BGC0000366 - 1 region(s) - antiSMASH results

Identified secondary metabolite regions using strictness 'relaxed'

BGC0000366 (Streptomyces sp. NRRL F-4415)

Region	Type	From	To	Most similar known cluster		Similarity
Region 1	NRPS	1	36,842	scabichelin	NRP	60%

BGC0000366 - Region 1 - NRPS

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Location: 1 - 36,842 nt. (total: 36,842 nt) Show pHMM detection rules used

Region on contig edge.

NRPS: cds(Condensation and (AMP-binding or A-OX))

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core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

TTA codons

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Gene details

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MIBiG

NRPS/PKS domains

MIBiG comparison

KnownClusterBlast

NRPS/PKS modules

External annotation

Name		MIBiG
Version		3.0

Type		Subregion
Location		1 - 36,843
Label		BGC0000366

Detailed domain annotation

Selected features only

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Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000366.1	0.83	NRP	gobichelin A, gobichelin B	Streptomyces sp. NRRL F-4415
BGC0000389.1	0.37	NRP	massetolide A	Pseudomonas fluorescens SS101
BGC0001615.1	0.34	NRP	hexose-palythine-serine, hexose-shinorine	Heteroscytonema crispum UCFS10
BGC0002075.1	0.32	NRP, Alkaloid	Pyreudione A, Pyreudione B, Pyreudione C, Pyreudione D, Pyreudione E	Pseudomonas fluorescens
BGC0000457.1	0.32	NRP	vicibactin	Rhizobium etli CFN 42
BGC0001833.1	0.32	NRP	icosalide A, icosalide B	Burkholderia gladioli
BGC0001132.1	0.31	NRP	xenotetrapeptide	Xenorhabdus nematophila ATCC 19061
BGC0001825.1	0.30	NRP	xenematide	Xenorhabdus nematophila AN6/1
BGC0000396.1	0.30	NRP	nodularin	Nostoc sp. 73.1
BGC0001128.1	0.29	NRP	luminmide	Photorhabdus laumondii subsp. laumondii TTO1

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000366.1	0.94	NRP	gobichelin A, gobichelin B	Streptomyces sp. NRRL F-4415
BGC0000389.1	0.70	NRP	massetolide A	Pseudomonas fluorescens SS101
BGC0001615.1	0.67	NRP	hexose-palythine-serine, hexose-shinorine	Heteroscytonema crispum UCFS10
BGC0002075.1	0.66	NRP, Alkaloid	Pyreudione A, Pyreudione B, Pyreudione C, Pyreudione D, Pyreudione E	Pseudomonas fluorescens
BGC0000457.1	0.65	NRP	vicibactin	Rhizobium etli CFN 42
BGC0001833.1	0.65	NRP	icosalide A, icosalide B	Burkholderia gladioli
BGC0001132.1	0.65	NRP	xenotetrapeptide	Xenorhabdus nematophila ATCC 19061
BGC0001825.1	0.64	NRP	xenematide	Xenorhabdus nematophila AN6/1
BGC0000396.1	0.63	NRP	nodularin	Nostoc sp. 73.1
BGC0001128.1	0.63	NRP	luminmide	Photorhabdus laumondii subsp. laumondii TTO1

Similar known gene clusters

Module view

Legend

NRPS/PKS products

NRPS/PKS monomers

Predicted core structure(s)

For candidate cluster 1, location 0 - 36842:

Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:: (cys) + (X - D-X) + (ser - X)

Direct lookup in NORINE database: strict or relaxed

Link to NORINE database query form

NRPS/PKS monomer predictions

gobJ

Search NORINE for peptide: strict or relaxed

AMP-binding (627..1019): cys

NRPSPredictor2: cys

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic
Large clusters prediction:: cys
Small clusters prediction:: cys
Single AA prediction:: cys

Stachelhaus prediction details:

Stachelhaus sequence:: DLFNLgLIhK
Nearest Stachelhaus code:: cys
Stachelhaus code match:: 80% (moderate)

gobK

Search NORINE for peptide: strict or relaxed

AMP-binding (73..475): sal

NRPSPredictor2: sal

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aromatic
Large clusters prediction:: dhb, sal
Small clusters prediction:: dhb, sal
Single AA prediction:: dhb

Stachelhaus prediction details:

Stachelhaus sequence:: PLPAQGVLNK
Nearest Stachelhaus code:: sal
Stachelhaus code match:: 100% (strong)

gobR

Search NORINE for peptide: strict or relaxed

AMP-binding (448..844): X

NRPSPredictor2: phe, trp

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aromatic
Large clusters prediction:: phe, trp, phg, tyr, bht
Small clusters prediction:: phe, trp
Single AA prediction:: N/A

Stachelhaus prediction details:

Stachelhaus sequence:: DtWTIAsVdK
Nearest Stachelhaus code:: phe
Stachelhaus code match:: 70% (weak)

AMP-binding (1505..1908): X

NRPSPredictor2: ser, thr, dhpg, hpg

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic
Large clusters prediction:: ser, thr, dhpg, hpg
Small clusters prediction:: N/A
Single AA prediction:: N/A

Stachelhaus prediction details:

Stachelhaus sequence:: DAlDgGfVDK
Nearest Stachelhaus code:: gln
Stachelhaus code match:: 70% (weak)

gobS

Search NORINE for peptide: strict or relaxed

AMP-binding (462..862): ser

NRPSPredictor2: ser

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic
Large clusters prediction:: ser, thr, dhpg, hpg
Small clusters prediction:: ser
Single AA prediction:: ser

Stachelhaus prediction details:

Stachelhaus sequence:: DVWHlSLVDK
Nearest Stachelhaus code:: ser
Stachelhaus code match:: 90% (moderate)

AMP-binding (1531..1939): X

NRPSPredictor2: (unknown)

SVM prediction details:

Predicted physicochemical class:: N/A
Large clusters prediction:: N/A
Small clusters prediction:: N/A
Single AA prediction:: N/A

Stachelhaus prediction details:

Stachelhaus sequence:: DAWeaGLvDK
Nearest Stachelhaus code:: gln
Stachelhaus code match:: 70% (weak)