BGC0000166 - 1 region(s) - antiSMASH results

Identified secondary metabolite regions using strictness 'relaxed'

BGC0000166 (Streptomyces fradiae)

Region	Type	From	To	Most similar known cluster		Similarity
Region 1	T1PKS	1	43,280	chalcomycin A	Polyketide	14%

BGC0000166 - Region 1 - T1PKS

Download region GenBank file

Download region SVG

Location: 1 - 43,280 nt. (total: 43,280 nt) Show pHMM detection rules used

Region on contig edge.

T1PKS: cds(PKS_AT and (PKS_KS or ene_KS or mod_KS or hyb_KS or itr_KS or tra_KS))

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

TTA codons

reset view

zoom to selection

Gene details

Select a gene to view the details available for it

MIBiG

NRPS/PKS domains

MIBiG comparison

KnownClusterBlast

NRPS/PKS modules

External annotation

Name		MIBiG
Version		3.0

Type		Subregion
Location		1 - 43,281
Label		BGC0000166

Detailed domain annotation

Selected features only

Show module domains

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000018.1	0.48	Polyketide	angolamycin	Streptomyces eurythermus
BGC0000041.1	0.36	Polyketide	oronofacic acid	Pseudomonas syringae
BGC0001812.1	0.36	Polyketide	tylactone	Micromonospora chalcea subsp. izumensis
BGC0002086.1	0.34	Polyketide	rosamicin	Micromonospora carbonacea
BGC0000113.1	0.34	Polyketide	niddamycin	Streptomyces caelestis
BGC0000096.1	0.33	Polyketide	midecamycin	Streptomyces mycarofaciens
BGC0001909.1	0.32	Polyketide	strobilurin	Strobilurus tenacellus
BGC0000067.1	0.32	Polyketide	geldanamycin	Streptomyces hygroscopicus subsp. duamyceticus
BGC0001830.1	0.31	Polyketide	rosamicin, salinipyrone A, pacificanone A	Salinispora pacifica
BGC0000057.1	0.29	Polyketide	F9775A, F9775B, orsellinic acid	Aspergillus nidulans FGSC A4

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000018.1	0.78	Polyketide	angolamycin	Streptomyces eurythermus
BGC0000041.1	0.69	Polyketide	oronofacic acid	Pseudomonas syringae
BGC0001812.1	0.69	Polyketide	tylactone	Micromonospora chalcea subsp. izumensis
BGC0002086.1	0.67	Polyketide	rosamicin	Micromonospora carbonacea
BGC0000113.1	0.67	Polyketide	niddamycin	Streptomyces caelestis
BGC0000096.1	0.66	Polyketide	midecamycin	Streptomyces mycarofaciens
BGC0001909.1	0.65	Polyketide	strobilurin	Strobilurus tenacellus
BGC0000067.1	0.65	Polyketide	geldanamycin	Streptomyces hygroscopicus subsp. duamyceticus
BGC0001830.1	0.65	Polyketide	rosamicin, salinipyrone A, pacificanone A	Salinispora pacifica
BGC0000057.1	0.63	Polyketide	F9775A, F9775B, orsellinic acid	Aspergillus nidulans FGSC A4

Similar known gene clusters

Module view

Legend

NRPS/PKS products

NRPS/PKS monomers

Predicted core structure(s)

For candidate cluster 1, location 0 - 43280:

Rough prediction of core scaffold based on assumed PKS linker matching; tailoring reactions not taken into account

Polymer prediction:: (Me-mal - Me-ccmal - Me-ccmal) + (Me-ohmal) + (Me-ohmal - redemal) + (ccmal) + (ohmal)
Non-colinear ordering:: tylG + tylG_rename3 + tylG_rename2 + tylG_rename1 + tylG_rename4

Direct lookup in NORINE database: strict or relaxed

Link to NORINE database query form

NRPS/PKS monomer predictions

tylG

PKS_AT (588..881): mmal

ATSignature: Methylmalonyl-CoA

Top 3 matches:: Methylmalonyl-CoA: 100.0%; Methoxymalonyl-CoA: 95.8%; Ethylmalonyl-CoA: 91.7%

minowa: Methylmalonyl-CoA

Prediction, score:

Methylmalonyl-CoA: 196.3
Ethylmalonyl-CoA: 174.6
Methoxymalonyl-CoA: 156.2
2-Methylbutyryl-CoA: 107.2
trans-1,2-CPDA: 96.4
Propionyl-CoA: 91.9
CHC-CoA: 91.7
Malonyl-CoA: 88.1
Isobutyryl-CoA: 70.6
3-Methylbutyryl-CoA: 48.3
Benzoyl-CoA: 41.9
Acetyl-CoA: 41.5
inactive: 26.9
fatty_acid: 25.0

PKS_AT (1608..1901): mmal

ATSignature: Methylmalonyl-CoA

Top 3 matches:: Methylmalonyl-CoA: 100.0%; Methoxymalonyl-CoA: 95.8%; Ethylmalonyl-CoA: 91.7%

minowa: Methylmalonyl-CoA

Prediction, score:

Methylmalonyl-CoA: 196.3
Ethylmalonyl-CoA: 174.6
Methoxymalonyl-CoA: 156.2
2-Methylbutyryl-CoA: 107.2
trans-1,2-CPDA: 96.4
Propionyl-CoA: 91.9
CHC-CoA: 91.7
Malonyl-CoA: 88.1
Isobutyryl-CoA: 70.6
3-Methylbutyryl-CoA: 48.3
Benzoyl-CoA: 41.9
Acetyl-CoA: 41.5
inactive: 26.9
fatty_acid: 25.0

PKS_AT (3151..3444): mmal

ATSignature: Methylmalonyl-CoA

Top 3 matches:: Methylmalonyl-CoA: 100.0%; Methoxymalonyl-CoA: 95.8%; Ethylmalonyl-CoA: 91.7%

minowa: Methylmalonyl-CoA

Prediction, score:

Methylmalonyl-CoA: 196.3
Ethylmalonyl-CoA: 174.6
Methoxymalonyl-CoA: 156.2
2-Methylbutyryl-CoA: 107.2
trans-1,2-CPDA: 96.4
Propionyl-CoA: 91.9
CHC-CoA: 91.7
Malonyl-CoA: 88.1
Isobutyryl-CoA: 70.6
3-Methylbutyryl-CoA: 48.3
Benzoyl-CoA: 41.9
Acetyl-CoA: 41.5
inactive: 26.9
fatty_acid: 25.0

tylG_rename1

PKS_AT (569..860): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 100.0%; inactive: 70.8%; Methylmalonyl-CoA: 62.5%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 217.5
inactive: 96.2
Methoxymalonyl-CoA: 90.6
Methylmalonyl-CoA: 85.4
Propionyl-CoA: 54.1
Isobutyryl-CoA: 53.6
Ethylmalonyl-CoA: 47.3
2-Methylbutyryl-CoA: 37.2
trans-1,2-CPDA: 26.9
fatty_acid: 24.5
Acetyl-CoA: 22.8
CHC-CoA: 22.7
Benzoyl-CoA: 22.2
3-Methylbutyryl-CoA: 14.3

tylG_rename2

PKS_AT (590..883): mmal

ATSignature: Methylmalonyl-CoA

Top 3 matches:: Methylmalonyl-CoA: 100.0%; Methoxymalonyl-CoA: 95.8%; Ethylmalonyl-CoA: 91.7%

minowa: Methylmalonyl-CoA

Prediction, score:

Methylmalonyl-CoA: 196.3
Ethylmalonyl-CoA: 174.6
Methoxymalonyl-CoA: 156.2
2-Methylbutyryl-CoA: 107.2
trans-1,2-CPDA: 96.4
Propionyl-CoA: 91.9
CHC-CoA: 91.7
Malonyl-CoA: 88.1
Isobutyryl-CoA: 70.6
3-Methylbutyryl-CoA: 48.3
Benzoyl-CoA: 41.9
Acetyl-CoA: 41.5
inactive: 26.9
fatty_acid: 25.0

PKS_AT (2097..2395): emal

ATSignature: Ethylmalonyl-CoA

Top 3 matches:: Ethylmalonyl-CoA: 100.0%; Methoxymalonyl-CoA: 91.7%; Methylmalonyl-CoA: 91.7%

minowa: Ethylmalonyl-CoA

Prediction, score:

Ethylmalonyl-CoA: 245.5
Methylmalonyl-CoA: 200.5
Methoxymalonyl-CoA: 179.9
trans-1,2-CPDA: 152.7
2-Methylbutyryl-CoA: 146.5
Propionyl-CoA: 120.9
CHC-CoA: 95.5
Malonyl-CoA: 84.0
Isobutyryl-CoA: 77.9
Benzoyl-CoA: 75.3
Acetyl-CoA: 60.4
fatty_acid: 41.5
3-Methylbutyryl-CoA: 40.4
inactive: 21.9

tylG_rename3

PKS_AT (584..877): mmal

ATSignature: Methylmalonyl-CoA

Top 3 matches:: Methylmalonyl-CoA: 100.0%; Methoxymalonyl-CoA: 95.8%; Ethylmalonyl-CoA: 91.7%

minowa: Methylmalonyl-CoA

Prediction, score:

Methylmalonyl-CoA: 196.3
Ethylmalonyl-CoA: 174.6
Methoxymalonyl-CoA: 156.2
2-Methylbutyryl-CoA: 107.2
trans-1,2-CPDA: 96.4
Propionyl-CoA: 91.9
CHC-CoA: 91.7
Malonyl-CoA: 88.1
Isobutyryl-CoA: 70.6
3-Methylbutyryl-CoA: 48.3
Benzoyl-CoA: 41.9
Acetyl-CoA: 41.5
inactive: 26.9
fatty_acid: 25.0

tylG_rename4

PKS_AT (578..868): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 100.0%; inactive: 75.0%; Methylmalonyl-CoA: 58.3%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 203.0
inactive: 92.7
Methoxymalonyl-CoA: 71.2
Methylmalonyl-CoA: 64.4
Isobutyryl-CoA: 41.7
Propionyl-CoA: 35.2
Ethylmalonyl-CoA: 24.4
Acetyl-CoA: 21.3
2-Methylbutyryl-CoA: 15.0
Benzoyl-CoA: 13.2
CHC-CoA: 12.6
3-Methylbutyryl-CoA: 11.7
fatty_acid: 6.5
trans-1,2-CPDA: 0.1