BGC0000355 - 1 region(s) - antiSMASH results

Identified secondary metabolite regions using strictness 'relaxed'

BGC0000355 (Aspergillus fumigatus Af293)

Region	Type	From	To	Most similar known cluster		Similarity
Region 1	NRPS	1	24,812	tryptoquialanine	NRP	18%

BGC0000355 - Region 1 - NRPS

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Location: 1 - 24,812 nt. (total: 24,812 nt) Show pHMM detection rules used

Region on contig edge.

NRPS: cds(Condensation and (AMP-binding or A-OX))

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core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

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Gene details

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MIBiG

NRPS/PKS domains

MIBiG comparison

KnownClusterBlast

NRPS/PKS modules

External annotation

Name		MIBiG
Version		3.0

Type		Subregion
Location		1 - 24,813
Label		BGC0000355

Detailed domain annotation

Selected features only

Show module domains

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000355.1	1.00	NRP	fumiquinazoline A, fumiquinazoline C, fumiquinazoline D	Aspergillus fumigatus Af293
BGC0000900.1	0.33	Other	ferrichrome	Aspergillus oryzae
BGC0000375.1	0.32	NRP	indigoidine	Streptomyces chromofuscus
BGC0001249.1	0.32	NRP	dimethylcoprogen	Alternaria alternata
BGC0000427.1	0.32	NRP	shinorine, 4-deoxygadusol, mycosporine glycine	Trichormus variabilis ATCC 29413
BGC0000293.1	0.32	NRP	acetylaszonalenin	Aspergillus fischeri NRRL 181
BGC0001479.1	0.31	NRP	anabaenopeptin NZ857, nostamide A	Nostoc punctiforme PCC 73102
BGC0000348.1	0.30	NRP	ergovaline	Epichloe festucae var. lolii
BGC0000357.1	0.29	NRP	cyclo-(D-Phe-L-Phe-D-Val-L-Val), cyclo-(D-Tyr-L-Phe-D-Val-L-Val), cyclo-(D-Tyr-L-Trp-D-Val-L-Val), cyclo-(D-Phe-L-Trp-D-Val-L-Val), cyclo-(D-Phe-L-Phe-D-Val-L-Ile), cyclo-(D-Phe-L-Phe-D-Ile-L-Val), cyclo-(D-Tyr-L-Trp-D-Val-L-Ile), cyclo-(D-Tyr-L-Trp-D-Ile-L-Val), cyclo-(D-Tyr-L-Phe-D-Val-L-Ile), cyclo-(D-Tyr-L-Phe-D-Ile-L-Val)	Penicillium rubens Wisconsin 54-1255
BGC0001873.1	0.28	NRP	pyrrolizixenamide A	Xenorhabdus szentirmaii DSM 16338

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000355.1	1.00	NRP	fumiquinazoline A, fumiquinazoline C, fumiquinazoline D	Aspergillus fumigatus Af293
BGC0000900.1	0.66	Other	ferrichrome	Aspergillus oryzae
BGC0000375.1	0.65	NRP	indigoidine	Streptomyces chromofuscus
BGC0001249.1	0.65	NRP	dimethylcoprogen	Alternaria alternata
BGC0000427.1	0.65	NRP	shinorine, 4-deoxygadusol, mycosporine glycine	Trichormus variabilis ATCC 29413
BGC0000293.1	0.65	NRP	acetylaszonalenin	Aspergillus fischeri NRRL 181
BGC0001479.1	0.65	NRP	anabaenopeptin NZ857, nostamide A	Nostoc punctiforme PCC 73102
BGC0000348.1	0.63	NRP	ergovaline	Epichloe festucae var. lolii
BGC0000357.1	0.62	NRP	cyclo-(D-Phe-L-Phe-D-Val-L-Val), cyclo-(D-Tyr-L-Phe-D-Val-L-Val), cyclo-(D-Tyr-L-Trp-D-Val-L-Val), cyclo-(D-Phe-L-Trp-D-Val-L-Val), cyclo-(D-Phe-L-Phe-D-Val-L-Ile), cyclo-(D-Phe-L-Phe-D-Ile-L-Val), cyclo-(D-Tyr-L-Trp-D-Val-L-Ile), cyclo-(D-Tyr-L-Trp-D-Ile-L-Val), cyclo-(D-Tyr-L-Phe-D-Val-L-Ile), cyclo-(D-Tyr-L-Phe-D-Ile-L-Val)	Penicillium rubens Wisconsin 54-1255
BGC0001873.1	0.62	NRP	pyrrolizixenamide A	Xenorhabdus szentirmaii DSM 16338

Similar known gene clusters

Module view

Legend

NRPS/PKS products

NRPS/PKS monomers

Predicted core structure(s)

For candidate cluster 1, location 0 - 24812:

Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:: (ala) + (X - D-X - ala)

Direct lookup in NORINE database: strict or relaxed

Link to NORINE database query form

NRPS/PKS monomer predictions

AFUA_6G12050

Search NORINE for peptide: strict or relaxed

AMP-binding (110..505): ala

NRPSPredictor2: ala

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic
Large clusters prediction:: gly, ala, val, leu, ile, abu, iva
Small clusters prediction:: gly, ala
Single AA prediction:: ala

Stachelhaus prediction details:

Stachelhaus sequence:: dlfvlagcik
Nearest Stachelhaus code:: N, A
Stachelhaus code match:: 0% (weak)

AFUA_6G12080

Search NORINE for peptide: strict or relaxed

AMP-binding (274..668): X

NRPSPredictor2: phe, trp, phg, tyr, bht

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aromatic
Large clusters prediction:: phe, trp, phg, tyr, bht
Small clusters prediction:: N/A
Single AA prediction:: N/A

Stachelhaus prediction details:

Stachelhaus sequence:: gviilaaick
Nearest Stachelhaus code:: N, A
Stachelhaus code match:: 0% (weak)

AMP-binding (1355..1750): X

NRPSPredictor2: hydrophobic-aromatic

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aromatic
Large clusters prediction:: N/A
Small clusters prediction:: N/A
Single AA prediction:: N/A

Stachelhaus prediction details:

Stachelhaus sequence:: dgmhvvgvsk
Nearest Stachelhaus code:: N, A
Stachelhaus code match:: 0% (weak)

AMP-binding (2886..3283): ala

NRPSPredictor2: ala

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic
Large clusters prediction:: gly, ala, val, leu, ile, abu, iva
Small clusters prediction:: gly, ala
Single AA prediction:: ala

Stachelhaus prediction details:

Stachelhaus sequence:: divmsagalk
Nearest Stachelhaus code:: N, A
Stachelhaus code match:: 0% (weak)