BGC0001648 - 1 region(s) - antiSMASH results

Identified secondary metabolite regions using strictness 'relaxed'

BGC0001648 (Streptomyces sp)

Region	Type	From	To	Most similar known cluster		Similarity
Region 1	T1PKS	1	76,167	lasalocid	Polyketide	28%

BGC0001648 - Region 1 - T1PKS

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Location: 1 - 76,167 nt. (total: 76,167 nt) Show pHMM detection rules used

Region on contig edge.

T1PKS: cds(PKS_AT and (PKS_KS or ene_KS or mod_KS or hyb_KS or itr_KS or tra_KS))

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core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

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TTA codons

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Gene details

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MIBiG

NRPS/PKS domains

MIBiG comparison

KnownClusterBlast

NRPS/PKS modules

External annotation

Name		MIBiG
Version		3.0

Type		Subregion
Location		1 - 76,168
Label		BGC0001648

Detailed domain annotation

Selected features only

Show module domains

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001648.1	0.70	Polyketide	lasalocid	Streptomyces sp.
BGC0000086.1	0.32	Polyketide	lasalocid	Streptomyces lasaliensis
BGC0000041.1	0.30	Polyketide	oronofacic acid	Pseudomonas syringae
BGC0000030.1	0.28	Polyketide	bikaverin	Fusarium fujikuroi IMI 58289
BGC0000087.1	0.27	Polyketide	lasalocid	Streptomyces lasaliensis
BGC0000046.1	0.27	Polyketide	depudecin	Alternaria brassicicola
BGC0001903.1	0.26	Other	neocarazostatin A	Streptomyces sp. MA37
BGC0000019.1	0.26	Polyketide	angolamycin	Streptomyces eurythermus
BGC0000286.1	0.25	Polyketide	viguiepinol	Streptomyces sp. KO-3988
BGC0001858.1	0.25	Polyketide	alternapyrone B, alternapyrone C, alternapyrone D, alternapyrone E, alternapyrone F	Parastagonospora nodorum SN15

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001648.1	0.89	Polyketide	lasalocid	Streptomyces sp.
BGC0000086.1	0.65	Polyketide	lasalocid	Streptomyces lasaliensis
BGC0000041.1	0.63	Polyketide	oronofacic acid	Pseudomonas syringae
BGC0000030.1	0.62	Polyketide	bikaverin	Fusarium fujikuroi IMI 58289
BGC0000087.1	0.61	Polyketide	lasalocid	Streptomyces lasaliensis
BGC0000046.1	0.61	Polyketide	depudecin	Alternaria brassicicola
BGC0001903.1	0.60	Other	neocarazostatin A	Streptomyces sp. MA37
BGC0000019.1	0.59	Polyketide	angolamycin	Streptomyces eurythermus
BGC0000286.1	0.59	Polyketide	viguiepinol	Streptomyces sp. KO-3988
BGC0001858.1	0.59	Polyketide	alternapyrone B, alternapyrone C, alternapyrone D, alternapyrone E, alternapyrone F	Parastagonospora nodorum SN15

Similar known gene clusters

Module view

Legend

NRPS/PKS products

NRPS/PKS monomers

Predicted core structure(s)

For candidate cluster 1, location 0 - 76167:

Rough prediction of core scaffold based on assumed PKS linker matching; tailoring reactions not taken into account

Polymer prediction:: (mal) + (Me-ohmal) + (redmal - pk) + (redmal) + (pk - Me-redmal - ohmal) + (Me-ccmal) + (Me-mal) + (mal)
Non-colinear ordering:: ANR02549.1 + ANR02552.1 + ANR02553.1 + ANR02554.1 + ANR02555.1 + ANR02556.1 + ANR02551.1 + ANR02557.1

Direct lookup in NORINE database: strict or relaxed

Link to NORINE database query form

NRPS/PKS monomer predictions

ANR02549.1

PKS_AT (540..839): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 95.8%; inactive: 83.3%; 2-Rhyd-Malonyl-CoA: 58.3%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 227.3
inactive: 110.0
Methoxymalonyl-CoA: 83.0
Methylmalonyl-CoA: 63.9
Propionyl-CoA: 52.8
Isobutyryl-CoA: 43.2
Ethylmalonyl-CoA: 28.2
Acetyl-CoA: 25.8
2-Methylbutyryl-CoA: 24.0
fatty_acid: 21.4
Benzoyl-CoA: 20.4
CHC-CoA: 18.4
3-Methylbutyryl-CoA: 8.7
trans-1,2-CPDA: 5.4

ANR02551.1

PKS_AT (564..861): mmal

ATSignature: Methylmalonyl-CoA

Top 3 matches:: Methylmalonyl-CoA: 100.0%; Methoxymalonyl-CoA: 95.8%; Ethylmalonyl-CoA: 91.7%

minowa: Methylmalonyl-CoA

Prediction, score:

Methylmalonyl-CoA: 194.6
Ethylmalonyl-CoA: 179.2
Methoxymalonyl-CoA: 157.0
2-Methylbutyryl-CoA: 145.0
trans-1,2-CPDA: 120.6
Propionyl-CoA: 101.1
CHC-CoA: 94.3
Malonyl-CoA: 74.6
Isobutyryl-CoA: 63.4
Benzoyl-CoA: 53.0
Acetyl-CoA: 32.3
fatty_acid: 28.0
3-Methylbutyryl-CoA: 27.0
inactive: 14.0

ANR02552.1

PKS_AT (569..866): mmal

ATSignature: Methylmalonyl-CoA

Top 3 matches:: Methylmalonyl-CoA: 100.0%; Methoxymalonyl-CoA: 95.8%; Ethylmalonyl-CoA: 91.7%

minowa: Methylmalonyl-CoA

Prediction, score:

Methylmalonyl-CoA: 192.8
Ethylmalonyl-CoA: 177.1
Methoxymalonyl-CoA: 157.0
2-Methylbutyryl-CoA: 144.0
trans-1,2-CPDA: 112.5
CHC-CoA: 100.9
Propionyl-CoA: 100.4
Malonyl-CoA: 73.2
Isobutyryl-CoA: 63.9
Benzoyl-CoA: 50.9
Acetyl-CoA: 26.7
3-Methylbutyryl-CoA: 25.3
fatty_acid: 20.3
inactive: 12.8

ANR02553.1

PKS_AT (563..849): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 100.0%; inactive: 83.3%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 172.5
inactive: 83.8
Methoxymalonyl-CoA: 41.3
Methylmalonyl-CoA: 27.9
Propionyl-CoA: 26.6
Acetyl-CoA: 16.0
fatty_acid: 15.7
Isobutyryl-CoA: 13.3
Benzoyl-CoA: 11.7
2-Methylbutyryl-CoA: 9.7
trans-1,2-CPDA: 1.6
Ethylmalonyl-CoA: 0.0
CHC-CoA: 0.0
3-Methylbutyryl-CoA: 0.0

PKS_AT (2623..2916): pk

ATSignature: Ethylmalonyl-CoA

Top 3 matches:: Ethylmalonyl-CoA: 100.0%; Methoxymalonyl-CoA: 87.5%; Methylmalonyl-CoA: 79.2%

minowa: Methylmalonyl-CoA

Prediction, score:

Methylmalonyl-CoA: 183.3
Ethylmalonyl-CoA: 173.9
Methoxymalonyl-CoA: 145.9
2-Methylbutyryl-CoA: 118.6
trans-1,2-CPDA: 104.9
CHC-CoA: 94.6
Propionyl-CoA: 91.6
Malonyl-CoA: 77.2
Isobutyryl-CoA: 57.2
Benzoyl-CoA: 37.7
fatty_acid: 33.4
3-Methylbutyryl-CoA: 21.7
inactive: 20.2
Acetyl-CoA: 17.6

ANR02554.1

PKS_AT (1312..1600): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 100.0%; inactive: 83.3%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 177.1
inactive: 94.4
Methoxymalonyl-CoA: 41.9
Methylmalonyl-CoA: 30.3
Propionyl-CoA: 29.6
fatty_acid: 16.1
Isobutyryl-CoA: 15.8
Acetyl-CoA: 15.8
Benzoyl-CoA: 12.0
CHC-CoA: 8.3
Ethylmalonyl-CoA: 7.4
2-Methylbutyryl-CoA: 6.5
trans-1,2-CPDA: 1.1
3-Methylbutyryl-CoA: 0.0

ANR02555.1

PKS_AT (566..859): pk

ATSignature: Ethylmalonyl-CoA

Top 3 matches:: Ethylmalonyl-CoA: 100.0%; Methoxymalonyl-CoA: 87.5%; Methylmalonyl-CoA: 79.2%

minowa: Methylmalonyl-CoA

Prediction, score:

Methylmalonyl-CoA: 184.8
Ethylmalonyl-CoA: 175.9
Methoxymalonyl-CoA: 147.3
2-Methylbutyryl-CoA: 120.2
trans-1,2-CPDA: 104.7
CHC-CoA: 95.8
Propionyl-CoA: 91.1
Malonyl-CoA: 80.4
Isobutyryl-CoA: 59.5
Benzoyl-CoA: 39.5
fatty_acid: 33.8
3-Methylbutyryl-CoA: 22.7
inactive: 20.0
Acetyl-CoA: 19.6

PKS_AT (2329..2626): mmal

ATSignature: Methylmalonyl-CoA

Top 3 matches:: Methylmalonyl-CoA: 100.0%; Methoxymalonyl-CoA: 95.8%; Ethylmalonyl-CoA: 91.7%

minowa: Methylmalonyl-CoA

Prediction, score:

Methylmalonyl-CoA: 193.5
Ethylmalonyl-CoA: 177.4
Methoxymalonyl-CoA: 157.8
2-Methylbutyryl-CoA: 144.8
trans-1,2-CPDA: 114.2
CHC-CoA: 101.8
Propionyl-CoA: 101.0
Malonyl-CoA: 73.5
Isobutyryl-CoA: 64.2
Benzoyl-CoA: 51.4
Acetyl-CoA: 26.4
3-Methylbutyryl-CoA: 26.2
fatty_acid: 21.0
inactive: 12.9

PKS_AT (4392..4680): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 100.0%; inactive: 83.3%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 175.6
inactive: 85.8
Methoxymalonyl-CoA: 40.0
Methylmalonyl-CoA: 29.0
Propionyl-CoA: 22.9
fatty_acid: 17.5
Acetyl-CoA: 16.0
Isobutyryl-CoA: 15.4
Benzoyl-CoA: 11.6
2-Methylbutyryl-CoA: 10.0
trans-1,2-CPDA: 1.3
Ethylmalonyl-CoA: 0.0
CHC-CoA: 0.0
3-Methylbutyryl-CoA: 0.0

ANR02556.1

PKS_AT (601..898): mmal

ATSignature: Methylmalonyl-CoA

Top 3 matches:: Methylmalonyl-CoA: 100.0%; Methoxymalonyl-CoA: 95.8%; Ethylmalonyl-CoA: 91.7%

minowa: Methylmalonyl-CoA

Prediction, score:

Methylmalonyl-CoA: 192.8
Ethylmalonyl-CoA: 177.1
Methoxymalonyl-CoA: 157.0
2-Methylbutyryl-CoA: 144.0
trans-1,2-CPDA: 112.5
CHC-CoA: 100.9
Propionyl-CoA: 100.4
Malonyl-CoA: 73.2
Isobutyryl-CoA: 63.9
Benzoyl-CoA: 50.9
Acetyl-CoA: 26.7
3-Methylbutyryl-CoA: 25.3
fatty_acid: 20.3
inactive: 12.8

ANR02557.1

PKS_AT (566..854): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 100.0%; inactive: 83.3%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 175.5
inactive: 94.6
Methoxymalonyl-CoA: 40.1
Methylmalonyl-CoA: 29.3
Propionyl-CoA: 26.4
Isobutyryl-CoA: 16.2
fatty_acid: 16.0
Acetyl-CoA: 15.8
Benzoyl-CoA: 12.0
2-Methylbutyryl-CoA: 8.4
CHC-CoA: 8.3
Ethylmalonyl-CoA: 7.4
trans-1,2-CPDA: 1.1
3-Methylbutyryl-CoA: 0.0