BGC0001492 - 1 region(s) - antiSMASH results

Identified secondary metabolite regions using strictness 'relaxed'

BGC0001492 (Streptomyces sp. LC-6-2)

Region	Type	From	To	Most similar known cluster		Similarity
Region 1	T1PKS	1	70,308	abyssomicin C / atrop-abyssomicin C	Polyketide:Modular type I	46%

BGC0001492 - Region 1 - T1PKS

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Location: 1 - 70,308 nt. (total: 70,308 nt) Show pHMM detection rules used

Region on contig edge.

T1PKS: cds(PKS_AT and (PKS_KS or ene_KS or mod_KS or hyb_KS or itr_KS or tra_KS))

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core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

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TTA codons

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Gene details

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MIBiG

NRPS/PKS domains

MIBiG comparison

KnownClusterBlast

NRPS/PKS modules

External annotation

Name		MIBiG
Version		3.0

Type		Subregion
Location		1 - 70,309
Label		BGC0001492

Detailed domain annotation

Selected features only

Show module domains

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001492.1	0.89	Polyketide	abyssomicin M, abyssomicin N, abyssomicin O, abyssomicin P, abyssomicin Q, abyssomicin R, abyssomicin S, abyssomicin T, abyssomicin U, abyssomicin V, abyssomicin W, abyssomicin X	Streptomyces sp. LC-6-2
BGC0000041.1	0.35	Polyketide	oronofacic acid	Pseudomonas syringae
BGC0001273.1	0.33	Polyketide	asperlactone	Aspergillus ochraceus
BGC0001276.1	0.33	Polyketide	6-methylsalicyclic acid	Aspergillus terreus
BGC0001275.1	0.32	Polyketide	6-methylsalicyclic acid	Glarea lozoyensis
BGC0000170.1	0.31	Polyketide	yanuthone D	Aspergillus niger ATCC 1015
BGC0000122.1	0.31	Polyketide	phenylnannolone A, phenylnannolone B, phenylnannolone C	Nannocystis pusilla
BGC0000160.1	0.31	Polyketide	terreic acid	Aspergillus terreus NIH2624
BGC0001854.1	0.31	Polyketide	tricholignan A	Trichoderma harzianum
BGC0001901.1	0.31	Polyketide	tricholignan A	Trichoderma harzianum

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001492.1	0.97	Polyketide	abyssomicin M, abyssomicin N, abyssomicin O, abyssomicin P, abyssomicin Q, abyssomicin R, abyssomicin S, abyssomicin T, abyssomicin U, abyssomicin V, abyssomicin W, abyssomicin X	Streptomyces sp. LC-6-2
BGC0000041.1	0.68	Polyketide	oronofacic acid	Pseudomonas syringae
BGC0001273.1	0.66	Polyketide	asperlactone	Aspergillus ochraceus
BGC0001276.1	0.66	Polyketide	6-methylsalicyclic acid	Aspergillus terreus
BGC0001275.1	0.65	Polyketide	6-methylsalicyclic acid	Glarea lozoyensis
BGC0000170.1	0.65	Polyketide	yanuthone D	Aspergillus niger ATCC 1015
BGC0000122.1	0.65	Polyketide	phenylnannolone A, phenylnannolone B, phenylnannolone C	Nannocystis pusilla
BGC0000160.1	0.64	Polyketide	terreic acid	Aspergillus terreus NIH2624
BGC0001854.1	0.64	Polyketide	tricholignan A	Trichoderma harzianum
BGC0001901.1	0.64	Polyketide	tricholignan A	Trichoderma harzianum

Similar known gene clusters

Module view

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NRPS/PKS products

NRPS/PKS monomers

Predicted core structure(s)

For candidate cluster 1, location 0 - 69464:

Rough prediction of core scaffold based on assumed PKS linker matching; tailoring reactions not taken into account

Polymer prediction:: (mal - Me-ccmal - ccmal - ccmal) + (Me-mal - Me-redmal) + (mal)
Non-colinear ordering:: ARE67853.1 + ARE67852.1 + ARE67851.1

Direct lookup in NORINE database: strict or relaxed

Link to NORINE database query form

NRPS/PKS monomer predictions

ARE67853.1

PKS_AT (547..840): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 95.8%; inactive: 83.3%; Methylmalonyl-CoA: 58.3%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 186.5
inactive: 94.0
Methoxymalonyl-CoA: 76.9
Methylmalonyl-CoA: 70.0
Isobutyryl-CoA: 42.5
Propionyl-CoA: 39.4
Ethylmalonyl-CoA: 38.8
2-Methylbutyryl-CoA: 25.2
Acetyl-CoA: 21.9
CHC-CoA: 19.7
fatty_acid: 16.1
Benzoyl-CoA: 15.9
trans-1,2-CPDA: 13.2
3-Methylbutyryl-CoA: 3.4

PKS_AT (1568..1859): mmal

ATSignature: Methylmalonyl-CoA

Top 3 matches:: Methylmalonyl-CoA: 100.0%; Methoxymalonyl-CoA: 91.7%; Ethylmalonyl-CoA: 87.5%

minowa: Methylmalonyl-CoA

Prediction, score:

Methylmalonyl-CoA: 210.0
Ethylmalonyl-CoA: 208.9
Methoxymalonyl-CoA: 175.7
2-Methylbutyryl-CoA: 142.1
trans-1,2-CPDA: 139.3
Propionyl-CoA: 109.6
CHC-CoA: 97.0
Malonyl-CoA: 85.4
Isobutyryl-CoA: 84.1
Benzoyl-CoA: 68.8
Acetyl-CoA: 45.6
3-Methylbutyryl-CoA: 44.7
inactive: 24.4
fatty_acid: 23.2

PKS_AT (3377..3660): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 87.5%; inactive: 75.0%; Methylmalonyl-CoA: 54.2%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 193.0
inactive: 75.6
Methoxymalonyl-CoA: 62.7
Methylmalonyl-CoA: 61.9
Isobutyryl-CoA: 32.1
Propionyl-CoA: 31.7
Ethylmalonyl-CoA: 31.5
trans-1,2-CPDA: 17.4
Acetyl-CoA: 17.2
Benzoyl-CoA: 16.0
2-Methylbutyryl-CoA: 9.8
fatty_acid: 8.5
3-Methylbutyryl-CoA: 6.1
CHC-CoA: 0.8

PKS_AT (5104..5396): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 87.5%; inactive: 75.0%; Propionyl-CoA: 54.2%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 164.2
Methoxymalonyl-CoA: 63.3
inactive: 62.5
Methylmalonyl-CoA: 58.9
Ethylmalonyl-CoA: 33.2
Propionyl-CoA: 22.7
Isobutyryl-CoA: 18.7
CHC-CoA: 15.0
Acetyl-CoA: 14.5
fatty_acid: 13.8
trans-1,2-CPDA: 11.8
3-Methylbutyryl-CoA: 11.8
Benzoyl-CoA: 11.7
2-Methylbutyryl-CoA: 10.7

ARE67852.1

PKS_AT (636..936): mmal

ATSignature: Methylmalonyl-CoA

Top 3 matches:: Methylmalonyl-CoA: 95.8%; Methoxymalonyl-CoA: 91.7%; Malonyl-CoA: 87.5%

minowa: Methylmalonyl-CoA

Prediction, score:

Methylmalonyl-CoA: 194.5
Ethylmalonyl-CoA: 189.7
Methoxymalonyl-CoA: 159.8
2-Methylbutyryl-CoA: 136.3
trans-1,2-CPDA: 126.9
Propionyl-CoA: 108.4
CHC-CoA: 99.9
Malonyl-CoA: 85.0
Isobutyryl-CoA: 75.1
Benzoyl-CoA: 57.2
3-Methylbutyryl-CoA: 47.3
Acetyl-CoA: 44.2
fatty_acid: 34.3
inactive: 13.7

PKS_AT (1965..2275): mmal

ATSignature: Methylmalonyl-CoA

Top 3 matches:: Methylmalonyl-CoA: 100.0%; Methoxymalonyl-CoA: 91.7%; Malonyl-CoA: 87.5%

minowa: Methylmalonyl-CoA

Prediction, score:

Methylmalonyl-CoA: 191.7
Ethylmalonyl-CoA: 171.8
Methoxymalonyl-CoA: 169.8
trans-1,2-CPDA: 117.1
2-Methylbutyryl-CoA: 113.5
Malonyl-CoA: 102.9
Propionyl-CoA: 95.8
CHC-CoA: 74.9
Isobutyryl-CoA: 67.5
Benzoyl-CoA: 47.4
3-Methylbutyryl-CoA: 41.5
Acetyl-CoA: 39.7
inactive: 25.9
fatty_acid: 18.2

ARE67851.1

PKS_AT (570..874): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 87.5%; inactive: 70.8%; Propionyl-CoA: 62.5%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 158.6
inactive: 69.8
Methoxymalonyl-CoA: 67.3
Methylmalonyl-CoA: 57.6
Propionyl-CoA: 56.8
Ethylmalonyl-CoA: 34.5
2-Methylbutyryl-CoA: 32.4
CHC-CoA: 29.7
trans-1,2-CPDA: 15.0
Acetyl-CoA: 13.5
fatty_acid: 11.0
Isobutyryl-CoA: 9.9
Benzoyl-CoA: 0.0
3-Methylbutyryl-CoA: 0.0