BGC0000122 - 1 region(s) - antiSMASH results

Identified secondary metabolite regions using strictness 'relaxed'

BGC0000122 (Nannocystis pusilla)

Region	Type	From	To	Most similar known cluster		Similarity
Region 1	NRPS-like,T1PKS	1	36,839	ECO-02301	Polyketide	7%

BGC0000122 - Region 1 - NRPS-like,T1PKS

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Location: 1 - 36,839 nt. (total: 36,839 nt) Show pHMM detection rules used

Region on contig edge.

NRPS-like: cds((PP-binding or NAD_binding_4) and (AMP-binding or A-OX))
T1PKS: cds(PKS_AT and (PKS_KS or ene_KS or mod_KS or hyb_KS or itr_KS or tra_KS))

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core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

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resistance

TTA codons

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Gene details

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MIBiG

NRPS/PKS domains

MIBiG comparison

KnownClusterBlast

NRPS/PKS modules

External annotation

Name		MIBiG
Version		3.0

Type		Subregion
Location		1 - 36,840
Label		BGC0000122

Detailed domain annotation

Selected features only

Show module domains

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000122.1	1.34	Polyketide	phenylnannolone A, phenylnannolone B, phenylnannolone C	Nannocystis pusilla
BGC0001544.1	0.29	NRP, Polyketide	chlorflavonin	Aspergillus campestris IBT 28561
BGC0002081.1	0.27	Polyketide	streptoketide A, streptoketide B, streptoketide C, S2502, S2507, UWM5	Streptomyces sp. Tue6314
BGC0000353.1	0.26	NRP	tacrolimus	Streptomyces sp. MA6548
BGC0001235.1	0.25	NRP, Polyketide	antalid	Polyangium spumosum
BGC0001991.1	0.24	Polyketide	toblerol A, toblerol B, toblerol C, toblerol D, toblerol E, toblerol F, toblerol G, toblerol H	Methylorubrum extorquens AM1
BGC0000180.1	0.23	Polyketide	legioliulin	Legionella parisiensis
BGC0000041.1	0.23	Polyketide	oronofacic acid	Pseudomonas syringae
BGC0000143.1	0.22	Polyketide	salinomycin	Streptomyces albus
BGC0000235.1	0.22	Polyketide	kiamycin	Streptomyces sp. W007

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000122.1	0.87	Polyketide	phenylnannolone A, phenylnannolone B, phenylnannolone C	Nannocystis pusilla
BGC0001544.1	0.44	NRP, Polyketide	chlorflavonin	Aspergillus campestris IBT 28561
BGC0002081.1	0.42	Polyketide	streptoketide A, streptoketide B, streptoketide C, S2502, S2507, UWM5	Streptomyces sp. Tue6314
BGC0000353.1	0.41	NRP	tacrolimus	Streptomyces sp. MA6548
BGC0001235.1	0.41	NRP, Polyketide	antalid	Polyangium spumosum
BGC0001991.1	0.40	Polyketide	toblerol A, toblerol B, toblerol C, toblerol D, toblerol E, toblerol F, toblerol G, toblerol H	Methylorubrum extorquens AM1
BGC0000180.1	0.39	Polyketide	legioliulin	Legionella parisiensis
BGC0000041.1	0.39	Polyketide	oronofacic acid	Pseudomonas syringae
BGC0000143.1	0.38	Polyketide	salinomycin	Streptomyces albus
BGC0000235.1	0.38	Polyketide	kiamycin	Streptomyces sp. W007

Similar known gene clusters

Module view

Legend

NRPS/PKS products

NRPS/PKS monomers

Predicted core structure(s)

For candidate cluster 1, location 0 - 36839:

Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:: (pk - ccmal - mal - ccmal)

Direct lookup in NORINE database: strict or relaxed

Link to NORINE database query form

NRPS/PKS monomer predictions

phn2

CAL_domain (46..505): pk

minowa: NH2

Prediction, score:

NH2: 166.0
AHBA: 9.7
Acetyl-CoA: 2.4
fatty_acid: 0.9
shikimic_acid: 0.0

PKS_AT (1262..1559): pk

ATSignature: Methoxymalonyl-CoA

Top 3 matches:: Methoxymalonyl-CoA: 83.3%; Ethylmalonyl-CoA: 79.2%; Methylmalonyl-CoA: 79.2%

minowa: Methylmalonyl-CoA

Prediction, score:

Methylmalonyl-CoA: 177.4
Ethylmalonyl-CoA: 175.8
Methoxymalonyl-CoA: 150.3
2-Methylbutyryl-CoA: 103.7
trans-1,2-CPDA: 103.1
Propionyl-CoA: 100.9
CHC-CoA: 90.4
Isobutyryl-CoA: 75.1
Malonyl-CoA: 74.9
Benzoyl-CoA: 69.6
Acetyl-CoA: 53.1
3-Methylbutyryl-CoA: 33.8
inactive: 27.0
fatty_acid: 26.3

PKS_AT (3024..3321): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 87.5%; inactive: 79.2%; Methylmalonyl-CoA: 54.2%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 199.9
inactive: 120.7
Methoxymalonyl-CoA: 75.9
Methylmalonyl-CoA: 63.7
Propionyl-CoA: 41.8
Isobutyryl-CoA: 26.7
Ethylmalonyl-CoA: 25.5
Acetyl-CoA: 23.3
2-Methylbutyryl-CoA: 20.5
Benzoyl-CoA: 13.7
fatty_acid: 11.4
trans-1,2-CPDA: 9.5
3-Methylbutyryl-CoA: 8.5
CHC-CoA: 6.3

PKS_AT (4815..5112): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 87.5%; inactive: 79.2%; Methylmalonyl-CoA: 54.2%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 200.0
inactive: 120.4
Methoxymalonyl-CoA: 74.9
Methylmalonyl-CoA: 66.3
Propionyl-CoA: 43.3
Isobutyryl-CoA: 28.2
Ethylmalonyl-CoA: 24.9
Acetyl-CoA: 23.0
2-Methylbutyryl-CoA: 22.0
Benzoyl-CoA: 14.0
trans-1,2-CPDA: 12.7
fatty_acid: 11.2
3-Methylbutyryl-CoA: 9.3
CHC-CoA: 7.2

PKS_AT (5835..6135): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 87.5%; inactive: 75.0%; Methylmalonyl-CoA: 54.2%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 215.5
inactive: 110.6
Methoxymalonyl-CoA: 84.0
Methylmalonyl-CoA: 76.0
Isobutyryl-CoA: 54.8
Ethylmalonyl-CoA: 45.0
Propionyl-CoA: 38.5
Benzoyl-CoA: 30.1
Acetyl-CoA: 29.7
2-Methylbutyryl-CoA: 21.7
CHC-CoA: 17.0
trans-1,2-CPDA: 14.4
fatty_acid: 12.9
3-Methylbutyryl-CoA: 7.8