BGC0000979 - 1 region(s) - antiSMASH results

Identified secondary metabolite regions using strictness 'relaxed'

BGC0000979 (Aphanizomenon sp. 10E9)

Region	Type	From	To	Most similar known cluster		Similarity
Region 1	NRPS-like,T1PKS	1	6,921	cylindrospermopsin	NRP + Polyketide	100%

BGC0000979 - Region 1 - NRPS-like,T1PKS

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Location: 1 - 6,921 nt. (total: 6,921 nt) Show pHMM detection rules used

Region on contig edge.

NRPS-like: cds((PP-binding or NAD_binding_4) and (AMP-binding or A-OX))
T1PKS: cds(PKS_AT and (PKS_KS or ene_KS or mod_KS or hyb_KS or itr_KS or tra_KS))

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core biosynthetic genes

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Gene details

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MIBiG

NRPS/PKS domains

MIBiG comparison

KnownClusterBlast

NRPS/PKS modules

External annotation

Name		MIBiG
Version		3.0

Type		Subregion
Location		1 - 6,922
Label		BGC0000979

Detailed domain annotation

Selected features only

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Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000979.1	2.00	NRP, Polyketide	cylindrospermopsin	Aphanizomenon sp. 10E9
BGC0000980.1	2.00	NRP, Polyketide	cylindrospermopsin	Aphanizomenon sp. 22D11
BGC0000427.1	0.71	NRP	shinorine, 4-deoxygadusol, mycosporine glycine	Trichormus variabilis ATCC 29413
BGC0000375.1	0.58	NRP	indigoidine	Streptomyces chromofuscus
BGC0000981.1	0.56	NRP, Polyketide	cylindrospermopsin	Aphanizomenon sp. 10E6
BGC0000900.1	0.54	Other	ferrichrome	Aspergillus oryzae
BGC0001068.1	0.51	Terpene, Polyketide	pyripyropene A	unidentified unclassified sequences.
BGC0001479.1	0.50	NRP	anabaenopeptin NZ857, nostamide A	Nostoc punctiforme PCC 73102
BGC0001794.1	0.47	Polyketide	swainsonine	Alternaria oxytropis
BGC0000056.1	0.47	Polyketide	esperamicin	Actinomadura verrucosospora

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000979.1	1.00	NRP, Polyketide	cylindrospermopsin	Aphanizomenon sp. 10E9
BGC0000980.1	1.00	NRP, Polyketide	cylindrospermopsin	Aphanizomenon sp. 22D11
BGC0000427.1	0.68	NRP	shinorine, 4-deoxygadusol, mycosporine glycine	Trichormus variabilis ATCC 29413
BGC0000375.1	0.62	NRP	indigoidine	Streptomyces chromofuscus
BGC0000981.1	0.62	NRP, Polyketide	cylindrospermopsin	Aphanizomenon sp. 10E6
BGC0000900.1	0.61	Other	ferrichrome	Aspergillus oryzae
BGC0001068.1	0.59	Terpene, Polyketide	pyripyropene A	unidentified unclassified sequences.
BGC0001479.1	0.58	NRP	anabaenopeptin NZ857, nostamide A	Nostoc punctiforme PCC 73102
BGC0001794.1	0.57	Polyketide	swainsonine	Alternaria oxytropis
BGC0000056.1	0.57	Polyketide	esperamicin	Actinomadura verrucosospora

Similar known gene clusters

Module view

Legend

NRPS/PKS products

NRPS/PKS monomers

Predicted core structure(s)

For candidate cluster 1, location 0 - 6921:

Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:: (X)

Direct lookup in NORINE database: strict or relaxed

Link to NORINE database query form

NRPS/PKS monomer predictions

cyrB

Search NORINE for peptide: strict or relaxed

AMP-binding (28..469): X

NRPSPredictor2: (unknown)

SVM prediction details:

NOTE: outside applicability domain

Predicted physicochemical class:: hydrophobic-aliphatic
Large clusters prediction:: pro, pip
Small clusters prediction:: val, leu, ile, abu, iva
Single AA prediction:: N/A

Stachelhaus prediction details:

Stachelhaus sequence:: DfhFItHdAK
Nearest Stachelhaus code:: pro
Stachelhaus code match:: 60% (weak)

PKS_AT (1210..1393): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 66.7%; inactive: 62.5%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 116.4
inactive: 96.7
Methoxymalonyl-CoA: 39.4
Methylmalonyl-CoA: 36.6
Propionyl-CoA: 22.5
Benzoyl-CoA: 20.8
Acetyl-CoA: 17.9
Isobutyryl-CoA: 17.2
Ethylmalonyl-CoA: 11.8
trans-1,2-CPDA: 11.6
2-Methylbutyryl-CoA: 11.5
fatty_acid: 0.0
CHC-CoA: 0.0
3-Methylbutyryl-CoA: 0.0