BGC0000953 - 1 region(s) - antiSMASH results

Identified secondary metabolite regions using strictness 'relaxed'

BGC0000953 (Streptomyces vinaceusdrappus)

Region	Type	From	To	Most similar known cluster		Similarity
Region 1	NRPS-like	1	37,337

BGC0000953 - Region 1 - NRPS-like

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Location: 1 - 37,337 nt. (total: 37,337 nt) Show pHMM detection rules used

Region on contig edge.

NRPS-like: cds((PP-binding or NAD_binding_4) and (AMP-binding or A-OX))

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core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

TTA codons

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Gene details

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MIBiG

NRPS/PKS domains

MIBiG comparison

KnownClusterBlast

NRPS/PKS modules

External annotation

Name		MIBiG
Version		3.0

Type		Subregion
Location		1 - 37,338
Label		BGC0000953

Detailed domain annotation

Selected features only

Show module domains

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000953.1	0.98	Saccharide	amicetin	Streptomyces vinaceusdrappus
BGC0000375.1	0.34	NRP	indigoidine	Streptomyces chromofuscus
BGC0000427.1	0.34	NRP	shinorine, 4-deoxygadusol, mycosporine glycine	Trichormus variabilis ATCC 29413
BGC0000900.1	0.28	Other	ferrichrome	Aspergillus oryzae
BGC0001249.1	0.27	NRP	dimethylcoprogen	Alternaria alternata
BGC0000348.1	0.27	NRP	ergovaline	Epichloe festucae var. lolii
BGC0000979.1	0.26	NRP, Polyketide	cylindrospermopsin	Aphanizomenon sp. 10E9
BGC0000980.1	0.26	NRP, Polyketide	cylindrospermopsin	Aphanizomenon sp. 22D11
BGC0000876.1	0.25	Other	neopolyoxin C	Streptomyces tendae
BGC0000921.1	0.25	Other, Polyketide, NRP, , (, S, h, i, k, i, m, a, t, e, -, d, e, r, i, v, e, d, )	promysalin	Pseudomonas putida

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000953.1	1.00	Saccharide	amicetin	Streptomyces vinaceusdrappus
BGC0000375.1	0.67	NRP	indigoidine	Streptomyces chromofuscus
BGC0000427.1	0.67	NRP	shinorine, 4-deoxygadusol, mycosporine glycine	Trichormus variabilis ATCC 29413
BGC0000900.1	0.62	Other	ferrichrome	Aspergillus oryzae
BGC0001249.1	0.61	NRP	dimethylcoprogen	Alternaria alternata
BGC0000348.1	0.61	NRP	ergovaline	Epichloe festucae var. lolii
BGC0000979.1	0.60	NRP, Polyketide	cylindrospermopsin	Aphanizomenon sp. 10E9
BGC0000980.1	0.60	NRP, Polyketide	cylindrospermopsin	Aphanizomenon sp. 22D11
BGC0000876.1	0.59	Other	neopolyoxin C	Streptomyces tendae
BGC0000921.1	0.58	Other, Polyketide, NRP, , (, S, h, i, k, i, m, a, t, e, -, d, e, r, i, v, e, d, )	promysalin	Pseudomonas putida

Similar known gene clusters

No matches found.

Module view

Legend

NRPS/PKS products

NRPS/PKS monomers

Predicted core structure(s)

For candidate cluster 1, location 11328 - 37337:

Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:: (cys)

Direct lookup in NORINE database: strict or relaxed

Link to NORINE database query form

NRPS/PKS monomer predictions

amiL

Search NORINE for peptide: strict or relaxed

AMP-binding (16..392): X

NRPSPredictor2: (unknown)

SVM prediction details:

NOTE: outside applicability domain

Predicted physicochemical class:: hydrophobic-aliphatic
Large clusters prediction:: N/A
Small clusters prediction:: N/A
Single AA prediction:: N/A

Stachelhaus prediction details:

Stachelhaus sequence:: tynFVAqnaK
Nearest Stachelhaus code:: ala
Stachelhaus code match:: 40% (weak)

amiR

PKS_AT (81..238): pk

ATSignature: (unknown)

No matches above 50%

minowa: trans-1,2-CPDA

Prediction, score:

trans-1,2-CPDA: 0.0
inactive: 0.0
fatty_acid: 0.0
Propionyl-CoA: 0.0
Methylmalonyl-CoA: 0.0
Methoxymalonyl-CoA: 0.0
Malonyl-CoA: 0.0
Isobutyryl-CoA: 0.0
Ethylmalonyl-CoA: 0.0
CHC-CoA: 0.0
Benzoyl-CoA: 0.0
Acetyl-CoA: 0.0
3-Methylbutyryl-CoA: 0.0
2-Methylbutyryl-CoA: 0.0

amiT

Search NORINE for peptide: strict or relaxed

AMP-binding (233..638): cys

NRPSPredictor2: cys

SVM prediction details:

Predicted physicochemical class:: hydrophilic
Large clusters prediction:: cys
Small clusters prediction:: cys
Single AA prediction:: cys

Stachelhaus prediction details:

Stachelhaus sequence:: DMyNmGLIhK
Nearest Stachelhaus code:: orn
Stachelhaus code match:: 70% (weak)