
Propionyl-CoA: 29.6
Ethylmalonyl-CoA: 20.6
Isobutyryl-CoA: 18.8
Acetyl-CoA: 17.6
2-Methylbutyryl-CoA: 14.2
trans-1,2-CPDA: 9.2
Benzoyl-CoA: 9.1
CHC-CoA: 0.0
3-Methylbutyryl-CoA: 0.0

Link to PARAS substrate predictor